Conserved Protein Domain Family
GDPD_SHV3_repeat_1

?
cd08603: GDPD_SHV3_repeat_1 
Glycerophosphodiester phosphodiesterase domain repeat 1 of glycerophosphodiester phosphodiesterase-like protein SHV3 and SHV3-like proteins
This subfamily corresponds to the glycerophosphodiester phosphodiesterase domain (GDPD) repeat 1 present in glycerophosphodiester phosphodiesterase (GP-GDE)-like protein SHV3 and SHV3-like proteins (SVLs), which may play an important role in cell wall organization. The prototype of this family is a glycosylphosphatidylinositol (GPI) anchored protein SHV3 encoded by shaven3 (shv3) gene from Arabidopsis thaliana. Members in this family show sequence homology to bacterial GP-GDEs (EC 3.1.4.46) that catalyze the hydrolysis of various glycerophosphodiesters, and produce sn-glycerol-3-phosphate (G3P) and the corresponding alcohols. Both, SHV3 and SVLs, have two tandemly repeated GDPD domains whose biochemical functions remain unclear. The residues essential for interactions with the substrates and calcium ions in bacterial GP-GDEs are not conserved in SHV3 and SVLs, which suggests that the function of GDPD domains in these proteins might be distinct from those in typical bacterial GP-GDEs. In addition, the two tandem repeats show low sequence similarity to each other, suggesting they have different biochemical function. Most of the members of this family are Arabidopsis-specific gene products. To date, SHV3 orthologues are only found in Physcomitrella patens. This family includes domain I, the first GDPD domain of SHV3 and SVLs.
Statistics
?
PSSM-Id: 176545
View PSSM: cd08603
Aligned: 11 rows
Threshold Bit Score: 421.024
Threshold Setting Gi: 168007624
Created: 15-Dec-2009
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Q7Y208         50 PLVIARGGFSGLYPDSSIAAYQLATLTSvadVVLWCDLQLTKDGLGICFPDLNLANASTIdrvypnreks--ysvngvtt 127  thale cress
NP_001062173   54 PIVIAEGGFSGVFPDSSKNAYVFALSSTsgdTVLWCNVQLTKDGVGICLRDLLMDNCTSIsqayragkka--ylvngeek 131  Japanese rice
NP_188688      33 PAVIARGGFSGMFPDSSIQAYQLVNITTspdVMLWCDLQLTKDGVGICFPNLKLDNGSNVirid-------------phy 99   thale cress
EEC72640       52 PLVIARGGFSGLFPDSSQFSYQFAMSSSlhdVVLYCDLQLSSDGLGFCKTGLTLENSTLIaeafpkrakt--ykvngeei 129  Indian rice
NP_200613      41 PAVVARGGFSGLFPESSISANDLAIGTSspgFTMLCNLQMTKDGVGLCLSDIRLDNATTIssvfpkaqkt--ykvngqdl 118  thale cress
XP_001756508   38 PLVIANGGTSGLYPDQTLRAYRDAANSTsspLALLCDLMISKDNFGICRPGFFLEMSTNTtsypatakrs-tysgygqnl 116  Physcomitrell...
NP_176869      50 PLVIARGGFSGLYPDSSIAAYQLATLTSvadVVLWCDLQLTKDGLGICFPDLNLANASTIdrvypnreks--ysvngvtt 127  thale cress
NP_200359      50 PLVIARGGFSGLLPDSSLDAYSFVSQTSvpgAVLWCDVQLTKDAIGLCFPDVKMMNASNIqdvypkrkts--yllngvpt 127  thale cress
ACN35879       63 PLVVARGGFSGAFPDSSEGAYSFGASASapgTAMWCDVQLTKDGVGLCLRDVNMKNCTTVdqtypgrkrt--yvidgvhk 140  maize
NP_001047275   40 PAIIAKGGFSGLFPDSSDFAYGFVAAASspdTALWCDVQLTKDGAGICLPDIRMDNCTNIanvypkgkkt--ysvngvst 117  Oryza sativa ...
EDQ78738       25 PLIVANGGTSGLYPDQTLEAYSDAINSTslpLALLCDLQLTKDNLAVCRTGLNLTTSTTLatvmpntttmttyvvrgasq 104  Physcomitrell...
Q7Y208        128 kGWFPNDFSLTELQnf-lLIRGILSRTDRFDgngylISTIEDVVTTLNr-----eGFWLNVQHDAFYeq--qNLSMSSFL 199  thale cress
NP_001062173  132 kGWFPIDYTMSSLQsv-iLTQAIWSRTDKFDfaflpILPVTNVIDLAKp-----sSVWLNIEHDIFYrq--hGLNMTKYI 203  Japanese rice
NP_188688     100 kERFSVDFTWKELSdv-kLAQGVVSRPYIFDdv-ssILAIEEVAKLTAs------GLWLNIQDSAFYak--hNLSMRNSV 169  thale cress
EEC72640      130 hGWFALDFTADELYqnvtLIQDIFSRPSTFDga-mgMFTLEDLVGLKPp------HLWVNVEYALFLqe--hKLSAEDYI 200  Indian rice
NP_200613     119 kGWFVIDYDADTIFnkvtLVQNIFSRPSIFDgq-msVSAVEDVLGTKPp------KFWLSVQYDAFYme--hKLSPAEYL 189  thale cress
XP_001756508  117 tGYFANDFTLAELLtv-tGMRTSNARPPIFTqe--tLAAPENVSQIAAef---gvATWINVEFPEFFqeypaPNSLLSYL 190  Physcomitrell...
NP_176869     128 kGWFPNDFSLTELQnf-lLIRGILSRTDRFDgngylISTIEDVVTTLNr-----eGFWLNVQHDAFYeq--qNLSMSSFL 199  thale cress
NP_200359     128 qDWFTIDFNFKDLTkv-iLKQGILSRSAAFDgnsygISTVKDISTQLKp-----eGFWLNVQHDAFYaq--hNLSMSSFL 199  thale cress
ACN35879      141 tGWFVPDFTSAELLqsvyLTQAIWSRTERMDgi-ypIVTVPDVQSIVNt-----sPIWLNVQHPIFYkq--rDLDMSSYI 212  maize
NP_001047275  118 pGWFSVDYDSTGLSkv-nLVQSLFSRVPYYDgt-lpILPVESVFANYKa-----pAVWLNVQHDSFYsq--fNLSMRSYI 188  Oryza sativa ...
EDQ78738      105 tGYFSVDFTLAEINqt-kAIQPNIARTPGFDgq-faLQTPEDSATGISlaglpglMLWLNVEYPTFYqqhpgKNSLASYL 182  Physcomitrell...
Q7Y208        200 LSVSRtvsIDFISSPEVNFFKKITgsfgrngPTFVFQFLGKEDFEpttnrtygsilsNLTFVKTFASGILVPKSYILPld 279  thale cress
NP_001062173  204 LSIPKggsVQYISSPELGFLQSISgrv-nrkTKLVFRFLDATSSDpssnqtygsllsNLTFIKTVASGIMVPKEYIWPvt 282  Japanese rice
NP_188688     170 VSLSRrlkVNFISSPGISFLKSMKnsvkptvTKLIFRFLKQEHIEpftnqsygslakNLSYIRTFSSGILVPKSYIWPvd 249  thale cress
EEC72640      201 LGLPKdfsVAYISSPEIGFLKNVGaklkksnTKLIFRFLREDVAEhttkktygeilkDLKSVKAFASGILVPKEYIWPlg 280  Indian rice
NP_200613     190 RSLRFr-gINVISSPEIGFLKSIGmdagrakTKLIFEFKDPEAVEpttnkkyseiqqNLAAIKAFASGVLVPKDYIWPid 268  thale cress
XP_001756508  191 TSFLKtnkVQYLSVTNSSILKLIApt---ngTRLVLKLLDYDGLVdpl-------fqNLTDIATYAQGVLVPNSYVIPkn 260  Physcomitrell...
NP_176869     200 LSVSRtvsIDFISSPEVNFFKKITgsfgrngPTFVFQFLGKEDFEpttnrtygsilsNLTFVKTFASGILVPKSYILPld 279  thale cress
NP_200359     200 LSISKtviIDYLSSPEVNFFRNIGrrfgrngPKFVFRFLEKDDVEvstnqtygslagNLTFLKTFASGVLVPKSYIWPie 279  thale cress
ACN35879      213 HSIRKlvrMDYISSPEIGFLRNISarv-rrrTKLVFSFLDKKLLDhsvnqtygslarNLTFVRSVASGILVPKDYIWPvt 291  maize
NP_001047275  189 LSVSKqyiADYISSPEVNFLTSLSgrv-nkkTKLVFRLLNELAVEpstnqtygsmlkNLTFIKTFASGILVPKNYIWPvt 267  Oryza sativa ...
EDQ78738      183 TTFLKqykPQYLSATEVGILKLLVptasrsaTRLVLKFLSTDLIEestnstygqiltNLTDIATFAGGILVPKEFIYPtv 262  Physcomitrell...
Q7Y208        280 d---------eqYLVPHTSLVQDAHKAGLQVYVSGFANDVd-iAYNYSSDPVSEYLSFVDNgdFSVDGVLSDFPITASAA 349  thale cress
NP_001062173  283 t---------nnYIQPAKSIVRDAHSAGLEIYASDFANDRi-iPYNYSYDPLEEYLHFVGSdnFSVDGVLSEFPLTAAAA 352  Japanese rice
NP_188688     250 s---------alYLQPHTSLVTDAHKEGLQVFASEFANDFv-iAYNYSYDPTAEYLSFIDNgnFSVDGFLSDFPVTPYRA 319  thale cress
EEC72640      281 k---------dqYLRLPTSLVKDSHALGLEVFASGFANDVs-mSYNYSFDPSAEYLQYIGNanFSVDGVITDFPPTASGA 350  Indian rice
NP_200613     269 s---------akYLKPATTFVADAHKAGLEVYASGFANDLr-tSFNYSYDPSAEYLQFVDNgqFSVDGVITDFPPTASQS 338  thale cress
XP_001756508  261 ft------gygvYEGQATTAVQDAHKAGLEIFVYGFANDRqpyIYNYSKDPVLEVLSYVGDs-FTADGIVTDFPNTAATA 333  Physcomitrell...
NP_176869     280 d---------eqYLVPHTSLVQDAHKAGLQVYVSGFANDVd-iAYNYSSDPVSEYLSFVDNgdFSVDGVLSDFPITASAA 349  thale cress
NP_200359     280 ----------sqYLLPRTSFVQDAHKAGLEVYASGFGNDFd-lAYNYSFDPLAEYLSFMDNgdFSVDGLLSDFPLTASSA 348  thale cress
ACN35879      292 a---------dnYLLPSTSIVTEAHEAGLEIYASGFVNDKa-vPFNYSYDPLAEYLNFVGDggFSVDGVLSDYPITASEA 361  maize
NP_001047275  268 q---------dnYLQPSTSVVGDAHKAGLEVYAADFANDFl-lSYNYSYDPLTEYLNFIDNgaFSVDGVLTDFPITPSEA 337  Oryza sativa ...
EDQ78738      263 plsngsvsgygyYSGNPTTLVQDAHNANLEVFVYGFANDIypsSYNNSFDPVLESLNYVGDs-FTVDGIVSDFPSTVAEA 341  Physcomitrell...
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap