Conserved Protein Domain Family
PI-PLCc_PRIP_metazoa

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cd08597: PI-PLCc_PRIP_metazoa 
Catalytic domain of metazoan phospholipase C related, but catalytically inactive protein
This family corresponds to the catalytic domain present in metazoan phospholipase C related, but catalytically inactive proteins (PRIP), which belong to a group of novel Inositol 1,4,5-trisphosphate (InsP3) binding protein. PRIP has a primary structure and domain architecture, incorporating a pleckstrin homology (PH) domain, an array of EF hands, a PLC catalytic core domain with highly conserved X- and Y-regions split by a linker sequence, and a C-terminal C2 domain, similar to phosphoinositide-specific phospholipases C (PI-PLC, EC 3.1.4.11)-delta isoforms. Due to replacement of critical catalytic residues, PRIP do not have PLC enzymatic activity. PRIP consists of two subfamilies, PRIP-1(previously known as p130 or PLC-1), which is predominantly expressed in the brain, and PRIP-2 (previously known as PLC-2), which exhibits a relatively ubiquitous expression. Experiments show both, PRIP-1 and PRIP-2, are involved in InsP3-mediated calcium signaling pathway and GABA(A)receptor-mediated signaling pathway. In addition, PRIP-2 acts as a negative regulator of B-cell receptor signaling and immune responses.
Statistics
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PSSM-Id: 176539
View PSSM: cd08597
Aligned: 9 rows
Threshold Bit Score: 442.63
Threshold Setting Gi: 229279905
Created: 2-Oct-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9UPR0        425 CQDMKQPLSHYFINSSHNTYLIEDQFRGPSDiTGYIRALKMGCRSVELDVWDGPDn--EPVIYTGHTMTSQIVFRSVIDI 502  human
CAG11094      346 CQDMSQPLSHYYICSSHNTYLIEDQIRGPSDiSGYIRALKMGCRCVEVDVWDGSDg--EPVVCTGHTLSPPLALHSVLEA 423  spotted green...
XP_421916     328 VQDMTQPLSHYYINASHNTYLIEDQLRGPADiNGYVRALKMSCRSIELDVCDGPDn--EPIICNRNNMTSPLSFQNVIEV 405  chicken
EDO46546      304 CQDMTQPLSHYFIASSHNTYLLDNQLSGRSSiEGYIAALQQGCRCVELDCWDGPYd--EPIIYHGHTLTSKIMFKETVEA 381  Nematostella ...
XP_001178766   85 CQDMTQSLSHYFIAASHNTYLTEDQLKGPSSvAAYVSALQKGCRWVELDVWDGANd--EPIIYHGHTLTSKILFKAAIEA 162  purple urchin
XP_002127460  396 CQDMNFPLSHYFIASSHNTYVMEDQVNGPSSvSAYVRALLRCCRCVELDCWDGDNg--EPVITHGHTPTNKISFRQVIEA 473  Ciona intesti...
XP_002166073  349 CEDMKKPLSHYFIAASNNTYLIEDQLTGKSSvEGFVSCLQRGCRYIELECYDGDEg--EPNIYHGNNCTLKLPFLDTIKV 426  green hydra
EDV21978      406 CEDMDQPLSHYFIASSHNTDLLEDQLTGPSSvEAYKSALLSGCRCVEMDCWDGPNn--EPVIYHGQSLTTKITFKSVIQA 483  Trichoplax ad...
EEN50680      304 HQDMTHPLSHYYVFSSHDSYLLPGVEYVPSL-NAYARLLQRGCRYVELVCWDGEHgddEPLVCHHPSETTRLRFRSVVEI 382  Branchiostoma...
Q9UPR0        503 INKYAFFASEYPLILCLENHCSiKQQKVMVQHMKKLLGDKLYTTSPNveesYLPSPDVLKGKILIKAKKLssncsgvegd 582  human
CAG11094      424 IEKCAFVASDYPLIVCIENHCSyQQQQVMCQHLTRIFGDKLYTDPPNqedsYLPSPHALRHRIILKGKKLgpgleaedge 503  spotted green...
XP_421916     406 INKLAFFASEYPLILCLGNHCSvQQQKVVVQHMKRIFGNKLYTEAPLsseaYLPSPEKLKMKIIVKGKKLpcdqdilege 485  chicken
EDO46546      382 IEEHAFDVSPYPVILSIENHCCvKQQQIMAKYLKEILKDKLYTEAPGedetFLPSPEALKGRILIKNKKLpasidndeea 461  Nematostella ...
XP_001178766  163 INQHAFETSEYPVIVSIENHCSpEQQRTMAHYITSVFGDKLHTDRIDedlsYLPSPHDLQGKILIKGKRLpddhegdege 242  purple urchin
XP_002127460  474 INESAFRNSPYPVILCIENHCSeLQQLVMANDLKQIFADKIYTENLAkgssELPSPESLQRKILIRGKKLplecdeevgy 553  Ciona intesti...
XP_002166073  427 IAENAFYSTDYPLILSIENHCStKQQLVMAQHLKMVFRDCLYDIPADeqyiHLPSPHFLRGKVIIKSKKLafkssesiss 506  green hydra
EDV21978      484 INEYAFVASEYPVILWIQNHCStKQQRIIAHYLKEILGDKLCNHFINenqkLLTSPRRLRRKIILKGKKLpvdckemegf 563  Trichoplax ad...
EEN50680      383 IAQYAFQASDYPLIIGIDNHCCeEQQIKIVNYIAATFGDMLVRSIVEeggvQLPSPYDLKKKSSSSLSSTndmqnals-- 460  Branchiostoma...
Q9UPR0        583 vtdedegae-----------------------------------msqrmgkenmeqpnnvpvKRFQLCKELSELV-SICK 626  human
CAG11094      504 vseedegaemcqkasnsasa-------------apggndndgvpkcsspttvtvstplhlhpKHFQLLKELSDLV-TLCR 569  spotted green...
XP_421916     486 vtdede----------------------------------------eaeisrrlsedfsrepKLIWLCKELSDLV-SLCK 524  chicken
EDO46546      462 gevsee----------------------------------------deyveenghdanknprKTTKLARELSDLV-SLCK 500  Nematostella ...
XP_001178766  243 vtdede-----------------------------------------gsdtdrgkkikkdgvKKRALIRELSDLV-TLCK 280  purple urchin
XP_002127460  554 vtdedegmevdd-----------------------------qspasppihvdtsshtssegdCKRALVRDLSNLV-SICT 603  Ciona intesti...
XP_002166073  507 ngdvseeeeekeicsgdvtelvdnevnhgtgtdndafqkipmttikssqlnasnspeesknvKTIKLAKEFSDLV-VLCK 585  green hydra
EDV21978      564 vsdeecsgh----------------------------------apengekkkakkdnanqnkKQVKLIKQLSDLInLKCI 609  Trichoplax ad...
EEN50680      461 ------------------------------------------------------tvkvkrekGRPPLCKELADLI-VLCK 485  Branchiostoma...
Q9UPR0        627 SVQFKEFqvsfqvQKYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRI-DSSNMNPQDFWKCGCQIVAMNFQ 705  human
CAG11094      570 SVRFVDFptssksQKSWELCSFHETLALRLATESPRDFVNHNKHFLSRVYPCPMRI-DSSNMNPQDLWKCGCQIVSMNFQ 648  spotted green...
XP_421916     525 SVQYKDFetsmkaQNYWEICSFSEAEASRIANEYPEDFVNYNKKFLSRVYPSAMRI-DSSNLNPQDFWNCGCQIVAMNYQ 603  chicken
EDO46546      501 SVTFQDFqysadnQKFWELCSLNEALARRLGNAYPEEFVNYNKRCLSRIYPSGKRV-GSSNYNPQDMWNCGCQLVALNYQ 579  Nematostella ...
XP_001178766  281 SVRFLGFnearqdQRYWEICSFVENTAEKFANMCPEDYVSHNKRYLSRVYPNPNRV-DSTNLNPQDMWNVGCQIVSPQIL 359  purple urchin
XP_002127460  604 SVRFSGFatheriHKCHATSSIHEQEAAKLVENEAGDFVNFTKKFLTRVYPSGVRM-DSSNFNPQDFWNCGVQIASLNYQ 682  Ciona intesti...
XP_002166073  586 LVRFQNFtfsseqQKYWEMCSFSENTARELCRIFPEELVIHNKKFLSHVYPNNVRL-DSSNFNPVEFWACGCQLVAMNYQ 664  green hydra
EDV21978      610 TFNGFQEake-nnRNYYETSSFEEVSALKLNQASPDEFVNFNKNYLSRIYPATKRV-DSSNYNPQDLWNCGCQLVAMNYQ 687  Trichoplax ad...
EEN50680      486 SDKIEDLptsaseSCAQYVCSFSQSGAIRLAVSFPEEFVNYNKKYMSEVHPDSNKDeDAINYNPQDYWNCGCQIVTVNYH 565  Branchiostoma...
Q9UPR0        706 TPGLMMDLNIGWFRQN 721  human
CAG11094      649 TAGLMMDLNTAWFRQN 664  spotted green pufferfish
XP_421916     604 TPGPMMDLHTGWFLQN 619  chicken
EDO46546      580 TPGIMMHVNSGKFLEN 595  Nematostella vectensis
XP_001178766  360 HIKIISGQQFPKPRGS 375  purple urchin
XP_002127460  683 TPGLMMDINDGRFAMN 698  Ciona intestinalis
XP_002166073  665 YAGIAMDINRGFFLKN 680  green hydra
EDV21978      688 TRGEMMDLHTGKFTEN 703  Trichoplax adhaerens
EEN50680      566 MPGLMTDLNDGRFLEN 581  Branchiostoma floridae
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