Conserved Protein Domain Family

cd08684: C2A_Tac2-N 
C2 domain first repeat found in Tac2-N (Tandem C2 protein in Nucleus)
Tac2-N contains two C2 domains and a short C-terminus including a WHXL motif, which are key in stabilizing transport vesicles to the plasma membrane by binding to a plasma membrane. However unlike the usual carboxyl-terminal-type (C-type) tandem C2 proteins, it lacks a transmembrane domain, a Slp-homology domain, and a Munc13-1-interacting domain. Homology search analysis indicate that no known protein motifs are located in its N-terminus, making Tac2-N a novel class of Ca2+-independent, C-type tandem C2 proteins. The C2 domain was first identified in PKC. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions.
PSSM-Id: 176066
View PSSM: cd08684
Aligned: 5 rows
Threshold Bit Score: 183.92
Threshold Setting Gi: 189527023
Created: 24-Mar-2010
Updated: 2-Oct-2020
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
EAW81464     106 IWITVLQCrdlswpssygDTPTVSIKGILtlpkpvHFKSSAKEgsnAIEFMETFVFAiklqnlqtvRLVFKIQTQTprkk 185 human
Q91XT6       239 IWITVLQCrdiswpssygDTPTISIKGILtlskpvHFKSSAKEgsnAIEFMETFVFAiklqnlqavRLAFKIQTQTpkkk 318 house mouse
XP_696074    224 VWITLVKCtdlsvynervEQQKIGVKGVItvnkpvRFKSTLKEaseDTVFMETFVFTlnleqirrsALVLRLQAHTprkr 303 zebrafish
XP_421322    239 IWITVLHCkglswpsgcgENPRIYVKGILtlpkpvQFKSSAKEgsnDIEFMETFVFAiklqsvqavRLVFKIQMQTprkr 318 chicken
NP_001088877 234 IWITVVKIkdfswpvscgENPSVYIKGMItlpkavPFKSSAKEgslDIELMETLVFAikrqtlqtvKLVFNVLSLTprkr 313 African clawed ...
EAW81464     186 TIGECSMslrtlstqemDYSLDI 208 human
Q91XT6       319 TIGECSLslrtlstqemEYSLEI 341 house mouse
XP_696074    304 TLGECVLslrslgpqetKHWLEF 326 zebrafish
XP_421322    319 TIGECSLslrelsseesNHWLDI 341 chicken
NP_001088877 314 TISHCSIslrdlseeetDHWLEL 336 African clawed frog
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