Conserved Protein Domain Family
PI-PLCc_GDPD_SF_unchar2

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cd08584: PI-PLCc_GDPD_SF_unchar2 
Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases
This subfamily corresponds to a group of uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipase C (PI-PLC), and glycerophosphodiester phosphodiesterases (GP-GDE), and also sphingomyelinases D (SMases D) and similar proteins. They hydrolyze the 3'-5' phosphodiester bonds in different substrates, utilizing a similar mechanism of general base and acid catalysis involving two conserved histidine residues.
Statistics
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PSSM-Id: 176526
View PSSM: cd08584
Aligned: 11 rows
Threshold Bit Score: 249.552
Threshold Setting Gi: 257126885
Created: 22-Feb-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Conserved Features/SitesClick to see Conserved Features Help
 
catalytic siteputative active
Feature 1:catalytic site [active site]
Evidence:
  • Comment:Phosphoinositide-specific phospholipase C, glycerophosphodiester phosphodiesterases, sphingomyelinases D, and similar proteins hydrolyze the 3'-5' phosphodiester bonds in different substrates, utilizing a similar mechanism of general base and acid catalysis involving two conserved histidine residues.
  • Comment:Based on structure evidence from phosphoinositide-specific phospholipase C and glycerophosphodiester phosphodiesterases catalytic domains.
  • Citation:PMID 1851953

