3L4C


Conserved Protein Domain Family
C2_Dock-A

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cd08694: C2_Dock-A 
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C2 domains found in Dedicator Of CytoKinesis (Dock) class A proteins
Dock-A is one of 4 classes of Dock family proteins. The members here include: Dock180/Dock1, Dock2, and Dock5. Most of these members have been shown to be GEFs specific for Rac. Dock5 has not been well characterized to date, but most likely also is a GEF specific for Rac. In addition to the C2 domain (AKA Dock homology region (DHR)-1, CED-5, Dock180, MBC-zizimin homology (CZH) 1) and the DHR-2 (AKA CZH2, or Docker), which all Dock180-related proteins have, Dock-A members contain a proline-rich region and a SH3 domain upstream of the C2 domain. DHR-2 has the catalytic activity for Rac and/or Cdc42, but is structurally unrelated to the DH domain. The C2/DHR-1 domains of Dock180 and Dock4 have been shown to bind phosphatidylinositol-3, 4, 5-triphosphate (PtdIns(3,4,5)P3). The C2 domain was first identified in PKC. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions.
Statistics
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PSSM-Id: 176076
View PSSM: cd08694
Aligned: 11 rows
Threshold Bit Score: 345.542
Threshold Setting Gi: 291245015
Created: 8-Apr-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3L4C_A         25 VRNDIYVTLVQGDFDkgskttAKNVEVTVSVYDEDGKRLEHVIFPGAGdeAISEYKSVIYYqvkQPRWFETVKVAIPIEd 104  human
XP_423933     431 VRNDIYVTLVQGDFDkgskttAKNVEVTVSVYDEDGKRLESVIFPGAGdeAISEYKSVIYYqvkQPRWFETVKVAIPIEd 510  chicken
NP_001103481  423 VRNDIYVTLVQGDFDkgskttPKNVEVTMSVHDEDGKKLESVIFPGAGdeGILEYKSVIYYqvkQPRWYETIKVAIPIEd 502  zebrafish
XP_002121385  424 VRNDLYVTIVQGEFEkgikssQKNVEVTMCVCNDEGHVIPMVVSMGSGenSESQYRSHIYYqnkSPKWMETVKVVIPIEd 503  Ciona intesti...
XP_002426407  422 VRNDLYLTLVSGDFSkgvkntDKNIQVTVTVCNEKGQIIPGVIYMGGGvePLNEFKSVIYYhddKPKWNEIFKVAVPIEe 501  human body louse
XP_002404881  417 VRNDLYLTLVQAEFSkgtkssDRNIEVTVKVCNEKGTIIPGVISVGSGseNLDEYHSVIYYhedRPRWMETFKIAVPIEl 496  black-legged ...
XP_313591     449 VRNDLYLTLVSGEFSkgskssDKNIEVTAYVCNKHGVAIPGVISYGGGgnALNEYKSVIYYhedRPKWGETFKIDVPIEe 528  Anopheles gam...
EFA10254      428 VRNDLYLTLIKGEFSkgsktcDKNVEVVVRVCNEEGVPIPGVIALGSGvpPIDEYKSMIYYhedKPHWYETFKVAIPIEe 507  red flour beetle
XP_785550     426 VRNDVYITILQGDFDrgarpkARNVEVNVSVCTEDNTILENAISLASGepSDSKYRSVVYYqvkNPKYHEIFKVAIPIDq 505  purple urchin
NP_477144     443 VRNDLYLTICSGEFAriaktsEKNVEVSVCVANEQGYLMPGVLSIGAGhqPIDEYKSVVYYhddKPKWQETFKIHVPIEd 522  fruit fly
XP_002742393   38 VRNDIYVTLNYGDFDrgnkksYKNVEVSVIVCDAAGKLIKDIICKGAPqeLIDEFKSTVYYqvrGPRWFETIKVQLPIDv 117  Saccoglossus ...
