Conserved Protein Domain Family
GDPD_SHV3_repeat_2

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cd08604: GDPD_SHV3_repeat_2 
Glycerophosphodiester phosphodiesterase domain repeat 2 of glycerophosphodiester phosphodiesterase-like protein SHV3 and SHV3-like proteins
This subfamily corresponds to the glycerophosphodiester phosphodiesterase domain (GDPD) repeat 2 present in glycerophosphodiester phosphodiesterase (GP-GDE)-like protein SHV3 and SHV3-like proteins (SVLs), which may play important an role in cell wall organization. The prototype of this family is a glycosylphosphatidylinositol (GPI) anchored protein SHV3 encoded by shaven3 (shv3) gene from Arabidopsis thaliana. Members in this family show sequence homology to bacterial GP-GDEs (EC 3.1.4.46) that catalyze the hydrolysis of various glycerophosphodiesters, and produce sn-glycerol-3-phosphate (G3P) and the corresponding alcohols. Both, SHV3 and SVLs, have two tandemly repeated GDPD domains whose biochemical functions remain unclear. The residues essential for interactions with the substrates and calcium ions in bacterial GP-GDEs are not conserved in SHV3 and SVLs, which suggests that the function of GDPD domains in these proteins might be distinct from those in typical bacterial GP-GDEs. In addition, the two tandem repeats show low sequence similarity to each other, suggesting they have different biochemical function. Most of the members of this family are Arabidopsis-specific gene products. To date, SHV3 orthologues are only found in Physcomitrella patens. This CD includes domain II (the second GDPD domain of SHV3 and SVLs), which is necessary for SHV3 function.
Statistics
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PSSM-Id: 176546
View PSSM: cd08604
Aligned: 14 rows
Threshold Bit Score: 420.976
Threshold Setting Gi: 168007624
Created: 15-Dec-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
NP_567755     360 FLVITKDGASGDYPGCTDLAYKKAIKDGADVIDCSVQLSSDGTPFCLSSIDLGNSTTVsl--taFRNRSTTVPELgs-lg 436  thale cress
XP_001756342  364 PLIIAQNGASGDYPGSTLSAYVAAVKGGSDYIECSVQITKDGVPICRDGANLVNTTNValnpdlFETKFTTYQEMg---s 440  Physcomitrell...
XP_001756508  357 PIIIAEDGASGDLPGSTMAAYLKAIDDGADYIECKVQITSDGVPICRDGENLLNNTNIgssqakLEKYYTAYPDFg---y 433  Physcomitrell...
EEC72640      372 PLIITHNGASGVYPGSTDLAYQQAVKDGADIIDCAVRMSKDGVAFCQPSADLSTSTTAst---sFMTKISTVSEIqn-ks 447  Indian rice
NP_200613     355 ALVITHNGASGDYPGCTDLAYQKAIDDGADIIDCSVQMSKDGIAFCHDAADLSASTTArt---tFMSRATSVPEIqp-tn 430  thale cress
NP_188688     337 ITIISKNGASGDFPGCTDLAYQRAASDGADILDCNVQMSKDKIPFCMSSFDLINSTNVie--tsFRNLSSVVSEInprrs 414  thale cress
BAE53680      356 LQIITSEGASGDYPGCTDLAYTKAASDGADVLGCPVQMTKDRVPFCLGSINLIDKTTAaq--spFSNIATTVPELki-tn 432  common tobacco
EEE53168      298 ILIISHNGASGDYPDCTDLAYEKAVGDGADVIDCSIEMTKDGIPICMSSINLYDSTDVqn--skFSSLASVVPEIqt-kp 374  Japanese rice
CAH67272      352 PLIISHNGASGDYPACTDLAYQKAVDDGADVIDCPVQLTKDGIPICMSSINLMDDTTVak--sqFASQTAVIKDIes-vl 428  Indian rice
NP_200625     355 ALVITHNGASGDYPGCTDLAYQKAVDDGADVIDCSVQMSKDGIAFCHDAADLTASTTAmt---iFMSRATSVPEIqp-tn 430  thale cress
NP_567755     437 AIYTFSLTWAEIQTLTPAISNPyrvt-slfRNPKQKNAGKLFSLSDFLSLAKnstslSGVLISVENAAYLreeQGLDVVK 515  thale cress
XP_001756342  441 GVFSFDLTLEEIRTLRGILFSPfgvv-nvsRDPSLDGKEGILTLDEFLSFAKnn-sgVGVYVNVQNAYFVrtvKSLDMVS 518  Physcomitrell...
XP_001756508  434 GVFSFDVPSTEIQNLRGIISRPnns---tsRDPANDGKESILTLKEFLNLSKiy-tnTGLYVNVQNAYKVyrlKNLDMVS 509  Physcomitrell...
