1HI9,1HI9


Conserved Protein Domain Family
DAP_dppA_1

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cd08663: DAP_dppA_1 
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Peptidase M55, D-aminopeptidase dipeptide-binding protein family
M55 Peptidase, D-Aminopeptidase dipeptide-binding protein (dppA; DAP dppA; EC 3.4.11.-) domain: Peptide transport systems are found in many bacterial species and generally function to accumulate intact peptides in the cell, where they are hydrolyzed. The dipeptide-binding protein (dppA) of Bacillus subtilis belongs to the dipeptide ABC transport (dpp) operon expressed early during sporulation. It is a binuclear zinc-dependent, D-specific aminopeptidase. The biologically active enzyme is a homodecamer with active sites buried in its channel. These self-compartmentalizing proteases are characterized by a SXDXEG motif. D-Ala-D-Ala and D-Ala-Gly-Gly are the preferred substrates. Bacillus subtilis dppA is thought to function as an adaptation to nutrient deficiency; hydrolysis of its substrate releases D-Ala which can be used subsequently as metabolic fuel. This family also contains a number of uncharacterized putative peptidases.
Statistics
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PSSM-Id: 176450
View PSSM: cd08663
Aligned: 46 rows
Threshold Bit Score: 250.159
Threshold Setting Gi: 299124741
Created: 17-Nov-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:metal binding site [ion binding site]
Evidence:
  • Structure:1HI9: Bacillus subtilis D-Aminopeptidase DppA binds two Zn(II) ions; contacts at 4.0A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               # #                                                            #         
1HI9_A         1 MKLYMSVDMEGisGLPDDtfv---------dsGKRN-YERGRLIMTEEANYCIAEAFNsg-cTEVLVNDSHSkm-----n 64  Bacillus subtilis
YP_003318454   1 MRVLISADMEGtaGVAIWeqvtpp--dlarrpAPAE-YEWARTLMVNEVNAAIQGARAag-aTEVIVNDSHDgm-----r 71  Sphaerobacter t...
YP_003321524   1 MKIVISADMEGttGVVEGihvrppdqanpagsSAAE-YGWARLTMTREVNAAIEGALEag-aEQVIVNESHDgm-----r 73  Sphaerobacter t...
ZP_05480339    1 MRILISADMEGatGVTWTddv---------vpGSPQ-WQRFRGMFTGDVNAVLAGLYAag-aTDVLVNEAHSsq-----r 64  Streptomyces sp...
Q9RTC2         1 MKVVISVDMEGvcGVASWvqvspp--efgglvNGAE-YEKARVQMTREAAAAAEGAFAag-aSDVLVNDSHDtm-----r 71  Deinococcus rad...
YP_003392828   1 MNVLISADMEGvtGVTAPedv---------hpGTAA-WERFRRLFVRDVNAAIAGACDaaddAQVIVTEGHNtm-----r 65  Conexibacter wo...
YP_003482098   1 MDVFVSADMEGvtGVADPidv---------vqDETA-YSDAQSLFVDDVNAAIEGALEgg-aDSVLVNDAHAtm-----t 64  Natrialba magad...
Q82LW0         1 MKILISADMEGatGVTWPadv---------lpGTPQ-WERCRSMFTSDVNAAVLGFFDgg-aDDVLINEAHWsm-----r 64  Streptomyces av...
ZP_03629421    1 MRVLIMTDMEGvsGIVVWeq----------veGGKPlYEECRRLYTEEINAAVRGAKAag-aTEIVVVDCHGagggwtfn 69  bacterium Ellin514
YP_003343518   1 MKVYVSVDMEGvtGLTDPeem---------haGGRG-YERGCELMTGDANAVIQGAFDag-aEAVRVNDAHGsv-----k 64  Streptosporangi...
Feature 1                                                #                              #        
1HI9_A        65 NLMVEKLHpeADLISGDVKPFSMVegl-ddtFRGALFLGYHARast-pgvMSHSMIfg-vrHFYINDrpvGELGLNAYVA 141 Bacillus subtilis
YP_003318454  72 NLRPGDLSpdAWLISGNRKPFGMMcgi-dqgIDAVMFTGYHARagtpngvLAHTWTlw-vrDVRFGDtpvGEYGLNAAVA 149 Sphaerobacter t...
