Conserved Protein Domain Family
C2_PI3K_class_I_beta_delta

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cd08693: C2_PI3K_class_I_beta_delta 
C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
PI3Ks (AKA phosphatidylinositol (PtdIns) 3-kinases) regulate cell processes such as cell growth, differentiation, proliferation, and motility. PI3Ks work on phosphorylation of phosphatidylinositol, phosphatidylinositide (4)P (PtdIns (4)P),2 or PtdIns(4,5)P2. Specifically they phosphorylate the D3 hydroxyl group of phosphoinositol lipids on the inositol ring. There are 3 classes of PI3Ks based on structure, regulation, and specificity. All classes contain a C2 domain, a PIK domain, and a kinase catalytic domain. The members here are class I, beta and delta isoforms of PI3Ks and contain both a Ras-binding domain and a p85-binding domain. Class II PI3Ks contain both of these as well as a PX domain, and a C-terminal C2 domain containing a nuclear localization signal. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. Members have a type-I topology.
Statistics
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PSSM-Id: 176075
View PSSM: cd08693
Aligned: 18 rows
Threshold Bit Score: 229.506
Threshold Setting Gi: 156386750
Created: 25-Mar-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
NP_001026482  319 TSVWDICSPFKIVLLKGNklnt---eenAKVHVRAGIFHGtelLCKTIVSTEIsg----rsDHAWNEVLEFEINVCDLPR 391  chicken
XP_001946655  311 KLSFDIDEQFKFKVNYISklncd-vtrtVEVGIEAALFHGgkaLCECVRTSEKivn---ngDCTWDEELEFDMSIADIPR 386  pea aphid
XP_001634074  317 LSLWSIETQLRVKILSADninv---gdvMMVGVRGAIYHGnevLSDIKQTKPQsg-----nKPLWNEFINLNILVCDIPR 388  starlet sea a...
XP_623897     316 VSAWKIEEPFVFTVNAISrlncdaahrtVEIGLQAGLFHGgksLCESQKTKETvvn--sdgSCEWEETLKFDIKVRDIPR 393  honey bee
XP_311141     301 ITSWEIDAKLQCTVHEIRglnv---esdKELGVQLGLFHGgksLCKTERTRTVtvn---sgAATWNETILFDINVSNVPR 374  Anopheles gam...
XP_001847784  278 ITSWEVDTQFSCVVQEIAdlncd-anrnVEVGIQLGLFHGgksLCKPMKTQLVslh---kgRAAWNETIVFDINVKNVPR 353  southern hous...
XP_002122027  335 WSLWQLDVMFKLRIIRAGnvnag-qerdKKLVVHVGLYHGtetLCPTTYTKEPvkemaagnEYQWDEECFFDINAVNLPR 413  Ciona intesti...
XP_002425033  325 LSSWTIDDRFSLKICAISrlnt---dvnRTVGIQVGIFHGgkpLCESQKTSEKavl--kdgKVDFEEELTFDIQISNIPR 399  human body louse
XP_968847     313 KSAWDIQRKFSVTLNAVSglncd-mrktNEIGIQVGLFHGgksLCERLKASIQpin--eknESFFRETLVFDILVCNIPR 389  red flour beetle
NP_650902     339 SSLWDMGNYFQLTLHSISnvnfd-ktraLKVGVHVCLYHGdkkLCAQRSTDSPngn--fdtFLFNDLVMDFDIQMRNLPR 415  fruit fly
NP_001026482  392 MARLCFAVYAVMdkmktkkstksmnpskyqtirkagkvhYPVAWVNTMVFDYKgQLKNGEFVLHSWssfpd-eleemLNP 470  chicken
XP_001946655  387 MARLCLVVYEVSktskglrtrr-------ikeskqemfvTPMDWVNTTVYDFKnQLKSGSITLYMWtyaddlqnedlLHP 459  pea aphid
XP_001634074  389 MARLCLVLFGVYvkaaarr-------------kkknldyIPLAWVNVTLFDFRgNLRQGPLTIHAWpvpet--mpdlLNP 453  starlet sea a...
XP_623897     394 MARLCFVLYEISktakglksrrl------vkdtkqeffiNPLCWANTTIYDFKsQLKTGAMTLYTWtyaedmqnddlLHP 467  honey bee
XP_311141     375 MARLCLVVYENMrtakgtgir---------trrtkdgliNPIAWVNTMVYDYKnQLKVDSVTLYTWdyaedaqsediLHP 445  Anopheles gam...
XP_001847784  354 MARLCLVIYENVrtakgigvr---------arrtkdgfmNPIAWVNTMLYDYKsQLKAGAVTLYTWtyaedsqsedvLHP 424  southern hous...
XP_002122027  414 NAMLCLAICSSKrnvggkskrke------stqkntqhsaSPIAWANMMVFDFKrYLKAGLYRLNCWqvnhdnldsnnLSP 487  Ciona intesti...
XP_002425033  400 MARLCFAVYEISksakgvkakk-------vkdskqdlymNPLTWVNTTVYDFKnQLKTGDITLYMWtyaedsqheemLQS 472  human body louse
XP_968847     390 NAKLCFCIYEVPkssklvrtkkg------keygnnkesiTPIAWANTTVYDFKnQLRNGAMTLYMWtfandlmcediFNA 463  red flour beetle
NP_650902     416 MTRLCIVIFEVTkmsrskkssnnk----dialkdvpynkNPLAWVNTTIFDHKdILRTGRHTLYTWtyaddiqsvevFHP 491  fruit fly
NP_001026482  471 MGTVQTNPyt-eNATALHIRFQEYSKQ 496  chicken
XP_001946655  460 LGTVVSNPnv-eQTTALTITFHSYQPA 485  pea aphid
XP_001634074  454 IGTVVSNInt-sTSPCLVIEFQRYANN 479  starlet sea anemone
XP_623897     468 LGTVVSNPhi-dRAAALMLTFPNYGKE 493  honey bee
XP_311141     446 LGTVEPNPnrdnMVVSVLLSFGTYGPE 472  Anopheles gambiae str. PEST
XP_001847784  425 LGTVEPNPrr-dECSSMILCFEDYKQE 450  southern house mosquito
XP_002122027  488 RGGVMLNPdv-eQAAFIEIMMPEYQAT 513  Ciona intestinalis
XP_002425033  473 LGTVVSNTnv-dHATALTLSFKSYSTE 498  human body louse
XP_968847     464 LGNVVNNPn--kSATALTLHLIDRKNI 488  red flour beetle
NP_650902     492 LGTIEPNPrk-eECALVDLTFLSSGTG 517  fruit fly
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