Conserved Protein Domain Family
Cyt_b561_CYB561D2_like

?
cd08761: Cyt_b561_CYB561D2_like 
Eukaryotic cytochrome b(561), including the CYB561D2 gene product
Cytochrome b(561), as found in eukaryotes, similar to and including the human CYB561D2 gene product. CYB561D2 is a candidate tumor suppressor. The protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.
Statistics
?
PSSM-Id: 176491
View PSSM: cd08761
Aligned: 48 rows
Threshold Bit Score: 99.2861
Threshold Setting Gi: 158271380
Created: 30-Mar-2010
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
 
putative heme
Feature 1:putative heme binding sites [chemical binding site]
Evidence:
  • Comment:four conserved histidines may be involved in heme coordination

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                        #                                       #        
O14569         25 LVALGFTIFVavlar--------pgssLFSWHPVLMSLAFSFLMTEALLv--FSPESSLlhslSRKGRARCHWVLQL-LA 93   human
XP_505818      49 LYGVLTTPII-----------------LFSYHPIFNSLGFFLLGQGILIt-qPEPRSAA----QKQVGGELHGILNS-LS 105  Yarrowia lipo...
XP_001730803   18 LAQVAVSSFVlcvigtgiykvwdgsfsFFAWHPILVTLGLFCLIQSILV---VQPTKTPa---EKQAGLNWHKTIVLyLG 91   Malassezia gl...
EAT89407       55 LAAIVWGAIFskk------------liFFSAHPLLNSAGFLLSIQAALI---LQPTHTPs---QKRTGTLVHFLLHV-LG 115  Phaeosphaeria...
EAK84298      880 VSALLFVVVVwsivfst---msilslpLFGYHPLIQSFTILLLLQAIVV---LQRTTPSqp-aAKKSAFTAHQWINLiLV 952  Ustilago mayd...
EDJ98420       42 LVGVVMFCFEvwystl-----sqkflpLFTPHPLLQSAAVAIALIGVLV---LQPTTSAdt-eRKRQGARLHVGIMG-LA 111  Magnaporthe g...
EDR11337       60 LVILTWVIVLsndp---------taqgWFALHPLLQTLAISLFTYGILT---LQPTSQLk---TKAAGLYRHQAAILlFG 124  Laccaria bico...
EDO97200        6 LLSLIYAGTVlhqvlvv---sklpldgLYTWHPICTNLFIIFASLGIWSaqsIRGKAALsr-sAKEPYVTRHGIFNW-LA 80   Chlamydomonas...
ACI65377       24 LISLISFSIGggy-----------lagTRPNGEWRLFSWHPMLMTSGMVg--LAGIGALtkklGGYTNTKLHALLGW-SS 89   Phaeodactylum...
EED92653       12 LTTILLAHSLiggy---------yagtRPEGAGWRYFSWHPLLMMCGMVg--LMGTAALtkkkGGYTNTKLHGIMAW-IG 79   Thalassiosira...
Feature 1                                   #                                         #           
O14569         94 LLCALLGLGLVILHKeqlGKAHLVTRHGQAGLLAVLWAGLQCSGGVGLLYPKLLpr---wPLAKLKLYHATSGLVGYLLG 170  human
XP_505818     106 VLAYCVGAGVILYNKeknHAEHFYSWHGTFGIITYGALVLVMLVGAAQFWWPIEvfgsvhKGRAIYKFHRVGGYLVWGLT 185  Yarrowia lipo...
XP_001730803   92 LPLITLGAWVVWYLHdlpGQKHFISWHGMLGCAIIVLIWTQAAFGATTVYWKSYfygtesRAKAMWKYHRMFGYTLCSLL 171  Malassezia gl...
EAT89407      116 ASALTAGLIVIEMNKagpGHEHFESPHARLGLAFYVLIYIQALVGFTQYYVPQLygg-vdNAKAIYKYHRVAGYVIAILG 194  Phaeosphaeria...
EAK84298      953 LPLFTAGASIMWYLHdqpASAHFISYHGILGTAVVIAAWVQAAFGAASVWWKGKlvggenKGKALWKWHRLSGYVLIALF 1032 Ustilago mayd...
EDJ98420      112 GLTFMAGVAIIEANKikgNNPHFKSLHAYLGVATAIIIACQATFGVLMWAVPGAfgg-vdNAKATWKYHRWFAYVVVLPM 190  Magnaporthe g...
EDR11337      125 LPSILLGTLAVSYNKwlrGARHFSTWHGTLGIFCIIWLVAQVGLGAGSVWFGGAvfgggvRAKAVWKYHRLSGYILFPLL 204  Laccaria bico...
EDO97200       81 LFSLVGAGATIYLNKeraGRPHLATYHGVAGASVAGFFVMNVFGGGAMNTVPSLy-----KYIKFHRLNGYILFLALLGA 155  Chlamydomonas...
ACI65377       90 IFTSFAGIYVIYRNKemnGYGHLKTAHSQAGAAVVVTTVGLGLAGSIFLHPDFGvd---kTNKTIRLAHKMASRITLMIA 166  Phaeodactylum...
EED92653       80 MMLSGGGLYVIYQNKvemGKDHFTTLHSWAGLAVLIGCTLAGLAGGIFLHPDFGid---kQNKTIRKVHKLLSRGLLIVA 156  Thalassiosira...
Feature 1                                                        
O14569        171 SASLLLGMcs----lwFTASVt--------GAAWYLAVLCPVLTSLV 205  human
XP_505818     186 AFTILLALes-----dFNHNA---------LHISYYTVAPGLALVAL 218  Yarrowia lipolytica CLIB122
XP_001730803  172 MAELLLAFwev--kwmYRTGGf--------VLVVLSTVTMLLTAYGV 208  Malassezia globosa CBS 7966
EAT89407      195 LATICASSwt-----tYSLNVa-------hIQHWAVIVASVLVLAGV 229  Phaeosphaeria nodorum SN15
EAK84298     1033 LLTAVLGVve----ttWGKRNarpi--qkgVTVVTLSLAAFAMLIRV 1073 Ustilago maydis 521
EDJ98420      191 IVFTCLSSlg----tgFNVNVl-------hMRPWIFYLSFILTIMGL 226  Magnaporthe grisea 70-15
EDR11337      205 LLTAHLGGawsnwgakYSSGS---------VRFLAYTLAPIVVLCGI 242  Laccaria bicolor S238N-H82
EDO97200      156 HGTAVWRGya-----gFKTEPtgryalvglLGAMGLAVLSGVKLSLL 197  Chlamydomonas reinhardtii
ACI65377      167 WFTAFYGLmem---ipNEPKI---------LAMYGFPLLMLVPLVLI 201  Phaeodactylum tricornutum CCAP 1055/1
EED92653      157 WLATLSGLkt----liGDEDVv-------sLVIFAAPLLVAAPFTLM 192  Thalassiosira pseudonana CCMP1335

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap