Conserved Protein Domain Family
C2_C21orf25-like

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cd08678: C2_C21orf25-like 
C2 domain found in the Human chromosome 21 open reading frame 25 (C21orf25) protein
The members in this cd are named after the Human C21orf25 which contains a single C2 domain. Several other members contain a C1 domain downstream of the C2 domain. No other information on this protein is currently known. The C2 domain was first identified in PKC. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions.
Statistics
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PSSM-Id: 176060
View PSSM: cd08678
Aligned: 12 rows
Threshold Bit Score: 176.018
Threshold Setting Gi: 71995216
Created: 26-Mar-2010
Updated: 17-Jan-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001846732 389 LLVKIIKAegl-----lqcSKPFCVAEMdepaqKHQSACKMg--pNPFWDDTFLFDlsnnstELLFEVYDSVavgn---f 458  southern house...
AAL13712     381 LLVKIVKGdgi-----rdaQNPYVVIEMdepaqKNQTGTQRg--gKPFWDEHFLFElspqsaEILFEVYDHPvias--dp 451  fruit fly
Q9Y426       265 LLVRNIHVlllsepgasghINAVCVVQLndpvqRFSSTLTKnt-pDLMWEEEFTFElnakskELHLQISEAGrss----- 338  human
XP_002597156 254 VVIKANGLpgrn---gygsCDPYCIIEMdaplqKHKTSVIKnt-iNPFWDEHFLFDlstrtkELKFSLFDREkgs----d 325  Florida lancelet
XP_416741    270 LLVKNITVnltdh-saagsTNLVCVAQLndpmqKFSSSVAKna-aNPFWKEEFVFElsakskTLLLQIVEDGkld----- 342  chicken
XP_002428629 410 LVITGIQAmnls----edcRNSYCILEMdeppqKYISSTQKnt-sEPVWDEQFIFNvkpgkgELLFEIYENTsk------ 478  human body louse
XP_001196546 369 LLVKVIKAngllvrsggssSDPYCIAMLdhppqRYKTNTIVnt-tNPFWDEHFLFQlngnsrELRFEVWDKGsn------ 441  purple urchin
NP_001024859 319 KVIKASRLgr-------evSQPFVNVEMdepaqKYSTTKGIn--aNPFWEETFDFDltpateEILFEIYEGNdklhmndd 389  nematode
EEZ99736     358 LLVKVVRAaqlga--stgcTEPYCVVEIdeppqKNQTSIKKst-dSPFWDEQFLFDlsqntaEVLFEVYDHAvkp----- 429  red flour beetle
CAF98555     253 LLVKNIQVtlkqqedaagsINPFCVLQLdhppqKFQSAILAknasDLAWDQPFIFElsglskELNIQLVNSGpag----e 328  spotted green ...
XP_002730448 230 LLVKVIKAnglaggnelacGNPYCLIEMdypvqKHKTASVRnt-aNPFWDEHFLFDlnnstnVIKFTVLDKDkss----q 304  Saccoglossus k...
XP_001920385  45 LLVKNIRVtftqedgaaggMNPQCILQLddppqKINSSVLSnk-sNPTWDQPFIFElsgrskELNIQVVDNGkpv----e 119  zebrafish
XP_001846732 459 qkFLGLGLVGIDelsngpastQVLELQprpy----eteNISGTLTVEFVFIDAPPAP 511  southern house mosquito
AAL13712     452 pkFLGLGLVGIDelavgpastQLLQLQprpy----etqPVSGAITVDFVFIEGAEIP 504  fruit fly
Q9Y426       339 egLLATATVPLDlfkkqpsgpQSFTLTsgsa----cgsSVLGSVTAEFSYMEPGELK 391  human
XP_002597156 326 snELGEAVIPMDmltqnlssrQIIPLQrals----nddSINASVTAEFLFMEPSAAQ 378  Florida lancelet
XP_416741    343 ssSSARATIPLDlfrkqpsghQSFALSsrasdgspglrPGRGSITAEFLFIEPSELK 399  chicken
XP_002428629 479 -kLLGMGIVGTEelmsnhtrrQMIPLQsqpf----esdRITGSIAVEVFYTPHDFII 530  human body louse
XP_001196546 442 dlFFGDAQVPVDtlehmrgsrHILPLNgvtg----dgeSVKGSLTVWFLFMESAEQN 494  purple urchin
NP_001024859 390 egFLGLAIVNFEeirrsgetvHSLKLQgrpy----rkdAISGEITVQFDFFYDPNLL 442  nematode
EEZ99736     430 nkFLGLAIVGVDelianpsqrQIISLQgapy----esdPVSGTLTVEFLFVEGADIP 482  red flour beetle
CAF98555     329 glLLGQATVPFHlakkqpsgqQTFPLLtk--------dGTKGSLTTEVGPPSQQWSI 377  spotted green pufferfish
XP_002730448 305 nqCLGGAIVSLEslrrnpstrQIIPLQgnni----qdgNVSGSITLEFLFMEPAEAQ 357  Saccoglossus kowalevskii
XP_001920385 120 scLLGQVSVPFDlvrkhpkgqQTFSLKtk--------dQVTGSITTEFTYLEPNEVR 168  zebrafish
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