EEC72640      448 GIFSFDLTWSEIQTLKPDLLGPytqa-glkRNPAAKNAGKFVTLPEFLDLAKat-nvSGIMVEMEHASFLa-kRGLGLVD 524  Indian rice
NP_200613     431 GIFSFDLTWAEIQSVKPQIENPftat-gfqRNPANKNAGKFTTLADFLELGKak-avTGVLINIQNAAYLaskKGLGVVD 508  thale cress
NP_188688     415 GIYTFSLTMSQIQTLKPTISNLekds-glfRNPRNNKAGKFLTLSEFLFLPNrysslLGLLIEVENAAYLvehQGISVVD 493  thale cress
BAE53680      433 GILTINLTWTEIQSLKPAISNRwsef-rlfRNPKARNDGNFMSLADFLTFAKnatsvSGVMISVENAAYMa-kQGLGVTG 510  common tobacco
EEE53168      375 GIFTFNLTWEEISTLRPKITHPyhd---fvRNPRYANQGKFFKLSDFLTYAKdk-dlSGIMIIMKNAAFMaksLGFDVVD 450  Japanese rice
CAH67272      429 GVFTFNLTWDDIVKNLRPKISTpfssfkldRNPRYRNAGNFMRLSDFLDFTKdk-dlSGIMISVEHAAFVaeeLGFDMVD 507  Indian rice
NP_200625     431 GIFSFDLTWAEIQSVKPQIENPftat-gfqRNPANKNAGKFITLADFLDFSKak-avTGVMINIENAAYLaskKGLGVVD 508  thale cress
NP_567755     516 AVLDTLTQTGYSNst-----atKVMIQSTNSSVLVDFKKqs---qYETVYKVEENIRDil--dsAIEDIKKFADAVVIQK 585  thale cress
XP_001756342  519 AVVTSLTTANLTNvg------dKVYLASEDSSALAAFQSli--psVQRVYVTPDTGDVtit-taVLQEIKKYADIVTLDR 589  Physcomitrell...
XP_001756508  510 AVATALAVADLTNag------dKVLLASEDTSALNAFQEvi--pnVRLVYVIANNEMDysvpreVLKEIKKYADTVHIYR 581  Physcomitrell...
EEC72640      525 AVSGALANASYDKegg---hlpELMVVSDDTSVLAAFKKfp---aFRRVLMVDETISDas--apSVEEIKQFATAVTVGR 596  Indian rice
NP_200613     509 VVKSALTNSTLDKqs-----tqKVLIQSDDSSVLSSFEAvp---pYTRVLSIDKEIGDap--ktSIEEIKKHADAVNLLR 578  thale cress
NP_188688     494 AVLDELKRATTQQnkt---sarTILIQSTDKSVLMKFKEknkmnhDELVYRVDDNIRDva--dsAIKDIKNFAGSIVISK 568  thale cress
BAE53680      511 AVLDALSKAGYNNqt-----akKVLIQSTDSSVLEEFKKs----sYELVYGVGDDIRDie--ssTILEIKTFAKSVIITK 579  common tobacco
EEE53168      451 LVTTALSNAGYDNmdpttknnkEIMIQSKDSAVLVKLKQrl--tqCKLVYSLPLKVGDvs--dsCVADIKKFADAVIVDR 526  Japanese rice
CAH67272      508 SVIKTLDAAGYSNqt-----aqKVMIQSSNSSVLVKFKQqt---kYDLVYMINEEVKDaa--psSLAAIKKFADAVSVEG 577  Indian rice
NP_200625     509 AVKSALAKSTLDKqs-----tqKVLIQSDDSSVLASFEAvp---pYTRVLSIDKEIGGap--kpSVDEIKKYAEAVNLLR 578  thale cress
NP_567755     586 LSVFPva--qsFITTQTNVVEKLQKsQLPVYVELFQNEFLSqPYDFFADATVEINSYITGa------gINGTITEFPFTA 657  thale cress
XP_001756342  590 AFVDPfdsqtsFLLEKTSVVSAAKSlNMTVFYHFLANEFSGlAFDYRADPILKISYLISEy------nLDGFITDHPATL 663  Physcomitrell...
XP_001756508  582 SFIDRidpytyFVNKMTSVVQEAKAlNMTVFYASISNEYLNlAFDYRADPHLKMYYLLQElqsngkslLDGFLTVYPATV 661  Physcomitrell...
EEC72640      597 GSIAQvn--gfFLTRFTDVADRMHAaNLTVYVGVLRNEFMNlGFDYWADPIIEIATYAFHv------mADGLITEYPATA 668  Indian rice
NP_200613     579 TSLITvs--qsFATGKTNVVEEMHKaNISVYVSVLRNEYIAiAFDYFSDPTIELATFIAGr------gVDGVITEFPATA 650  thale cress
NP_188688     569 KSVFPykg-fiILEKETNIASKLKSnGLRVYVERFSNECVThAFDFYDDPTLEIDSFVRDv------qIDGIITDFPATT 641  thale cress
BAE53680      580 QSVFPse--daFIIAQTNVVQKLQSsNLTVYVQLLNNEFVSqSWDFFSDSSVELNNYAVGa------gIDGVITEYPATA 651  common tobacco
EEE53168      527 ESVFAes--kgFIIRKSKVVEDVQSaGLAVYVEVFRNEYVSpPVDFFADGTVEINNYVQLv------hVDGFITDFPKTV 598  Japanese rice
CAH67272      578 NSIFPen--rhFTTYQTNLVESLQNaGLPVYVYTLMNEFASqPYDFFSDATAQINAYVQGa------gVNGVITDFPATA 649  Indian rice
NP_200625     579 TSLVTvs--qsFTTGKTNVVEEMHKgNISVYVSVLRNEYISvAFDYFSDPTIELATFISGs------gVDGVITEFPATA 650  thale cress
NP_567755     658 ARY 660  thale cress
XP_001756342  664 YNF 666  Physcomitrella patens subsp. patens
XP_001756508  662 YNF 664  Physcomitrella patens subsp. patens
EEC72640      669 ATY 671  Indian rice
NP_200613     651 TRY 653  thale cress
NP_188688     642 ARY 644  thale cress
BAE53680      652 ARY 654  common tobacco
EEE53168      599 RRY 601  Japanese rice
CAH67272      650 RRY 652  Indian rice
NP_200625     651 TRY 653  thale cress
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