Conserved Protein Domain Family
Cyt_b561_FRRS1_like

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cd08760: Cyt_b561_FRRS1_like 
Eukaryotic cytochrome b(561), including the FRRS1 gene product
Cytochrome b(561), as found in eukaryotes, similar to and including the human FRRS1 gene product (ferric-chelate reductase 1), also called SDR-2 (stromal cell-derived receptor 2). This family comprises a variety of domain architectures, many of which contain dopamine beta-monooxygenase (DOMON) domains. The protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.
Statistics
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PSSM-Id: 176490
View PSSM: cd08760
Aligned: 108 rows
Threshold Bit Score: 58.8954
Threshold Setting Gi: 226462380
Created: 30-Mar-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative heme
Feature 1:putative heme binding sites [chemical binding site]
Evidence:
  • Comment:four conserved histidines may be involved in heme coordination

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     #
Q6ZNA5     320 LNTSYYIFLADGAANdgriykhsqqplityek--------------------------ydvtdspkniggshsvlLLKVH 373  human
EAA34055   303 PNTSNNNNNLLGTSTkplsasgw--------------------------------------------ldkvtanpLPKTH 338  Neurospora crass...
EAW13436   178 KYGRFSIDMTHATGGsgglpdlyessig----------------------------------srldggvsndsnwPAIIH 223  Aspergillus clav...
EEH10710   237 LGTSDSPTSAGGLVSsir------------------------------------------------------envMQSIH 262  Ajellomyces caps...
EER28920   185 GHGGFYLNMADGRSAsfprtdlkmlmidrgs----------------------------ahpedpqsnsesirrfLFQVH 236  Coccidioides pos...
EAT86293   185 DYDVFELDMTMGHNVdgspvapelvdngrk-------------------------------sigagtdsswkpsqLFAIH 233  Phaeosphaeria no...
EAU29243   209 FVGSFTMDMVRATGGsgvlptsykttvg----------------------------------savngeistdsnwPSIIH 254  Aspergillus terr...
EAU34773   156 ANRAQTFDKAESDSVlmfhdaygivegdmdeallsstdelipairpgettgfvllnengdlkshkgsplpsswpsPGTIH 235  Aspergillus terr...
EEH46880    31 SNYMESLESDTSTATitnilvq-----------------------------------------------cinfqkRQKLH 63   Paracoccidioides...
EAA62967   763 GWGRFYVDMARSTSKdnsapsippirpgita-----------------------------lgvsdipggwswlnpTVHIH 813  Aspergillus nidu...
Feature 1                                              #                                   #   
Q6ZNA5     374 GALMFVAWMTTVSIGVLVarffkpvwskafllgEAAWFQVHRMLMFTTTVLTCIAFVMPFiyr----ggWSRHAGYHPYL 449  human
EAA34055   339 AFFMTVAFLILFPLGVILirs----------ssSGNAFQRHWLVQALASIFTLAGAGVGLym-----tgRHIPSTAHQWL 403  Neurospora crass...
EAW13436   224 GVALCGAFILLMPAGVILlr------------vAPGSVRWHWINQTVASVIAIIGLGIGFwlst-mytkSQSFNSSHQII 290  Aspergillus clav...
EEH10710   263 GFVMFIAFFILFPLGTIAmr-----------sgSSKSFKYHWSIQLVAALFAWSGAIIGLl-------mDHNINTLHQWI 324  Ajellomyces caps...
EER28920   237 GFVLAVVFTLIMPLGVGFir-----------qgGESAFSRHWVVQASAVIGAIGGMSIALlisk-kliqLGDAHGTHKLI 304  Coccidioides pos...
EAT86293   234 GLLLASAFVVLMPLGVAGir-----------tgRPNAFKIHWVIQLSAVAFAVSGTAWGIyltwghpitIATSNGAHKIL 302  Phaeosphaeria no...
EAU29243   255 ALCLCGALILLMPTGVVFlr------------iSPGSVRWHWINQSLATVIAGIGIAIGFylst-mytkSQSYGSAHQIL 321  Aspergillus terr...
EAU34773   236 GVVMGVAFMGCFPVGGMLiq-----------lpLGRAFTYHWMIQLCALLLALGSAGYMVt--------RSTHFDLHKIL 296  Aspergillus terr...
EEH46880    64 GLIMTLVFMIIYPLGALSlhl---------plkLRVPLNFHLPIQIVGVIMMVAATALGIrlal-evhlWNLLRAHVALG 133  Paracoccidioides...
EAA62967   814 GFLMSAAFLILYPAGLVAmw-----------sgSSMSFKYHWIIQLLASLFVLIGGAIGLi-------rAHKIDSFHHFI 875  Aspergillus nidu...
Feature 1                                               #                                      
Q6ZNA5     450 GCIVMTLAVLQPLLAVFRPPLHdp-----rRQMF----NWTHWSMGTAARIIAVAAMFLGMDLpglnl---------pds 511  human
EAA34055   404 GLAITFLLVVQVILGWRHHMDFlr----irRRTWi---SHGHIWLGRWAVVAGWVNVVLGLLLsghs------------r 464  Neurospora crass...
EAW13436   291 GILVAIAMIAQWGIGFWHHRLYklr---qaPTYF----GVFHRYFGHIVMFIAIVNGGIGLRWssas------------t 351  Aspergillus clav...
EEH10710   325 GVFLGAYLFIQGLLGWQHHRVFvr----irRRHWv---SYSHIWFGRLTLVLGWTNIITGMLLsg--------------- 382  Ajellomyces caps...
EER28920   305 GICLLLAILVQPCIGYWHHLAFlk----lkRRTSv---TYAHIYFGRAVLMLAWLNIALGLYIah--------------- 362  Coccidioides pos...
EAT86293   303 GLTLLVSVVLTPMLGYLHHVRYlk----lgRATGv---TVWHRRFGASTLASAWVNVLLGLWIag--------------- 360  Phaeosphaeria no...
EAU29243   322 GIVVLLAIAAQWALGFWHHYMYk-------RTQSptplGSVHRYFGYVIFFVAILNGGIGLTWsyas------------k 382  Aspergillus terr...
EAU34773   297 GLTVVGALAVQAAMGYKHHTVFvri---aqRSAY----TLVHRWLGRSLLLLGTVNVALGLYHkrrp-----------tg 358  Aspergillus terr...
EEH46880   134 TLAIGAILIIQPTLGIIQSRCSelgv-ednKSNLc---GVMHRWIGRGAILLGMANAGIGFLVvgigtsi-----eegsl 204  Paracoccidioides...
EAA62967   876 GLTGVVCTTSMGFSRWLGRIFLllgwtnviTGLLl--tGHGWSLVPLAASFISVIALALVAWVwyathqckqreirpdwe 953  Aspergillus nidu...
Feature 1                            
Q6ZNA5     512 wkTYAMTGFVAWHVGTEVVLEV 533  human
EAA34055   465 vdVWGVGIFVGMEAVVVAWWVW 486  Neurospora crassa OR74A
EAW13436   352 gtMVGYSIAVAVVCVPVICAVA 373  Aspergillus clavatus NRRL 1
EEH10710   383 tsTTWIASMAGLIAVNALVLSF 404  Ajellomyces capsulatus G186AR
EER28920   363 vpFLIWLAWIACMLLAIVGMLR 384  Coccidioides posadasii C735 delta SOWgp
EAT86293   361 qpVWYFLVAIGVMACSALAIYF 382  Phaeosphaeria nodorum SN15
EAU29243   383 svVIGYSVVVAILGAGLIAIFG 404  Aspergillus terreus NIH2624
EAU34773   359 aiMAWFVIWLAELVAYAWVMRQ 380  Aspergillus terreus NIH2624
EEH46880   205 trSFVLMGVFTSLWFLVVLVDF 226  Paracoccidioides brasiliensis Pb18
EAA62967   954 geDSPFSLQPTRDDYFAVAADD 975  Aspergillus nidulans FGSC A4

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