Conserved Protein Domain Family
C2_KIAA0528-like

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cd08688: C2_KIAA0528-like 
C2 domain found in the Human KIAA0528 cDNA clone
The members of this CD are named after the Human KIAA0528 cDNA clone. All members here contain a single C2 repeat. No other information on this protein is currently known. The C2 domain was first identified in PKC. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions.
Statistics
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PSSM-Id: 176070
View PSSM: cd08688
Aligned: 18 rows
Threshold Bit Score: 164.788
Threshold Setting Gi: 167516652
Created: 24-Mar-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
NP_055617       5 LKVKIVAGRHLPVMDRasdlTDAFVEVKFgn-tTFKTDVYLkslNPQWnSEWFKFEvdded-lqdePLQITVLDHDtysa 82   human
XP_001639653    5 VKVRIVAARDLPVMDRtsdlADAFVEVRLgn-vMNKTEVCKktlNPQWdSEWFRFEvddee-lqdePLQIRIMDYDtvta 82   starlet sea a...
XP_002108582   48 INVKIVAGRNFPVMDRasdlADAFVEVKFgs-nTYKTDVCKrtlNPSWkCDWFRFEaddee-vqdrCLEIKVLDHDtyta 125  Trichoplax ad...
NP_732985       5 VGVKIKAARNLPVMDKssetTDAFVEIKLas-vTHKTDVFRkslNPTWnTDWFRFEvddae-lqdePLQIRLMDYDtysa 82   fruit fly
XP_002573547    5 VKVRVISARNLPVMDRatflTDAFVELCIgs-iTYKTEVVRrslNPSWnSEWFCFElddra-lqdeALLLKVMDHDtysa 82   Schistosoma m...
XP_646056       5 LKVRIIEGRDLPIMDRssalADAFVEIRCgqndPQKTDIQKktlNPVW-NQDFRFDfpndvdiqdnPLDIRVWDYDlvsk 83   Dictyostelium...
XP_001891658   14 LSVRVISARGLPVMDKsnitTDAFVEVHFdn-eVYKTDVCSktlSPVWdSDVFVFEtdeqq-lfdnPVQFRVMDHDtysa 91   agent of lymp...
EEY70467        5 IKIRLVEARDMPVVDRtsklADAYVSITFas-fEAKSSVSKktlNPKW-DEEFRFDvaddsvlqsqPIEFKLMDHDvytt 82   Phytophthora ...
NP_508464      14 LEICVISAKALPVMNKsinsTDAFVEVRFle-tIDKTDVVTs-lNPVWnSEQFVFDtdere-lteeWLQLRVMDHDtysa 90   nematode
XP_828493       4 LTVTVHEARDLPVMDRttglADTYVVVKLdd-lEYTTDISRmscHPVW-NRVFRFDtpdllvlqedPLEVRVYDHDifsr 81   Trypanosoma b...
NP_055617      83 NDAIGKVYIdidplly-------seaatviSGWFPIYDT 114  human
XP_001639653   83 HDAIGKVNIslgpllt-------qdppgciNGWFPIYDT 114  starlet sea anemone
XP_002108582  126 HDAIGMVYVcltpllq-------rsssqqlSGWFPVYDT 157  Trichoplax adhaerens
NP_732985      83 NDAIGKVNIslnplclesssqavhgkgtvlSGWIPVFDT 121  fruit fly
XP_002573547   83 HDTIGRVYFdlnplls-------rgqtrclNGWFPIYDT 114  Schistosoma mansoni
XP_646056      84 NDVIGSVLIdlnvlldg------etptsqiNGWFPIYDT 116  Dictyostelium discoideum AX4
XP_001891658   92 NDAIGRVFYdvsllvskircskaddnsmefTNWLPIYDS 130  agent of lymphatic filariasis
EEY70467       83 DATVGIVYVdlncllm--------rdghviQGWFPVYDT 113  Phytophthora infestans T30-4
NP_508464      91 NDAIGRVNIdcnifmermr--maktevldeTFSFKVYDT 127  nematode
XP_828493      82 DDIVGHTFVdlnsmvl--------ksnasmSGWFPLFDT 112  Trypanosoma brucei TREU927
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