Conserved Protein Domain Family

cd08686: C2_ABR 
C2 domain in the Active BCR (Breakpoint cluster region) Related protein
The ABR protein is similar to the breakpoint cluster region protein. It has homology to guanine nucleotide exchange proteins and GTPase-activating proteins (GAPs). ABR is expressed primarily in the brain, but also includes non-neuronal tissues such as the heart. It has been associated with human diseases such as Miller-Dieker syndrome in which mental retardation and malformations of the heart are present. ABR contains a RhoGEF domain and a PH-like domain upstream of its C2 domain and a RhoGAP domain downstream of this domain. A few members also contain a Bcr-Abl oncoprotein oligomerization domain at the very N-terminal end. Splice variants of ABR have been identified. ABR is found in a wide variety of organisms including chimpanzee, dog, mouse, rat, fruit fly, and mosquito. The C2 domain was first identified in PKC. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions.
PSSM-Id: 176068
View PSSM: cd08686
Aligned: 6 rows
Threshold Bit Score: 186.174
Threshold Setting Gi: 241686255
Created: 24-Mar-2010
Updated: 2-Oct-2020
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
Q12979        506 LHVIVHSAkgfkqsANLYCTLEVdsfgyfvsKAKTRVFRdtaEPKWDEEFEIELEGSQSLRILCYEKCydktkvnkdnne 585  human
XP_415244     938 LNVIVHSAtgfkqsSNLYCTLEVdsfgyfvnKAKTRVYRdttEPNWNEEFEIELEGSQTLRILCYEKCynkmkltkedge 1017 chicken
A4II46        509 LHVIVKSAkgfshsSNLYCTLEVdsfgyfvsKAKTRVFRdttEPEWNEEFEIELEGSQCLRILCYEKCydksklnkdnne 588  western clawe...
NP_001116725  936 LNVIVHSAtglkqsLNLYCTLEVdsfgyfvnKAKTRVYRdttEPNWNEEFEIELEGSQTLRLLCYSKIkqcrd----dge 1011 zebrafish
XP_002120098  987 LNATIHSGqgflhaCNPYCTLEVdsygqfqtKAKTRPCRdtkLPVWDEEFELEVDGAQTLRILCYDRAreavag---asy 1063 Ciona intesti...
XP_002412820  407 LLITVHNLqglnrpADIFICFEVdsyghffkKARTKTCQntlEPNFNQEVVIDLDGSQTLRILCYEEHtsn--------- 477  black-legged ...
Q12979        586 ivDKIMGKGQIQLdpqtvetk-nwhtdviEMNGIKVEFSMKF 626  human
XP_415244    1018 stDRIMGKGQIQLdpqtlqdk-dwqrtviSMNGVEVKLSVKF 1058 chicken
A4II46        589 ivDKIMGKGQIQLdpqvvqsk-nwhddviEMNGIKVEFSMKF 629  western clawed frog
NP_001116725 1012 niDRVMAKGQIQLdpqslqgk-dwqrtviSMNGIEVKLSMRF 1052 zebrafish
XP_002120098 1064 ddDVLIAKGKVGLvreslrth-gekevsvLMNELSISVSIKF 1104 Ciona intestinalis
XP_002412820  478 gtTATVLRGKAAFemsrswltdkyqeksfSLQECTLNLSIKY 519  black-legged tick
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