Conserved Protein Domain Family
C2_Dock-B

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cd08695: C2_Dock-B 
C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
Dock-B is one of 4 classes of Dock family proteins. The members here include: Dock3/MOCA (modifier of cell adhesion) and Dock4. Most of these members have been shown to be GEFs specific for Rac, although Dock4 has also been shown to interact indirectly with the Ras family GTPase Rap1, probably through Rap regulatory proteins. In addition to the C2 domain (AKA Dock homology region (DHR)-1, CED-5, Dock180, MBC-zizimin homology (CZH) 1) and the DHR-2 (AKA CZH2, or Docker), which all Dock180-related proteins have, Dock-B members contain a SH3 domain upstream of the C2 domain and a proline-rich region downstream. DHR-2 has the catalytic activity for Rac and/or Cdc42, but is structurally unrelated to the DH domain. The C2/DHR-1 domains of Dock180 and Dock4 have been shown to bind phosphatidylinositol-3, 4, 5-triphosphate (PtdIns(3,4,5)P3). The C2 domain was first identified in PKC. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions.
Statistics
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PSSM-Id: 176077
View PSSM: cd08695
Aligned: 13 rows
Threshold Bit Score: 335.119
Threshold Setting Gi: 156356915
Created: 8-Apr-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
NP_001135632  419 IRNDLYVTLERGDFErggksvQKNIEVTMHVLYADGENLRDCVSLGTGepPRTQYHSFVLYhnnSPRWGELIKLPIPIDr 498  western clawe...
XP_002597359  305 IRNDLYVTLERAEFEkggkttGKNVEVTMVVLAEDGEVLQECISLGEGetYTSEYQSYVLYhnnNPRWGETIKLAIPIDk 384  Florida lancelet
XP_414263     430 IRNDLYLTLEKGDFErggksvQKNIEVTMYVLYADGEILKDCISLGSGepSRSAYHSFVLYhnnSPRWGEIIKLPIPIDr 509  chicken
Q8N1I0        400 MRNDLYITIERGEFEkggksvARNVEVTMFIVDSSGQTLKDFISFGSGepPASEYHSFVLYhnnSPRWSELLKLPIPVDk 479  human
Q8CIQ7        420 IRNDLYLTLEKGDFErggksvQKNIEVTMYVLYADGEILKDCISLGSGepNRSSYHSFVLYhsnSPRWGEIIKLPIPIDr 499  house mouse
XP_416024     398 MRNDLYITVERGEFEkggksvARNVEVTMHVVDSSGQILRDFISFGSGepPASEYHSFVLYhnnGPRWAELLKLPIPVDk 477  chicken
CAG11288      503 TRNDLYLSVERGEFErggksvQKNIEVTLYVLYADGDTLKDCISLGSGepNASEYRSFVLYhnnGPRWNEMVKLPIPIDr 582  spotted green...
XP_001943146  289 VRNDLYLTLERGEFEkggkstGKNIEVSIVVLDYEGNVVPDCIWGASGtdSSSEYRSMIIYhhnAPCWMETIRLAVPIEk 368  pea aphid
NP_001159700  426 MRNDLYMTLEKGEFEkggksvARNVEITIYALDADGQILKGFVAVGSGepGGDEYHTFVLYhnnSPRWAEQIKLPIPVDm 505  zebrafish
XP_562267     269 VRNDLFLTLERGEFErvgistAKNIEITALVLDENGRMVQECIAIASGspLQAYYKSMVLYhnnSPAWNETIRMFVPIDk 348  Anopheles gam...
XP_001623972  357 VRNDVYVTIEKGEFEksgkttAKNVEVSMSVIGANGRLIEDCIYLGAGgkPCTEYESFIYYhnsSPKWNETVKVRIPSDk 436  starlet sea a...
NP_733258     435 VRNDLFLNLERGEFErggkntGKNILVTVVVLDVAGNVLTDCLWGASGmeSQPQYRSMILYhqnAPSWNEMLRLSVPIDk 514  fruit fly
XP_002405678  371 VRNDLYLTLDRGEFEkggkstGKNIEATVLLVAADGQLLQGCLSSGTGeePCSEFRSLVLYhnnNPRWSDTVKVSIPMEm 450  black-legged ...
NP_001135632  499 frGSHLRFEFRHCStkd--kgeKKLFGFSFTPLMrddGTTLSDDIHELYVYKCDen-sTFNNHALYLg-LPCCKDDMSGc 574  western clawe...
