Conserved Protein Domain Family
C2_Dock-D

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cd08697: C2_Dock-D 
C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
Dock-D is one of 4 classes of Dock family proteins. The members here include: Dock9/Zizimin1, Dock10/Zizimin3, and Dock11/Zizimin2/ACG (activated Cdc42-associated GEF). Dock-D are Cdc42-specific GEFs. In addition to the C2 domain (AKA Dock homology region (DHR)-1, CED-5, Dock180, MBC-zizimin homology (CZH) 1) and the DHR-2 (AKA CZH2, or Docker), which all Dock180-related proteins have, Dock-D members contain a functionally uncharacterized domain and a PH domain upstream of the C2 domain. DHR-2 has the catalytic activity for Rac and/or Cdc42, but is structurally unrelated to the DH domain. The C2/DHR-1 domains of Dock180 and Dock4 have been shown to bind phosphatidylinositol-3, 4, 5-triphosphate (PtdIns(3,4,5)P3). The PH domain broadly binds to phospholipids and is thought to be involved in targeting the plasma membrane. The C2 domain was first identified in PKC. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions.
Statistics
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PSSM-Id: 176079
View PSSM: cd08697
Aligned: 19 rows
Threshold Bit Score: 273.043
Threshold Setting Gi: 221116647
Created: 7-Apr-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_416974     649 YNNHLYVYPKHLKYDsqksfakARNIAICIEFKDsDEEDSLPLKCi---yGRPGgp-ifTRSAFAAVLHHh-qNPEFYDE 723  chicken
NP_609125     793 FCNHLYVYPLSLQFDsqklfsrARNITVVVELRDgDGEYSKPLKCiy-grPGQDl----LVSQIACPVLHhnvTPTWYEE 867  fruit fly
XP_002593326  789 YKNNLYIYPLILKFDnqktfakARNIACCVEFRDsDDEDALPLKCi---ySRPGcp-vfTTSANAAVLHHn-tTPDFYEE 863  Florida lancelet
XP_001946761  636 YINHMYVYPLSLAFDtqkniprARNITCMVQLFDsDNIDSKPIKCi----YGAHgq--lLSSMCTNVLYHs-tNPIWYDE 708  pea aphid
XP_001604470  623 YTNHLYVYPQNLLFDtqkifsrARNIACIVEMKDnDTENAQPLRCi---yGRPGta--lLISRISCPVLHhstTPSWYEE 697  jewel wasp
CAF93418      703 YKNQLYIYPQQLKYDnqktftkARNIAVCIQFRDsDDEGAASLRCiy-gkPGESl---fTNSAYAAVLHHn-qSPEFYDE 777  spotted green...
XP_394253     645 YINHLYVYPQTLCFDtqkiftrARNIACIIELRDdDSENTTPLRCi---yGRPGta-llCLRASCAVLHHn-aIPSWYEE 719  honey bee
XP_792492     565 YVNNLYIYPIQLKYDaqktfakARNIAMHIEFRDsDDEGAQPLRCfygrpGGSLf----TSSGSVSVLHHq-qVPEFYEE 639  purple urchin
XP_001341048  180 YKNHIYIYPKHLKYDsqksfakARNIAVCVEFRSsDEEHAKPLKCi----YGKPggpvfTTTACTTVLHHs-qNPDFYDE 254  zebrafish
XP_002424780  638 FNNHLYVYPLSLNFDtqknftrARNIACCIELRDsDSENAKPLCCi----YGRPgsvllGKQIITSVLHHn-tSPVWYEE 712  human body louse
XP_416974     724 IKIELPTQlheKHHLLFTFYHVScdnsskgstkkkdvvETQVGYSWLPLIk-------dGRVVTNDQHIPVSANLPsgy- 795  chicken
NP_609125     868 IKLRLPLGlfpEHHLLFSFYHVScnlskkr--danaafETPIGYAWLPLLq--------KNRICLEEQQLPVAATL---- 933  fruit fly
XP_002593326  864 VKIALPTQlqdRHHLLFTFYHVScdqsvkgstkkkdnvETVVGYAWLPILkdgkinlqdEESLPISAHLPPGYLTHkplg 943  Florida lancelet
XP_001946761  709 IKIRLPVHitpKHHLLFTFKHISvdgsrkk--qsnisvETIVGYSWLPLIf--------KSKINMDAKCLPVSVGLpagy 778  pea aphid
XP_001604470  698 IKIRLPLKlhyKHHLLFTFYHIScdinkk----kengiENCLGYAWLPLLtk-----grLAFIEESIKVLPVATHL---- 764  jewel wasp
CAF93418      778 VMMELPVHvheKHHVLFIFYHIScesssk---asnkgvESLVGYSWMPLLk--------DGRMQSVELQLPVAASLpngy 846  spotted green...
XP_394253     720 IKIRLPPKlhaKHHLLFSFYHIScdmnkk----kengvENCVGYAWSPLLhkg----rlNVDMDMNVQTLPVATHL---- 787  honey bee
XP_792492     640 VKLALPTQlnsKHHLLFRFYHVScetgkgt-vkkketvDSFVGYSWIPLLd-------kAQKLNNGEITVPVAASMpn-- 709  purple urchin
XP_001341048  255 VKIELPTHlheKHHILFSFYHVTcdinaktsskkkealELPVGYAWLPLLk--------DGRISSQDFSIPVSCTLpagy 326  zebrafish
XP_002424780  713 VKLRLPIHlkpEHHLLFTFYHVSceinkk----kengvESCVGYAWLPLLh--------KGRLCVEEQTLAVALHLpp-- 778  human body louse
XP_416974     796 -------------lsyQEVGVGKHS---------------GPEIKWVDGGk---------------------qLLKISTH 826  chicken
NP_609125     934 ----------------PVGYLSIQP---------------LGWGKGNCGPdiqwi-------------dnqrnLYTVGLR 969  fruit fly
XP_002593326  944 -------------mgkDMHMNNFYShc-----------ekVDSSSGGSDLd---------------------mCKFLKSL 978  Florida lancelet
XP_001946761  779 ------------lsvqPFGLGKGYC---------------GPEVCWIDGQk---------------------pLFSFKCH 810  pea aphid
XP_001604470  765 ----------------PDGYLSIQPlglg-------kgnaGPEILWIDSQk---------------------pIFTISVQ 800  jewel wasp
CAF93418      847 lcqdtkkvrrrsskrvLDSHVSQSQil-----------cpPPQSHPDIKWven-----------------akpLFKVRIH 898  spotted green...
XP_394253     788 ----------------PPGYLSIQP---------------LGLGKGNAGPeiiwv-------------dsqrpVFTVAFQ 823  honey bee
XP_792492     710 ---------------gYLSSKGGQGk--------------TPEVKWVDGGk---------------------pLLKVDLK 739  purple urchin
XP_001341048  327 l-----------hikePSSTKDPHLnrffqqcqkreaeisQPPTSNFLNClkgllsmekihaiirflpvifnqLFKVLTQ 395  zebrafish
XP_002424780  779 ---------------gYLSIQPLGLgrg----------naGPDITWIDGQk---------------------qIFTVGFQ 812  human body louse
XP_416974     827 LVSTVYTQDQHL 838  chicken
NP_609125     970 LDSTVLTADQHL 981  fruit fly
XP_002593326  979 HAADECTVVQFL 990  Florida lancelet
XP_001946761  811 LLSSIYSSDNHM 822  pea aphid
XP_001604470  801 MSSTVFTKDLHL 812  jewel wasp
CAF93418      899 VASTIYAQDLYL 910  spotted green pufferfish
XP_394253     824 LISTVFTRDVHL 835  honey bee
XP_792492     740 PVTTIYSTDPHL 751  purple urchin
XP_001341048  396 NDSDEVTTSTTR 407  zebrafish
XP_002424780  813 LVSTVITRDLHL 824  human body louse
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