Conserved Protein Domain Family
GDPD_GDE5_like_1_plant

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cd08605: GDPD_GDE5_like_1_plant 
Glycerophosphodiester phosphodiesterase domain of uncharacterized plant glycerophosphodiester phosphodiesterase-like proteins similar to mammalian GDE5
This subfamily corresponds to the glycerophosphodiester phosphodiesterase domain (GDPD) present in a group of uncharacterized plant glycerophosphodiester phosphodiesterase (GP-PDE)-like proteins. Members in this family show very high sequence homology to mammalian glycerophosphodiester phosphodiesterase GDE5 and are distantly related to plant GP-PDEs.
Statistics
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PSSM-Id: 176547
View PSSM: cd08605
Aligned: 7 rows
Threshold Bit Score: 410.264
Threshold Setting Gi: 159470395
Created: 12-Jan-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:catalytic site [active site]
Evidence:
  • Comment:The catalytic mechanism of glycerophosphodiester phosphodiesterases is based on the metal ion-dependent general acid-base reaction.
  • Comment:Based on structure evidence and site-directed mutagenesis of Thermoanaerobacter tengcongensis glycerophosphodiester phosphodiesterase, the catalytic site consists of two conserved histidine residues which serve as general acid and general base in catalyzing the hydrolysis of the 3'-5' phosphodiester bond.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1            #                                                         #                 
Q3E7S9        23 SVIGHRGIGMNvlqss-----drrarGVKENSILSFNSAAKYPIDFIEFDVQVTKDDCPVIFHDDFIyseen-givneSR 96  thale cress
CAL50333     338 AVIGHRGLQANrqs----------gaGIRENTLASFIAASQGGAEWCEFDVQVTADGVPVAWHDDIViirrgngplesFS 407 Ostreococcus tauri
XP_001693345  75 LLGGHRGMGENlashdvdgqplsvypAYRENTIESFQQAAKCGVGFVEFDVQVTRDNVPIIWHDDDVvfgaa-dapqrPM 153 Chlamydomonas r...
XP_001780869   3 VVVGHRGCGKNkvlpqgs--tpetrlSIRENTITSFNLASKNEADFVEFDVQVTKDGIPIIFHDDVIvaed----qipRH 76  Physcomitrella ...
XP_001768871  11 IVIGHRGNGKNrtllqge--ipderpSFRENTINSFNTASKFGASFVEFDVQVTRDGHPIIFHDDYIiledk--vlptTK 86  Physcomitrella ...
XP_002501246  76 AVVAHRGLGMNlkp----------gkGIRENTVASIIAAHDFGADWSEFDVQVTKDGVPVLWHDDFIsvrrgdgevenSA 145 Micromonas sp. ...
EEH54903      79 AVIGHRGDGMNrcs----------gsGIRENTVASFIAARDAGASWVEFDVQVTRDGVPVLWHDDVMlvkrgvgevesHR 148 Micromonas pusi...
Feature 1                                                                                        
Q3E7S9        97 VTDLSLSEFLLYgpqketekigkt-------------------------------------------------------- 120 thale cress
CAL50333     408 IREIDWAELRELsasarsnasrpvdalavenaiasteded---------------------------------------- 447 Ostreococcus tauri
XP_001693345 154 VKDLTLAELQALcgrggntststaatasataaghgtgaadlpssdshfqqphvlrgtsedgsvvstprggsddgsgsmvd 233 Chlamydomonas r...
XP_001780869  77 IREITLEEFRGMgpqtestkvsks-------------------------------------------------------- 100 Physcomitrella ...
XP_001768871  87 IGELSLEEFLACgpqkdkstdgrt-------------------------------------------------------- 110 Physcomitrella ...
XP_002501246 146 IRDLTIEQLKKLvrpiteteepvvi------------------------------------------------------- 170 Micromonas sp. ...
EEH54903     149 IRDLTLAEIKALsrdamataartreeeanrnimpdrcsgsenrsqple----------------------------rsss 200 Micromonas pusi...
Feature 1                                                                                        
Q3E7S9       121 -------------------lmrkskegkvlkWDVDLDDsLCTLQEAFEQVEqTLGFNIELKFDDqt------vyEREFLV 175 thale cress
CAL50333     448 ----ydddyeddessrvtfyrvfgedpepqpWIMEIEDdIPTLGQILSNTPdSLGFNIELKYDEen------scETRRLV 517 Ostreococcus tauri
XP_001693345 234 dcgatggrphskllrlfrdrstrqagtryepWACAADDsIPTLEAVFRAMPpEIGFDIEMTTGDdvv-----htPAEEVD 308 Chlamydomonas r...
XP_001780869 101 -------------------lyrkavdgsialWTTDVEDsMCILAEAFAEVQpSTGFNIELKFGDdg------stTVEELH 155 Physcomitrella ...
XP_001768871 111 -------------------lyrkakdnyvsiWTATVEDsLCTLQEVFEEVDqNVGFNVEVKFDDvl------ktSDDELR 165 Physcomitrella ...
XP_002501246 171 -------------------yrkfagtpepapWIMDVEDeIPTLDELMSVAPdDLGFSLELKFGTpedfpggkkvDPARMI 231 Micromonas sp. ...
EEH54903     201 teyseisqthvvfyrrfpvgygsvrapepepWVMDIEGpITTLEELFNDAPkSLGFSAELKFNAsn------paDEETMR 274 Micromonas pusi...
Feature 1                                                                                        
Q3E7S9       176 HILRSVLQVVSnyakdRPVIFSSFQPDAAKLVRELQSTYPVFFLTDAGneiHNDERRNSLEEAIQVClEGGLQGIVSEVK 255 thale cress
CAL50333     518 AELRAILAVCFeh-pnRRIVFSSFDPDAALLMRAIQGAYPVMILTDGEp-dHVDPRRRSVAAAMEVAlQGGLCGVVSDVK 595 Ostreococcus tauri
XP_001693345 309 RMLSAILPVQQqppmgRRIMFSSFDPDVCVELRRRQSRYPVYYLSGCGlytHADARRTSIPAALSFAvEAGMRGVVMPAS 388 Chlamydomonas r...
XP_001780869 156 RVIDAVLQDVRqlangRMIYFSSFHPDAVQILRKKMSLYPVFFLTNGGsqtYNDPRRNSIEAAIEVCrEGNLQGIVSEVK 235 Physcomitrella ...
XP_001768871 166 RVLYPILEVVKqhakgRKVYYSSFNPDAVYLLRKEQSSYPVFFLTDGGvnlFNDPRRNSIQAAVQVCeEGNLQGIVTEVG 245 Physcomitrella ...
XP_002501246 232 MELRATLAVCKsh-prRRVAFSTFDPDAATHMRALQGLYPVMFITNCQp-gQDDVRRCSVEAGIKTAlDADLVGLVIRAD 309 Micromonas sp. ...
EEH54903     275 GDLGAILAVCRah-ptRRMMFSSFDPDAACIMREMQDHYPVMMLSDCDa-gATDPRRRSVAAAVDVAlDNRLSGLVLNVN 352 Micromonas pusi...
Feature 1                                                                  
Q3E7S9       256 GVFr-------NPAAISKIKE---SNLSLLTYGklNNVGEAVYMQYVMGIDGVIVDFV 303 thale cress
CAL50333     596 AIMa-------NPSDALDVRD---NGLLLATYGegNDDATSSSTQVELGVYGIITDRV 643 Ostreococcus tauri
XP_001693345 389 VLLk-------NMDTVASAGA---SRLELMTYGleNNDLGALQAQADAGVVAAIVDEV 436 Chlamydomonas reinhardtii
XP_001780869 236 AVLq-------HPASVALVKS---QGLFFFTYGelNNFGEAVLKQKSWGIDGVIVDHV 283 Physcomitrella patens subsp. patens
XP_001768871 246 AILr-------EPTLVSLVKQ---VGLWLFSYGvlNNIAEVVEKQKILGVDGVIVDHV 293 Physcomitrella patens subsp. patens
XP_002501246 310 VLRn-------DPTVPTRVRA---AGLMLGSYGgpNTDLALVERQVDLGVGYLCTDDV 357 Micromonas sp. RCC299
EEH54903     353 VLSsnggnkamDPTARSIADDvrgKGLYLGTYGkaNDDAEFVVRQAEWGASYVCTDAV 410 Micromonas pusilla CCMP1545

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