Conserved Protein Domain Family

cd08685: C2_RGS-like 
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C2 domain of the Regulator Of G-Protein Signaling (RGS) family
This CD contains members of the regulator of G-protein signaling (RGS) family. RGS is a GTPase activating protein which inhibits G-protein mediated signal transduction. The protein is largely cytosolic, but G-protein activation leads to translocation of this protein to the plasma membrane. A nuclear form of this protein has also been described, but its sequence has not been identified. There are multiple alternatively spliced transcript variants in this family with some members having additional domains (ex. PDZ and RGS) downstream of the C2 domain. The C2 domain was first identified in PKC. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions.
PSSM-Id: 176067
View PSSM: cd08685
Aligned: 6 rows
Threshold Bit Score: 186.505
Threshold Setting Gi: 198425324
Created: 23-Mar-2010
Updated: 2-Oct-2020
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
3FBK_A        16 GQLRLSIDAqdrvLLLHIIEGKGLiskq----pgtCDPYVKISLipedsrlrHQKTQTVPdc-rDPAF-HEHFFFPvqee 89  human
XP_002191203  13 GQLKLSIEVrgrtLVLHVMEAKGLmgae----craCDSYVKMSIvpdadwkcRQKTKTVPds-kNPVF-HEHFVFPvkee 86  Taeniopygia gut...
XP_002575474 488 GKLRLDIEYqnhsIKLHVIEAKGLrttn----sqnCNSFVKISAspdkgvtfEQTTEIVEns-aTPCY-NKEFLLNlnki 561 Schistosoma man...
CAG12422       1 GQLKLSIIQqhgvLVVSVLEARGVlekg----qgsCNAYVKVGLfpggdprdRQKTRMVPdc-hNPLF-LQTFSFRvseg 74  spotted green p...
XP_002126381  13 GQLKLVVCGstnkITITILGLRSLpsts----sntNQVYVKMSLspefesrlRHKTSTYDvteeSIAM-HETFSFDicrr 87  Ciona intestinalis
XP_002121872  98 GQLKLVICGtarkLTVTFLGVRSLhksytrsgsypHYIYLKISLspdtenrvRHKTSPKClt-sDTLSvHESFSFDitrr 176 Ciona intestinalis
3FBK_A        90 ddqkRLLVTVWNRAsqsrqsgLIGCXSFgvkslltpdkeiSGWYYL 135 human
XP_002191203  87 deqkRLLVTVWNREknsredgILAVAERte---------iSGWYYF 123 Taeniopygia guttata
XP_002575474 562 kyckRIHLAIYAQLtkeldceFLGGMSFgipsiq-nkkhiSGWYYL 606 Schistosoma mansoni
CAG12422      75 dvhkRLLFTMWNSTstsrcslLLGCTSFsvcsl--ldkevRGWYYL 118 spotted green pufferfish
XP_002126381  88 dsnrRVLVSVWMKNner--tfLLGCMSFgvrsivtsqeitQGWYYL 131 Ciona intestinalis
XP_002121872 177 digkRILISAWSKCeaydrsmFIGCMSFgvkrivsnqeviQGWYYF 222 Ciona intestinalis
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