Conserved Protein Domain Family
C2_NEDL1-like

?
cd08691: C2_NEDL1-like 
C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
NEDL1 (AKA HECW1(HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1)) is a newly identified HECT-type E3 ubiquitin protein ligase highly expressed in favorable neuroblastomas. In vertebrates it is found primarily in neuronal tissues, including the spinal cord. NEDL1 is thought to normally function in the quality control of cellular proteins by eliminating misfolded proteins. This is thought to be accomplished via a mechanism analogous to that of ER-associated degradation by forming tight complexes and aggregating misfolded proteins that have escaped ubiquitin-mediated degradation. NEDL1, is composed of a C2 domain, two WW domains, and a ubiquitin ligase Hect domain. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions.
Statistics
?
PSSM-Id: 176073
View PSSM: cd08691
Aligned: 9 rows
Threshold Bit Score: 220.353
Threshold Setting Gi: 221127302
Created: 24-Mar-2010
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
NP_001139236  213 ISFSLSDFQATGLKKGMFFNPDPYLKIAIHPgkhsifpalpHHGQEKRSGIVCNTiNPVWqRERFNFVslptDVLEIEVK 292  zebrafish
XP_002121950   16 ISFTITGLSGFNLKKGVFFNPDPYVKLRILPgpnc--rkcaHHKQRHHTKQVEDTtNPTW-KEQFYIQvlrsDIIELEVK 92   Ciona intesti...
NP_001123750  184 ISFTLSDFQALGLKKGMFFNPDPYLKISIQPgkhsifpalpHHGQEKRSKIVCNTvNPVWkRELFSFVslptDVLEIEVK 263  western clawe...
XP_421906     185 VSFTLSDIRAVGLKKGMFFNPDPYLKMSIQPgkkstfptfaHHGQERRSTIISNTtNPVWhREKYSFValltDVLEIEVK 264  chicken
Q8K4P8        205 ISFSLSDFQAMGLKKGMFFNPDPYLKISIQPgkhsifpalpHHGQERRSTIIGNTvNPIWqAEHFSFVslptDVLEIEVK 284  house mouse
XP_002163286  167 LVISMSGMKASNLKKGFFGKPNPYVKINVIPrvrhlaafqkHHGLQGKTVPKQNTiDPVWeTEAFVFSgtaaDLLEVEVC 246  green hydra
XP_002406278  136 LSTCRMHLHARNLKKGMFFSPDPYVKMGIQPglgdgvlllpHHGQICRTGAAESTvHPSW-PGQFEFIgypsDVLEFEVK 214  black-legged ...
XP_002741443  175 VTLTISEMHARTLKKGMFFNPDPYVKLSVQPgkrasfptlaHHGQDCRTSIAENTtNPVWhGEEFQFQalptDVLEMDVK 254  Saccoglossus ...
XP_001641444  201 LEFSVSGLQAEGLKKNIFGRPSPYVKLSIIPsrrhfrswkhHHGQIAKTSSQSNTiDPDWrNEEFVFLgghdDTLEIEVR 280  starlet sea a...
NP_001139236  293 DKFaksRPIIKRFLGKLSMPvqrllek-------haigdrVVSYTLGRrlptehvsGQLQFRFE 349  zebrafish
XP_002121950   93 DRFdkgRPVFRRFLGKLEVPvgeiler-------lncseqRYTGALTKrtpldhtsGSLSFVIA 149  Ciona intestinalis
NP_001123750  264 DKFaksRPIIKRFLGKLSMPvqrller-------haigdrVVSYTLGRrlptdhvsGQLQFRFE 320  western clawed frog
XP_421906     265 DKFaksRPIIKRFLGKLTIPvqrller-------haigdqILSYNLGRrlpadhvsGYLQFKVE 321  chicken
Q8K4P8        285 DKFaksRPIIKRFLGKLSMPvqrller-------haigdrVVSYTLGRrlptdhvsGQLQFRFE 341  house mouse
XP_002163286  247 NKSkprPASTRKFLGKLIFPvckiidgcglstgvdvnffkEGCARLSRrisascvsDKETLPPL 310  green hydra
XP_002406278  215 DKFarsRPIIGRFLGRLVVRiwdlldr------csggvpmELSYTLSNktppehmtGQLFFTFV 272  black-legged tick
XP_002741443  255 DKFvksRPIISRFLGKLTIPvqrller-------vhlgdhVLTYNLMKrspvdnisGQLVFKVE 311  Saccoglossus kowalevskii
XP_001641444  281 NKFsgaRPAFSRFLGKLCIPlgdi-------------fdsQGSGPLGKrtptdriqGTITFAIS 331  starlet sea anemone
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap