Conserved Protein Domain Family
GDPD_ScGlpQ1_like

?
cd08602: GDPD_ScGlpQ1_like 
Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins
This subfamily corresponds to the glycerophosphodiester phosphodiesterase domain (GDPD) present in a group of putative bacterial and eukaryotic glycerophosphodiester phosphodiesterases (GP-GDE, EC 3.1.4.46) similar to Escherichia coli periplasmic phosphodiesterase GlpQ, as well as plant glycerophosphodiester phosphodiesterases (GP-PDEs), all of which catalyzes the Ca2+-dependent degradation of periplasmic glycerophosphodiesters to produce sn-glycerol-3-phosphate (G3P) and the corresponding alcohols. The prototypes of this family include putative secreted phosphodiesterase encoded by gene glpQ1 (SCO1565) from the pho regulon in Streptomyces coelicolor genome, and in plants, two distinct Arabidopsis thaliana genes, AT5G08030 and AT1G74210, coding putative GP-PDEs from the cell walls and vacuoles, respectively.
Statistics
?
PSSM-Id: 176544
View PSSM: cd08602
Aligned: 19 rows
Threshold Bit Score: 406.299
Threshold Setting Gi: 225710416
Created: 13-Jan-2010
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
 
Feature 1:catalytic site [active site]
Evidence:
  • Comment:The catalytic mechanism of glycerophosphodiester phosphodiesterases is based on the metal ion-dependent general acid-base reaction.
  • Comment:Based on structure evidence and site-directed mutagenesis of Thermoanaerobacter tengcongensis glycerophosphodiester phosphodiesterase, the catalytic site consists of two conserved histidine residues which serve as general acid and general base in catalyzing the hydrolysis of the 3'-5' phosphodiester bond.

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1             #                                          #                               
NP_733538     59 PTVIGHRGASGYrPEHTFGSYELALDLGADIVEAgDLVPTKDGHLVCRHEPEIGGTTDVAd---------HREFADRkrt 129 Streptomyces co...
ACO11054      29 PLNLAHRGSSGMfPEHTRKAYVSALEQGADYIEC-DVVITSDLQLICSHEPWISETSNVAdhsgsisgvpHTDFSDRlqt 107 Caligus rogercr...
XP_002130894  37 PLNIAHRGSSGMrPEHTVAAYQLAVDQGADIIEC-DLAVTKDLKFICTHDSWLNATTDVSs---------HKEFDDRvnt 106 Ciona intestinalis
CBA33326      57 PLVIGHRGASGYlPEHTLASYKKAIEMGADFIEP-DLVVTKDGELVARHEPNITATTDVSt---------RAEFASRktt 126 Curvibacter put...
EEY62069      58 PTITGHRGAPGYlPDHTIEGYTLAIETGVDVIEP-DLVSTKDGVLVVRHEPYIDGTTNVAd---------HPEFADRltt 127 Phytophthora in...
ZP_01051355    6 PIIIAHRGAQSIyPEHTMQGYKKAVQLGADYIEP-DLVMTKDGVLIARHEPFISTTTNVSt---------LPQYANRktt 75  Dokdonia dongha...
XP_001692079  13 PYVVGHRGACGYrPDHTMASYQLAVDMGADFIEC-DVVLTKDLVPVCRHEPLLSDTTDADa---------KVRTFPSlik 82  Chlamydomonas r...
NP_196420     44 PYNLAHRGSNGElPEETAPAYMRAIEEGADFIET-DILSSKDGVLICHHDVNLDDTTDVAd---------HKEFADRkrt 113 thale cress
NP_177561     44 PYNIAHRGSNGEiPEETTAAYLKAIEEGTDFIET-DILSSKDGVLICFHDCILDETTNVAs---------HKEFADRkrt 113 thale cress
ABR16222      49 PYNIAHRGSNGEiPEETAAAYMRAIEEGADFIET-DILATKDGALICFHDVTLDDTTDVHk---------HKEFSDRrrt 118 Sitka spruce
Feature 1                                                                                        
NP_733538    130 ----------klLDGVSTTGWFTEDFTLAELKTLRAtERIPANRPhntlYDGRWEIPTFEEVLRWQNeqtrrrgkqVWIY 199 Streptomyces co...
