Conserved Protein Domain Family
APC10-CUL7

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cd08665: APC10-CUL7 
APC10-like DOC1 domain of CUL7, subunit of the SCF-ROC1-like E3 ubiquitin ligase complex that mediates substrate ubiquitination.
This model represents the APC10/DOC1 domain present in CUL7, a subunit of the SCF-ROC1-like E3 Ubiquitin (Ub) ligase complex, which mediates substrate ubiquitination (or ubiquitylation), and is a component of the ubiquitin-26S proteasome pathway for selective proteolytic degradation. CUL7 is a member of the Cullin-RING ligase family and functions as a molecular scaffold assembling the SCF-ROC1-like E3 Ub ligase complex consisting of the adapter protein Skp1, CUL7, the WD40 repeat-containing F-box Fbw8 (also known as Fbx29), and ROC1 (RING-box protein 1). CUL7 is a large protein with a C-terminal cullin domain that binds ROC1 and additional domains, including an APC10/DOC1 domain. While the Fbw8 protein is responsible for substrate protein recognition, the ROC1 RING domain recruits an Ub-charged E2 Ub-conjugating enzyme for substrate ubiquitination. It remains to be determined how CUL7 binds to the Skp1-Fbw8 heterodimer. The CUL7 E3 Ub ligase has been implicated in the proteasomal degradation of the cellular proteins, cyclin D1, an important regulator of the G1 to S-phase cell cycle progression, and insulin receptor substrate 1, a critical component of the signaling pathways downstream of the insulin and insulin-like growth factor 1 receptor. CUL7 appears to be an important regulator of placental development. Germ line mutations of CUL7 are linked to 3-M syndrome and Yakuts short stature syndrome.
Statistics
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PSSM-Id: 176486
View PSSM: cd08665
Aligned: 4 rows
Threshold Bit Score: 290.288
Threshold Setting Gi: 187608207
Created: 4-Mar-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative ligand
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence homology to the protein structure of APC10 subunit of the human anaphase-promoting complex.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                   #                           #     # #                 
AAH33647      838 DKCWEKVEVSSNPHRASKLTDHnPKTYWESNGsAGSHYITLHMRRGILIRQLTLLVAseDSSYMPARVVVCGGdstSSLH 917  human
NP_001120525 1145 DKCWEKIEVSSNPHRANKLTDGnPKSYWESNGsTGSHYINIFMHRGVVARQLYMLVAseDSSYMPARLVVMGGenaSCIT 1224 western clawe...
XP_419326     540 DKCWEKVQVSSNPHRASKLTDRnPKTYWESNGsTGSHYITIHMQCGVVVREMSMLVAseDSSYMPARVVVLGGdspADVR 619  chicken
CAG05108     1224 DKCWEKVDVSSNHHRANKLTDKnPKTYWESNGcTGSHFINIYMHKGVVIRQLAILVAseDSSYMPARILVLGGddpSNIN 1303 spotted green...
Feature 1                                                   #        
AAH33647      918 TELNSVNVMPsaSRVILLENLTrFWPIIQIRIKRCQQGGIDTRIRGLEILG 968  human
NP_001120525 1225 TELNAVNISStaGRVLLLENVTrFWPIIQIKIKRCQQGGIDTRVRGLEILG 1275 western clawed frog
XP_419326     620 TELNAVTVLPsaSRVVLLENMTrFWPVIQIRVKRCQQGGIDTRVRGIEVLG 670  chicken
CAG05108     1304 TELNTVNVSPtaSRVVLLENMTrFWSIIQIRVKRCQQGGIDTRVHGFEVLG 1354 spotted green pufferfish

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