Conserved Protein Domain Family
Cyt_b561_CYBASC3

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cd08762: Cyt_b561_CYBASC3 
Vertebrate cytochrome b(561), CYBASC3 gene product
Cytochrome b ascorbate-dependent 3, as found in vertebrates, which might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.
Statistics
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PSSM-Id: 176492
View PSSM: cd08762
Aligned: 3 rows
Threshold Bit Score: 281.756
Threshold Setting Gi: 74730147
Created: 30-Mar-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative hemeputativeputative
Feature 1:putative heme binding sites [chemical binding site]
Evidence:
  • Comment:four conserved histidines may be involved in heme coordination

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                          #                                   #      
Q8NBI2     10 CLLLGSLGSMCILFTiyWMQYWRGGFAWNGSiYMFNWHPVLMVAGMVVFYGGASLVYRLPQSWvgPKLPWKLLHAALHLM 89  human
ACH43647   31 CAFLGTLGLLCVAMVgsWCQHWRGGFSLDGSsRTFNWHPVLMVTGLVVLYGAAALVYRIPYTWsgPKLPWKVLHGSLALG 110 zebra finch
A3KPR5     11 YLLCLILGIACVVLVvhWNFMYRDGFAWDGSsKNFNWHPVLMVTGMLVLYGNAAVVYRIPLTWghNKLPWKLLHAGLLLL 90  zebrafish
Feature 1                                #                                      #             
Q8NBI2     90 AFVLTVVGLVAVFTFHNhgRTANLYSLHSWLGITTVFLFACQWFLGFAVFLLPWAsmwLRSLLKPIHVFFGAAILSLSIA 169 human
ACH43647  111 AFILTVLGLLAVFYFHNsqGTPNMYSLHSWMGLGTVLLFSCQWAAGFGAFLLPWAptwLRVLYKPIHVFFGSTILLLSVA 190 zebra finch
A3KPR5     91 SFIFSVIGLCAVFNFHNvhHTANLYSLHSWVGICTAALFTAQWVMGFTSFLLPCTpmaVRAFVKPTHVWMGAMILVLSIV 170 zebrafish
Feature 1                        
Q8NBI2    170 SVISGINEKLFFSLKNTTR 188 human
ACH43647  191 SCVSGINEKLFFSLKNGTM 209 zebra finch
A3KPR5    171 SCISGINEKLFFVLKETTN 189 zebrafish

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