ACO11054     108 ydmndddpdfdwNDKGMVTDYFSFDFTLEEIMELRRkQVKPNRDPq---FDWQYGFVTFDEFVEIAKsy------gAGIY 178 Caligus rogercr...
XP_002130894 107 ----------yrIDGILRRDYFTIDFTLEELKTLKTiQSRSYRDQs---YNGMYPMASFDEYVAVAKnata-ngrtVGIY 172 Ciona intestinalis
CBA33326     127 ----------rkVDGVNETGWFVTDFTLAELRTLRAkQPNAARDKs---FDGQFQIPTFREILELAKtesartgrtIGVY 193 Curvibacter put...
EEY62069     128 ----------ktVDGMPILGYFVSDFTLAEIKTLRTvQPLPERDQs---FDGLYEIPTFEEVIQLAQnksaeynrtIAIY 194 Phytophthora in...
ZP_01051355   76 ----------klLDGVAVTDWFVSDFTIGELKTLRArQSWANRTHe---YDDLFEIPTFEEILAFAKahkttagnpVGVY 142 Dokdonia dongha...
XP_001692079  83 ---------tntIDGYNYTGVFANDLTLAELKTLRArQPLPERDQs---FNGLYPVPTLEEYIALAKaap----rtVGIY 146 Chlamydomonas r...
NP_196420    114 ----------yeVQGMNMTGFFTVDFTLKELKTLGAkQRYPFRDQq---YNGKFPIITFDEYISIALdap----rvVGIY 176 thale cress
NP_177561    114 ----------ydVQGFNITGFFTFDFTLKELKQLRIkQRYAFRDQq---YNGMYPIITFEEFLTIARdap----rvVGIY 176 thale cress
ABR16222     119 ----------yeVQGTNVTGWFTVDFTLDEIMTLRVkQRYEYRDQs---YNWKFSIITFKEYIDIALdap----rvVGIY 181 Sitka spruce
Feature 1                                                                                        
NP_733538    200 PELKHPTYFrk------lGLGTEERLARLLRKYGKdr-------knSPVIIQSFEPTSIQRMNKLvgNPLAVLLSGansr 266 Streptomyces co...
ACO11054     179 PEIKQPTAInrilsergiEDPIEDIILRKLSEHGMdk-------edSKVFLQCFELSTIKNLREKtdLPRIFLVKRep-- 249 Caligus rogercr...
XP_002130894 173 PETKNPPFFnqhl--ldkNTTMEDLLLTSLEKHGYvt-------ptSPCFIQSFEPNSLRYLANKtgLPLIFLVNVp--- 240 Ciona intestinalis
CBA33326     194 PETKHPTYHvd------aGLPIEPRLLAMLAEYGYtk-------kdSPVIIQSFEVSNLKALRKLtqVRLVQLVDAddvd 260 Curvibacter put...
EEY62069     195 PEVKHSSFHka------lGLPIENTMLELLTKYGWnh-------adAPVFIQSFETANLRELNEItnLTLVQLIDGfgnd 261 Phytophthora in...
ZP_01051355  143 PELKHPTYHka------lGLPMEDHFLKMINAAGYns-------keSSIYVQCFEVATLQYLRSKsdVKLIQLLGAagit 209 Dokdonia dongha...
XP_001692079 147 PETKHPTWHdslpivkaaQTTMSDIVLDVLEKHGYkgpvnskawsrQPAFIQSFEVGNLKYLSRKtcIPLVQLMDDftaa 226 Chlamydomonas r...
NP_196420    177 PEIKNPVFMnqqv-kwadGKKFEDKFVETLKKYGYkgsylsedwlkQPIFIQSFAATSLVYISNMtdSPKLFLIDDvtil 255 thale cress
NP_177561    177 PEIKNPVLMnqhv-kwpgGKKFEDKVVETLKKYGYggsylskkwlkKPLFIQSFAPTSLVYISNLtdSPKVLLIDDvtmp 255 thale cress
ABR16222     182 PEMKNPVFInqhv-kwpgGKRFEDKFMETLLSYGYkgeylssdwlkQPIFIQSFAPTSLVYVSNFtdSPKILLIDDvtvp 260 Sitka spruce
Feature 1                                                                                        
NP_733538    267 pwdfvet-------------------gdprttadlvTPEGLKEIAS-YAQGIGPTLDLIVpkdsag-------------- 312 Streptomyces co...