3L4C_A        105 v----nRSHLRFTFRHRSsqdskdksEKIFALAFVKLMrydGTTLRDGEHDLIVYKAEa--kKLEDAATYLs----LPST 174  human
XP_423933     511 v----nRSHLRFTFRHRSsqdskdksEKIFALAFVKLMrydGTTLRDGEHDLIVYKAEa--kKLEDASTYLs----LPST 580  chicken
NP_001103481  503 v----nRSHLRFTFKHRSsqdckdksEKNFALSFVKLMrydGTTLRDGEHDLIVYKAEa--kKLEDSSMYLs----LAST 572  zebrafish
XP_002121385  504 f----ySAHLRFTYRHRStfenkdkaEKDFGLSYVRLMkseGTTLQDGVHNLLVYKVEsrrlEPNDAKKYLs----LPPS 575  Ciona intesti...
XP_002426407  502 f----kSSHIKFTFKHRSsnetkdksEKPFAMSFMKLMqenGTTIPDTKHTLCVYKIDhk-kFDETDIGYLs----LPWT 572  human body louse
XP_002404881  497 f----ySAHLLFMFKHRSsneakdraEKPFAMSFVKLMqenGTTLNDEVHELLVYRVSer-mGLFDMEAYFeenssTPNV 571  black-legged ...
XP_313591     529 f----kQCHLRFTFKHRSsneakdrsEKPFGLSYVRLMnddGTTLQHKRHTLLVYKIDhkkyDDETQFNYLs----LPSL 600  Anopheles gam...
EFA10254      508 f----kTSHLKFTFKHRSsneakdknEKPFAMSYVRLMqenGTTLKDARHNLIVYKIDyk-kFDEKGLDYFk----LPSI 578  red flour beetle
XP_785550     506 fc--knNTHVRFTFRHRSateakdkqEKIFAMAYLRLMtdiGTTITNGIHELIVYKVRacdkNMESSTAYLn----LPST 579  purple urchin
NP_477144     523 f----kQCHLRFVLKHRSsneqkdrtEKPFGLAYVRLMqanGTTITQGQHILAVYKIDhkkyDKTVANCYLe----LPAT 594  fruit fly
XP_002742393  118 pieqlhGTHLKFSFRHRSskeakdkdEKVFAISFLKLLhenGTSVVSGTHDLLVYKVDg--kLPNNAKSYLe----LPAT 191  Saccoglossus ...
3L4C_A        175 KAELEEkghsatgksmq-------slgsctiskdSFQISTLVCSTKLTQNVDL 220  human
XP_423933     581 KIELEEkghsatgksmq-------nlgsctiskdSFQISTLVCSTKLTQNVDL 626  chicken
NP_001103481  573 KPEMEErnpssgknaq--------nlgsftiskdSFQISTLVCSTKLTQNVDL 617  zebrafish
XP_002121385  576 RSDLDSykskpgaspsgqsrlfnsrvegftlsrdTFQISTLVCSTKLTQNVDL 628  Ciona intestinalis
XP_002426407  573 RPDEKIdknscsg--------------lnfsnkdFFFITTNVCSTKLTQNVEL 611  human body louse
XP_002404881  572 QPNKAQlasfqagg-------------islaikdSFQISTLVCSTKLTQNVDL 611  black-legged tick
XP_313591     601 AEELPNgsskpsts------------gfslaskdSFIIETNLCSTKLTQNVDI 641  Anopheles gambiae str. PEST
EFA10254      579 VSDVKDnakpsva--------------gltmskdIFVMSSNICSTKLTQNVDL 617  red flour beetle
XP_785550     580 RQDPKAfedkpqthasg------hqkglsasskdTFLLSTVVCSTKLTQNVDL 626  purple urchin
NP_477144     595 VAELQGakpsigg--------------ltllpkdQLSIGVNLCSTKLTQSVSL 633  fruit fly
XP_002742393  192 RAEAEArgifqstqhkgg----ihhgglslhnkdNFQIATLVCSTKFPQNIDL 240  Saccoglossus kowalevskii
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