YP_003321524  74 NLLPEELHreALLISGAHKPLSMAqgvdepgVAGLIYTGYHAKagtpngvLAHTYVgf-irDVRLNGvsvGEYGINAAVA 152 Sphaerobacter t...
ZP_05480339   65 NLLLEDLDerARMLTGRHKPLSMMqgi-dsgVDGVVFLGYHAGagf-dgvLSHTYLenqitGVWLDDvpaSEGRLNAAMA 142 Streptomyces sp...
Q9RTC2        72 NLLPELLPerVRYTTGNDKPLSMVqgvqeegVGALLLVGSHARagsmrgpLAHTWNgf-irNVRIGGvdtGEYGLNALLA 150 Deinococcus rad...
YP_003392828  66 NLLIEELDerAQLIVGHHTTYVMMegi-drgIDLVFLVGYHAPaga-vgvLSHTFLgkgllDLTLNDetcSEGRMNAMLA 143 Conexibacter wo...
YP_003482098  65 NLPRASLHeeATLIRGNTKPRSMMqgc-ssdHDLALFVGYHAKagtagavLNHTFMghelvRLRVNGrevGELGWNACFA 143 Natrialba magad...
Q82LW0        65 NLLLERLDerAEMLTGRHKSLSMVegvqhgdVDGIAFIGYHAGagm-egvLAHTYLansitGVWVNDeraSEGLLNSHVV 143 Streptomyces av...
ZP_03629421   70 SLVPELLDpaCEWVNHHPWGRYTElle--kgCDAALFVGMHARagtpdgvLCHTISsttwrNLYFNDfpvGETGINAAVC 147 bacterium Ellin514
YP_003343518  65 NLRIDLLDerATLIRGPGKPLRMGqgl-dpsYRAACFAGYHARagvqhgvLNHTWMgkeiqNVYLNGevcGETRLVASFA 143 Streptosporangi...
Feature 1                                                                                        
1HI9_A       142 GyyDVPVLMVAGDDRAAKEAEE-LIPnVTTAAVKQTISRsAVKCLSPAKRGRLLTEKTAFALQnkdkVKPLTPpd-rpVL 219 Bacillus subtilis
YP_003318454 150 GhfGVPVVMVAGDEMAVRQTQElLGDeVVGVIVKYGVGTtSARHMHPSRACQAIAEGAAEGLRrkdrIRPYTPny-plPV 228 Sphaerobacter t...
YP_003321524 153 GhfGVPVIMVTGDDHTVRQTQElLGErVVGVIVKRGIGTnSAIHLHPAKARDLIREGAAEAVRripeLKPYNPgw-pcRV 231 Sphaerobacter t...
ZP_05480339  143 GeyGVPVLLVSGDDQTCEDARD-YAPdAELVQVKECVSRyAAICLPPARTAQLLETGAREAMGra-gRTERTPgr--hRI 218 Streptomyces sp...
Q9RTC2       151 GhyGVPVAFASGDDVAMGEIRAeLGEgVETVAVKEGLSSfAAIHLHPAEAVRRIRAGAEAGVRraasLAPYTTrw-paPC 229 Deinococcus rad...
YP_003392828 144 GsfGVGVGLLTGDQAACADATR-YIPgVRTVAVKEQIDRySALCLPPAKTEAAIRAAAAAAVEdataHRPLVAdp-pyRW 221 Conexibacter wo...
YP_003482098 144 GslDIPVGLVTGDDATAAEAREeVGEaAETVIVKEGIDRfTANCRSPDETRPDIRTAACRAVEna-dAMPVSRpdtpvTI 222 Natrialba magad...
Q82LW0       144 AeyGVPVVLVTGDDVACEDALG-YAPeALKVAVKDHVSRyAAVCRTPSRTAADIRAAAKEAASlavpHEPVVGgp--fTV 220 Streptomyces av...
ZP_03629421  148 GhyNCPVLLVTGDEATCREAKElLGEgVTTVAVKKGLSRfSARNIPPVRARQMIEDGAREALKnlkaVKPYKPks-pcTI 226 bacterium Ellin514
YP_003343518 144 GslGVPVALVTGDEAVCEEARElLGD-VETVAVKKGVDRfSAELLPPAVAQARIREAAARALNrvadFRPCAPep-pfTL 221 Streptosporangi...
Feature 1                                                      
1HI9_A       220 SIEFaNYGQAEWANLmPGTEIKTGttTVQFQAKDMlEAYQAMLVMT 265 Bacillus subtilis
YP_003318454 229 TITLdNAEAVDLALLvPGTERVGDt-SLQYIAEDGvDLIRRWQLII 273 Sphaerobacter thermophilus DSM 20745
YP_003321524 232 EVDVdHQVQADLATIvPGVARNGEr-GFVFTAEDGvQLVTIWRAVL 276 Sphaerobacter thermophilus DSM 20745
ZP_05480339  219 EVEFdASHLAQATAViPTVEQTGTr-RVAFEAPSMtEAMKAFKVVT 263 Streptomyces sp. AA4
Q9RTC2       230 QLSFdHQARADACERvPGVTRVDAv-TVGWESENAyHLFQTFRLLA 274 Deinococcus radiodurans
YP_003392828 222 SATFaNPSSAGRAALvPGVERVEAg-TVTWSSDDFaTSYKTFQVVA 266 Conexibacter woesei DSM 14684
YP_003482098 223 SADWsATNHAAGAGRtPGVERVDDr-TTTVEAERYvDAYEATVAML 267 Natrialba magadii ATCC 43099
Q82LW0       221 ALEFdAEHLAMAATVvPGVGRIGEr-KVSYTSGTMyEGIRTFKAVT 265 Streptomyces avermitilis
ZP_03629421  227 TIDLpTVDRAGEFRGrHGVTIPDPl-KVVSKGKNWmEAWNQIWHWR 271 bacterium Ellin514
YP_003343518 222 GVEWnSTAIAAGCALiPGVRSAGPr-HTEFVTDDFsQIMALMGIFS 266 Streptosporangium roseum DSM 43021

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