ACO11054     250 ----------------------------------kfTEALWEELADsGIVGIGAPKSLIIktesveeadp---------- 285 Caligus rogercr...
XP_002130894 241 -----------------------------------iTDAKLTEFAQ-FCYGLGPSKSLILptvnd--------------- 269 Ciona intestinalis
CBA33326     261 skgnvtlvapfdk------pydfaiakdsrtfpdllTPKGLAEVKT-YADGIGPWKPYLAsaahvmgadgkprdln-gdg 332 Curvibacter put...
EEY62069     262 pltgevlfqapsdr-----pydwtlanrtdyfgyltTPAGLAEITT-YADIISPWKRYLLksiavkadanggvvdsngdg 335 Phytophthora in...
ZP_01051355  210 ndgnllftkengsydpegqpydfiknkdkrsyqfftTKEGMEFMAT-YADAVGPWKPFIIsvnsng-------------- 274 Dokdonia dongha...
XP_001692079 227 ipdmp-----------------------tktysdlmTDAAMKDIAT-YASGVGPWKNTLTanga---------------- 266 Chlamydomonas r...
NP_196420    256 tedt------------------------nktyaeitSDAYLDYIKP-YVIGIGPWKDTIVpvnnn--------------- 295 thale cress
NP_177561    256 tqdt------------------------nqtyaeitSDAYFEYIKQ-YVVGIGPWKDTIVpvnnn--------------- 295 thale cress
ABR16222     261 tqdt------------------------dqsyweitSDKYFDFIKK-YVVGIGPWKDTIVppdsrn-------------- 301 Sitka spruce
Feature 1                                                                                   
NP_733538    313 -------rltepTTLVRDAHRAGLILHPYTMRNENpflpaefrqgsdpdaYGDVFGAFRTYFa-tGIDGVFTDNP 379 Streptomyces coelico...
ACO11054     286 --qdpgsitlidHQRINTIHSYGLMVHLYTFRNEWtdip--------wdfGKDPFKEYEEYTr-iGIDGFFTDFP 349 Caligus rogercresseyi
XP_002130894 270 -------rlgqsTDFISRAHANGFKIHPYTFRNEDqfla--------tdyASDPYEEYNTFVe-lGVDGLFTDFP 328 Ciona intestinalis
CBA33326     333 kitdadrvalppTDVVKNAHAAGLFVHAYTFRSEApgll--------sdyKGDPKAEYKRFYa-lGVDGLFSDFP 398 Curvibacter putative...
EEY62069     336 rvtdadyaivefPNIIEDAHAAGLKVHTWTMRDENyrla--------anySGNATLEYLALFd-mGIDGVFSDNC 401 Phytophthora infesta...
ZP_01051355  275 -------vltpvTNFVALAHSHNLEVHPYTFRNEDtkw----------vtDTNHIDEYLRFFe-aGVDGVFSDYT 331 Dokdonia donghaensis...
XP_001692079 267 --------glesTGLVERIHKYGMQLHPYTFRDEAyrlt--------ygsFSTPWDEYELFFdkmGIDGAFTDSA 325 Chlamydomonas reinha...
NP_196420    296 -------rlmtpTDLVARAHSRNLQVHPYTYRNENqflh--------lefNQDPYLEYDYWLnkiGVDGLFTDFT 355 thale cress
NP_177561    296 -------yvlapTDLVKRAHAHNLQVHPYTYRNEHeflh--------ynfSQDPYKEYDYWIneiGVDGLFTDFT 355 thale cress
ABR16222     302 -------ylttpTDLVAKAHAHDLQVHPYTYRNENvflh--------fnfHEDPYAEYEYWIkviGVDGLFTDFT 361 Sitka spruce

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap