Conserved Protein Domain Family
C2B_RasGAP

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cd08675: C2B_RasGAP 
C2 domain second repeat of Ras GTPase activating proteins (GAPs)
RasGAPs suppress Ras function by enhancing the GTPase activity of Ras proteins resulting in the inactive GDP-bound form of Ras. In this way it can control cellular proliferation and differentiation. The proteins here all contain two tandem C2 domains, a Ras-GAP domain, and a pleckstrin homology (PH)-like domain. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. Members here have a type-I topology.
Statistics
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PSSM-Id: 176057
View PSSM: cd08675
Aligned: 18 rows
Threshold Bit Score: 143.282
Threshold Setting Gi: 21903461
Created: 26-Mar-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
O43374       135 LRCSVLEARDLApkdrnGTSDPFVRVRYk-----gRTRETSIVKkscYPRWNETFEFElqeg----------------am 193 human
XP_415761    135 LRCTVLEARDLAkkdrnGASDPFVCVSYn-----gKTQESTVVKkscYPRWNEAFEFElpdp----------------pa 193 chicken
O95294       135 LRCHVLQARDLAprdisGTSDPFARVFWg-----sQSLETSTIKktrFPHWDEVLELRempg----------------ap 193 human
AAH80934     135 LHCHVLEARDLAprdisGTSDPFVRIFCn-----nQTLETSVIKrtrFPRWNEVLEFDlrgiee-----------ldpsd 198 western clawed ...
NP_001092921 136 LCCQVLEARDLAkkdrnGASDPFVRVRYn-----gKTYESSVVKkscYPRWNESFEFEldea---------------ltd 195 zebrafish
AAH77473      56 LLTRVLECQGLPiv--nGQCDPYATVTLlgp-srsEAKKTKVRKktnNPQFDEVFYFEvtkpcsynkkshfeieeddvdk 132 African clawed ...
CAF95517      49 LATRVLECQGLPii--nGQCDPYAAVSLlgp-srsDAKKTKVKRktnNPQFEEVFYFEvtrplsytkrq-fdveeedvdk 124 Tetraodon nigro...
EEC04328     152 LSVRVTECSDLNlv--nGSCNPYALVTLchglvkqETRKSKVRRktvCPRFEDAFYFDvrkgfnmp--------rvgacr 221 black-legged tick
CAG32764     145 LVVHIKECHGLPli-ngQNCDPYATVSLvgp-srnDQKKTKVKKktsNPQFNETFYFEvtrsssytkksqfqveeediek 222 chicken
XP_001635509 152 LSIRIIECSELFac-sgGVSDSYVSVIMi-----tPVSRSEPKKt-rVKKKTVNPQFDetflfeip--------sedles 216 starlet sea ane...
O43374       194 eALCVEAWDWDlv-srNDFLGKVVIdvqrlr-vvqqeEGWFRLQPdq------------skSRRHDEGNLGSL 252 human
XP_415761    194 eKLCVEVWDWDlv-skNDFLGKVVVsvqglq-aaghqEGWFRLQPdta-----------kpREDRRRGSLGSL 253 chicken
O95294       194 sPLRVELWDWDmv-gkNDFLGMVEFspktl--qqkppKGWFRLLPfp-------------rAEEDSGGNLGAL 250 human
AAH80934     199 qMISIEVWDWDmv-gkNDFLGRVWFpieplh-kspavTSWFRLLPfg-------------nTDEENGGKLGSL 256 western clawed frog
NP_001092921 196 sLLSVEVWDWDlv-srNDFLGKVLFninklq-salqeEGWFRLGPdk-------------sKHSEYEGTLGSL 253 zebrafish
AAH77473     133 lEIRVDLWNASnlkfgDEFLGELKLplkvlr-qsschGAWYFLQPrd-------------nGKSVKPDDLGSL 191 African clawed frog
CAF95517     125 lTLRVDLWNASnlkfgDEFLGGVRVplrvlg-qagvhDAWYFLQPrd------------ngGKSVKVEELGSL 184 Tetraodon nigroviridis
EEC04328     222 vCLQHDLSGVGgm-fgSAFLGEVRIplreldlergshQAWYLLQPrdqtqqqtqqqtqqaqQTQATTSPLGSL 293 black-legged tick
CAG32764     223 lEVRVDLWNNGnl-vqDIFLGEIKVpvkvl--rndsfQAWYLLQPre------------ngNKSSKTDDLGSL 280 chicken
XP_001635509 217 rVLRCAVWSPSml-geDIFLGEVRIplnkcd-lsivhEGWYWLGPree-----------rdSPAQRQGSIGSL 276 starlet sea anemone
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