Conserved Protein Domain Family
Cyt_b561_CYBRD1

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cd08765: Cyt_b561_CYBRD1 
Vertebrate cytochrome b(561), CYBRD1 gene product
Duodenal cytochrome b or ferric-chelate reductase 3, a cytochrome b(561), as found in vertebrates, which might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. This protein is expressed at the brush border of duodenal enterocytes and may play a role in the uptake of dietary Fe(3+), facilitating its transport into the mucosal cells. It may also be involved in the recycling of extracellular ascorbate in erythrocyte membranes, and act as a ferrireductase in epithelial cells of the respiratory system. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.
Statistics
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PSSM-Id: 176495
View PSSM: cd08765
Aligned: 3 rows
Threshold Bit Score: 260.984
Threshold Setting Gi: 82192838
Created: 29-Apr-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative heme
Feature 1:putative heme binding sites [chemical binding site]
Evidence:
  • Comment:four conserved histidines may be involved in heme coordination

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                   #                                   #                             
Q53TN4     36 EGLGWDGSALEFNWHPVLMVTGFVFIQGIAIIVYRLPWTWkCSKLLMKSIHAGLNAVAAILAIISVVAVFenHNVNNIAN 115 human
Q503V1     34 EGLGWDGGAAEFNWHPLLMVIGFIFLQGIAIVVYRLPWTWrCSKQMMKLIHAGLHILAFILAVISVVAVFvfHNAKNIPN 113 zebrafish
Q6DDR3     34 EGLGWDGGAAEFNWHPVLVTSGFIFIQGIAIIVYRLPWTWkCSKLLMKFIHAGLHLTALIFTIVALVAVFdfHNAKNIPN 113 African clawed frog
Feature 1         #                                      #                             
Q53TN4    116 MYSLHSWVGLIAVICYLLQLLSGFSVFLLPWAPlsLRAFLMPIHVYSGIVIFGTVIATALMGLTEKLIFSLRD 188 human
Q503V1    114 MYSLHSWVGLAAVVLYPSQIVLGIAVYLIPVTPvrVRAALMPLHIYSGLFIFISVIAAALMGITEKLIFSLKS 186 zebrafish
Q6DDR3    114 MYSLHSWIGLTVVILYALQLVLGVSIYLLPFASntLRAALMPVHVYSGLFIFGTVIATALMGITEKLIFSLKE 186 African clawed frog

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