Conserved Protein Domain Family
C2B_Tac2-N

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cd08692: C2B_Tac2-N 
C2 domain second repeat found in Tac2-N (Tandem C2 protein in Nucleus)
Tac2-N contains two C2 domains and a short C-terminus including a WHXL motif, which are key in stabilizing transport vesicles to the plasma membrane by binding to a plasma membrane. However unlike the usual carboxyl-terminal-type (C-type) tandem C2 proteins, it lacks a transmembrane domain, a Slp-homology domain, and a Munc13-1-interacting domain. Homology search analysis indicate that no known protein motifs are located in its N-terminus, making Tac2-N a novel class of Ca2+-independent, C-type tandem C2 proteins. The C2 domain was first identified in PKC. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions.
Statistics
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PSSM-Id: 176074
View PSSM: cd08692
Aligned: 4 rows
Threshold Bit Score: 252.156
Threshold Setting Gi: 189527023
Created: 24-Mar-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
BAC86538     289 AELELGTCFQAvnSRIQLQILEARYLPssstplTLSFFVKVGMFSsgeLIYKKKTRLLKAsnGRVKWGETMIFPLIqsek 368 human
NP_001088877 347 AELQVGTCFQAinSRIQLQILKAQNLPnsstplSINFFVKVEMFStegLLNKKKTRSLKVtnGQVNWGETMIFPVTlkee 426 African clawed ...
XP_696074    337 AELQLALCFQPvnSRMQLQILSTQNLPssssplTQSYFVKVDLLGegkFLLKRKTKAVKSsgGQVQWGEVLHFPITsqdh 416 zebrafish
XP_421322    352 TELQIGTCFQAinRRIQLQILEAQNLPisstplSLSFFVKVGMFStegLIYKKKTRLVKStnGQVKWREMMIFPVSqaeq 431 chicken
BAC86538     369 eiVFLIKLYSRSSvRRKHFVGQIWIsedsnnieAVNQWKETvinpekvVIRWHKL 423 human
NP_001088877 427 giNFLIKLYSRGSvRRKHFIGQVWIssdsssseAADQWTDTiqhpekvVTKWHSL 481 African clawed frog
XP_696074    417 nlQLSVKLYSRSSvRRKHLLGQVLLsldssspeAVEQWKDAmanpekvVTSWHRV 471 zebrafish
XP_421322    432 giGFLIKLYSRSSvRRKHFLGQVWIssdsnnseAVEQWEDTianpekvVIKWYSL 486 chicken
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