Conserved Protein Domain Family
C2_Dock-C

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cd08696: C2_Dock-C 
C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
Dock-C is one of 4 classes of Dock family proteins. The members here include: Dock6/Zir1, Dock7/Zir2, and Dock8/Zir3. Dock-C members are GEFs for both Rac and Cdc42. In addition to the C2 domain (AKA Dock homology region (DHR)-1, CED-5, Dock180, MBC-zizimin homology (CZH) 1) and the DHR-2 (AKA CZH2, or Docker), which all Dock180-related proteins have, Dock-C members contain a functionally uncharacterized domain upstream of the C2 domain. DHR-2 has the catalytic activity for Rac and/or Cdc42, but is structurally unrelated to the DH domain. The C2/DHR-1 domains of Dock180 and Dock4 have been shown to bind phosphatidylinositol-3, 4, 5-triphosphate (PtdIns(3,4,5)P3). The C2 domain was first identified in PKC. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions.
Statistics
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PSSM-Id: 176078
View PSSM: cd08696
Aligned: 15 rows
Threshold Bit Score: 269.607
Threshold Setting Gi: 47217515
Created: 8-Apr-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_524725      14 ARNLLYIYPQSLNFAnrq----gsARNITVKVQFMYgEDPSNAMPVI--FGKSscsefSKEAYTAVVYHn---------- 77   chimpanzee
CAG10895      260 YRNLLFVYPQRVNFVnrl----tsARNITIKIQFMSgEDPTSALPVIfgKSSGpe--fLHEVYTPVTYHnkqvstllsgn 333  spotted green...
XP_002573908 1065 YRNLLYVYPRSVSLPpsk---qasSRNITVRVQLMYsDSAVTKVLPAi-YGKSnsprfICDAFTTVLYHn---------- 1130 Schistosoma m...
BAC03410      259 YRNLLYVYPQRLNFVnkl----asARNITIKIQFMCgEDASNAMPVIfgKSSGpe--fLQEVYTAVTYHn---------- 322  human
XP_424926     492 YRNLLYVYPQRLNFAnrp----asARNITIKIQFMCgEDPSCAMPVIfgKSSGpe--fVQEMYTAITYHn---------- 555  chicken
CAQ14116      496 YRNLLYVYPLRLNLTnrl----tsARNITVKIQFMSgEDSSCAMPVIfgKSSGpe--fLTEVYTPVTYHn---------- 559  zebrafish
NP_509219     589 YKNVIFVYPKHINLSnrt----gnARNIMIKIELMDaNETAQEVVFE--NGSTrm-sfLTSAKTSVIYHn---------- 651  nematode
XP_002432009  569 FRNLLYVYPKELNFTnrgirdlgsARNLTIKVELKSgENESLPYIFG--KSCCpe--fTTEAYTSVSYHn---------- 634  human body louse
NP_608489     589 YRNLLFVSPKELNFSsra----gsARNIAVRVQLMAgETPKDAVNAI--YGKSscpkfSTEAFTAVNYHn---------- 652  fruit fly
XP_001894880  613 MRNLLYVYPRSVNLSsrs----gpSRNIAIHVELMN-AQEKPIYAIFg-KSSGpn--iTFSADTAVSYHn---------- 674  agent of lymp...
XP_524725      78 -rSPDFHEEIKVKLPATltdHHHLLFTFYHVScqqkq---ntplETPVGYTWIPMLq---------------------NG 132  chimpanzee
CAG10895      334 rlSPDFYEEVKLALPAClteRHHLLFTFYHIRcqqkqn-qtgscETLIGYSKLPPQvppvkwmeghkglfnleimavsSI 412  spotted green...
XP_002573908 1131 -rSPEFFDEIKIQLPGNleeNHYLLFTFYHVIcqtkklessaslETVIGYSWLPLLe---------------------QG 1188 Schistosoma m...
BAC03410      323 -kSPDFYEEVKIKLPAKltvNHHLLFTFYHIScqqkq---gasvETLLGYSWLPILl---------------------NE 377  human
XP_424926     556 -kSPDFYEEVKIKLPAKlteKHHLLFTFYHIScqpkq---gasvETLIGYSWLPILl---------------------ND 610  chicken
CAQ14116      560 -rSPDFYDEIKILLPARltdKHHLLFTFFHIScqqkqn-qtgsvEALIGYSWLPMLn---------------------ND 616  zebrafish
NP_509219     652 -rTPHFTDEIKLSLPCDlndGHHLLFTVYHISckegd---ssstESPIGYTWLPLYr---------------------NG 706  nematode
XP_002432009  635 -kCPSFYDEIKIKLPSKlgpQHHLFFTLCHISckkkp--enppvETPVGYTWIPLLs---------------------VD 690  human body louse
NP_608489     653 -kCPSFYDEIKIALPASikqHHHLLFTIYHVScqkkpqdlqpsvETPIGYTWLPLLe---------------------DG 710  fruit fly
XP_001894880  675 -kTPTFCDEIKINLPVDlndGHHLLFTFFHITckank--vgdevKIPIGYSWIPLLk---------------------DG 730  agent of lymp...
XP_524725     133 RLKTGQFCLPVSLEKpp--------qAYSVLSPEVp------LPGMKWVDNHk----gVFNVEVVAVSSIHTQDPYL 191  chimpanzee
CAG10895      413 HTQDNHLERFFTLCH-----------ALEGGATFPlrvgeekIPENKLEHEL------KLSIISLSSSSLEPLVLYL 472  spotted green pu...
XP_002573908 1189 CLKDHDVNLLVSVEKpppalamikpdIKSISEKFC-------MDACKWVDAHr----eLFNVSTTVVSSVYMQDTSL 1254 Schistosoma mansoni
BAC03410      378 RLQTGSYCLPVALEK-----------LPPNYSMHSae----kVPLQNPPIKWaeghkgVFNIEVQAVSSVHTQDNHL 439  human
XP_424926     611 RLQTGHYCLPVALDK-----------LPFHYSIHSpe----kVPSQTPPIKWveghkgVFNIEVQAVSSVHTQDNHL 672  chicken
CAQ14116      617 RLQTSQQCLPIVLDK-----------LPINYSLHTpe----kLPAQVPPVKWlenhkgLFNLELQAVSSVQTQDSHL 678  zebrafish
NP_509219     707 KLRSGNFHLPVCGEK-----------PPPRYGYLDan---naLPNLKWVDNHk----pIFSCSTEVISSVHAQDEFL 765  nematode
XP_002432009  691 RLRSGELSLPVMMEP-----------PPSNYCYITpd---vlLPGTRWFDNHr----gVFLVNIEATSSVHPQDKYL 749  human body louse
NP_608489     711 KLKFGEFNLPVMVES-----------PPENYSFIPpn---vhLPGIKWLDNHr----aVFSINVEAVTAIHTLDSFL 769  fruit fly
XP_001894880  731 RLQTGEFALPIALEQlp--------qSYGYLSPDVn------LPNVKWLEGHk----pLFDIKLEAVTTVHTQDSHL 789  agent of lymphat...
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