XP_002597359  385 fyGSHLRFEFRHCStkd--kdvKKLFAFAFTPLMivdGTTLQDKQHELYVYKCEen-vKFHSPAMYVanLPSSGEDTIGt 461  Florida lancelet
XP_414263     510 frGSHLRFEFRHCStkd--kgeKKLFGFAFTPLMrddGTTLSDDIHELYVYKCDen-sTFNNHALYLg-LPCCKEDYNGc 585  chicken
Q8N1I0        480 frGAHIRFEFRHCStke--kgeKKLFGFSFVPLMqedGRTLPDGTHELIVHKCEen-tNLQDTTRYLk-LPFSKGIFLGn 555  human
Q8CIQ7        500 frGSHLRFEFRHCStkd--kgeKKLFGFAFSPLMrddGTTLSDDIHELYVYKCDen-sTFNNHALYLg-LPCCKEDYNGc 575  house mouse
XP_416024     478 frGAHIRCEFRHCStke--kgeKKLFGFSFVPLMqenGRTLPDGTHELIVHKCEen-aNLQDSSRYLk-LPFSKGIFLAn 553  chicken
CAG11288      583 frGSHLRFEFRHCStkd--kgeKKLFGFAFTPLMredGTTLSDEVHELYVYKCDen-aTFSNQGLYLs-LPCCKEDFNSc 658  spotted green...
XP_001943146  369 ynIAHIRFEYRHCStrdk-adnKKLFGISFARLMepeEATLQDGVHELFVYRCDe--rTKPHPVDYLg-LAASVHESSTw 444  pea aphid
NP_001159700  506 frGSHVRFEFRHCStkd--kgeKKLFGFSFVPLMqedGRTLPDGTHELIVHKCEen-aNLQDCSRYLk-LPFSKSNLPGn 581  zebrafish
XP_562267     349 fsKAHVRFEFRSCStrd--ksdPKLFGFSFARLMepgGATIADGAHELYVYKCEd--aLKVQPNVYLr-LPCSAGDRQAq 423  Anopheles gam...
XP_001623972  437 fvGSLLRFGFRHVSkfeekhkeLKTFAFSFVKLMgedETTLPDGSHELCMYKFDs--nSYFDSKAFIn-MPSLVSEVGNm 513  starlet sea a...
NP_733258     515 fsTAHVRFEFRHCStrd--ktePKLFAFSFARLMdtgGATLGDGLHELYVYKCEd--pAKLQVANYLr-LQCRPRDAQAk 589  fruit fly
XP_002405678  451 fdGSHIRIEFRHCSard---kdRRLLGFSFLPLMdeqGTIIRNGSHELYVYKADdswqKALEAAQYRg-LATGPRSGDGl 526  black-legged ...
NP_001135632  575 pnipssl-ifqrsakeTFCISTQLSSTKLTQNVDL 608  western clawed frog
XP_002597359  462 igqsevgatfprspkeTFVISTVVCSTKLTQNVDL 496  Florida lancelet
XP_414263     586 pnipssl-ifqrstkeSFSVSTQLSSTKLTQNVDL 619  chicken
Q8N1I0        556 nnqam------katkeSFCITSFLCSTKLTQNGDM 584  human
Q8CIQ7        576 pnipssl--ifqrskeSFFISTQLSSTKLTQNVDL 608  house mouse
XP_416024     554 nsqav------kttkeSFWITSFLCSTKLTQNGDM 582  chicken
CAG11288      659 pnlpanl-pfqrspkeTFWVSTILCSTKLTQNVDL 692  spotted green pufferfish
XP_001943146  445 tsspepgsvfscshkeIMTIRTMLCSTKLTQNVDL 479  pea aphid
NP_001159700  582 nqtv-------kgtkeSLWITSFLCSTKLTQNGDM 609  zebrafish
XP_562267     424 gdspsp---yhrsskeAFYVRTILCSTKLTQNGDL 455  Anopheles gambiae str. PEST
XP_001623972  514 kysqmer--lsrsskdSFSVRTLVCSTKLTQNVDL 546  starlet sea anemone
NP_733258     590 mdcggc---fsrsskeVFVLRSLLCSTKLTQNADL 621  fruit fly
XP_002405678  527 vpgsqga-gagrspreALHVTTLLCSTKLTQNGAL 560  black-legged tick
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