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           #                                          #                                 
EEQ63272       3 ILSHRGWWqnenekntILAFQRSFQnsFGTEMDIRDyggGGHLVISHDMgs-ksSPAFESCLALYakn-nytFPLALNIK 80  Helicobacter pu...
YP_003164999   3 ILAHRGYWkkvsekntESALKKAFVkgYGIESDIRDy--VGKLVISHDPan-knCMLAEELFKELaky-nnnLCFAINIK 78  Leptotrichia bu...
YP_002549869   7 ILAHRGWWlepveknsETAFRRAFEngFGVETDTRDq--NGVLKIAHDMpvgdqVMDLDYFLDLHksy-agsGTIAMNIK 83  Agrobacterium v...
YP_001192706   3 IISHRGYWksqeeknkQISFDRSFKlrYGTETDIRDy--KGELVISHDIpd-enSLKIDDFFKIYntysnsnLTLALNIK 79  Flavobacterium ...
NP_790554      3 IISHRGYWlhkpernlTQAFHRSFDfgFGTETDVRDv--AGQLVISHDMpv-ggELTLDGLLDIMag---rnLPLAINVK 76  Pseudomonas syr...
YP_001760373   3 IVKHRINT--------RTILATTPHn-QGVEIDIRTi--GNRLILQHDPft--aGEALEQWLQEYk-----hKLLILNVK 64  Shewanella wood...
YP_001371292   3 VIHHRRNT--------VAELADTDPq-FGVEIDLRNh--GDDILVTHDPfi-trAVLLQDWLKQYr-----hRFLIANVK 65  Ochrobactrum an...
ZP_06011298    3 FIAHRINT--------KKELKNISEq-YGAELDLRDs-vDGKIYINHDPfi--lGEDFEEYLKEYn-----hGTMILNIK 65  Leptotrichia go...
YP_001011718   3 IIAHRINT--------INQLKDLNNn-FGVEVDIRSn--EKNLIIGHDPfs--nYINLKDWLSFYn-----hGTLILNVK 64  Prochlorococcus...
YP_003373071  13 WIAHRVNT--------VEQLRATPRe-FGVELDLRDh--GDQLILAHDPfv--gGERFEDYLAHYq-----hGLMVLNIK 74  Pirellula stale...
YP_003061572   5 LIAHRKNT--------ILDLNNTPKk-YGIEVDIRSr--GEDLIIHHDAfv--dGENFEHWIQNYn-----hGTLILNVK 66  Hirschia baltic...
Feature 1                                                                                        
EEQ63272      81 ADGLQIPLKKLLTQYNv-qNYFVFDMSIPDALLYLDMGf-kVFTRQSEYEINpsf----------ydKACGVWLDEFhs- 147 Helicobacter pu...
YP_003164999  79 ADGLGEKLSKLLKENNi-tNYFCFDMSAPQMIYYCENDf-nVFTRQSEYEVEpll---------lykESQGVWIDAFydd 147 Leptotrichia bu...
YP_002549869  84 ADGLHKALRASLEGAGi-tDLFCFDMAVPDAIGYLNNGf-iTYTRHSELEPLppf----------ydKAQGVWLDAFys- 150 Agrobacterium v...
YP_001192706  80 SDGLQVKLKEKLIEFGi-eNYFVFDMSIPDTIGYLKNNl-mTFTRQSEYEPIppf----------ieKCEGIWLDSFes- 146 Flavobacterium ...
NP_790554     77 ADGMALALKKTFARYGh-tNWFVFDMAVPDMRSYLIEEv-iTYSRLSDVEPSpaw----------leRATGVWLDGFds- 143 Pseudomonas syr...
YP_001760373  65 EEGLEHQIIEMMNQYNi-sNYFFLDQSVPFLIRTAKLGekrCAVRVSEYESIetal-------slqgLVDWVWIDSFnt- 135 Shewanella wood...
YP_001371292  66 EEGLEPRLTALLAEYGv-sDFFILDESIPFIRKYALEGlpnFAVRVSELESIetalriasylhgenrSINWIWADSFtg- 143 Ochrobactrum an...
ZP_06011298   66 SERIELRVLELLKKYNi-kDYFFLDSSFPMIKLLTDNGekkIALRYSEFEGLdtle-------kmqeKVDWVWVDCFtk- 136 Leptotrichia go...
YP_001011718  65 ENGLEEELIKIMKSFRk-eNFFILDQSFPYIIKTIENGekrCAIRLSEYESIntvl-------slkdKLNWVWIDFFtk- 135 Prochlorococcus...
YP_003373071  75 SERIESRVLEAIARAGtvrDYFFLDCSLPMVRQLTQRGehrIAARVSEIEPVegal-------alagSLDWVWIDCFsr- 146 Pirellula stale...
YP_003061572  67 EEGLEQRLLSIMQTQKi-dDFFFLDQSFPFLVRTSNLGesrCAVRVSEFENIatai-------tlagKIDWVWVDCFtr- 137 Hirschia baltic...
Feature 1                                                                          
EEQ63272     148 hFIDEALILEHLKnGKAVCIVSPELHkRDYQNEWEey-kIIDQKLKen-----dkLMLCTDYPCKA 207 Helicobacter pullorum MIT 98-...
YP_003164999 148 sWITEELILKHIKnGKKICLVSPELHsQSYLDFWKklkgFNIDYSK---------IILCTDVPDDA 204 Leptotrichia buccalis DSM 1135
YP_002549869 151 dWITPDVIQKHLDaGKKVALVSPELHgRDHTAAWDv--wGDLTGDD---------ISICTDLPHLA 205 Agrobacterium vitis S4
YP_001192706 147 tWYDKHILSKHLQsGKKVAIVSPELHkRNHLDLWKy--lKENNYHKsd------dIILCTDLPEDA 204 Flavobacterium johnsoniae UW101
NP_790554    144 eWFSNQVIGDLLSqDKQVCVVSPELHgRDCMALWQ----QLLEFRSen------rLTLCTDTPVDA 199 Pseudomonas syringae pv. toma...
YP_001760373 136 pYITSDMVHTLKKaNYKICLVSPELHsLNRGSEIItv-kQRIKNFKhm------iDAVCTKYPQRW 194 Shewanella woodyi ATCC 51908
YP_001371292 144 mPLHPDEALALRQaGYRICIVSPELHhVNDPASYEaralRYIEALKepgmessrpDMVCTKCPLLW 209 Ochrobactrum anthropi ATCC 49188
ZP_06011298  137 lPLNNEIYNKIKKmGYKLCLVSPELQgQPEKIEKYa---EQIKKEKii------fDSICTKVYNIE 193 Leptotrichia goodfellowii F0264
YP_001011718 136 fPVNFEIYKILKEhNFKLCFVSPELQgHQHSKCLDl--kNYIQFNQmy------fDAVCTKKVKFW 193 Prochlorococcus marinus str. ...
YP_003373071 147 lILDAPLAARLAG-KFKICLVSPELQgHPVAWIAEf--aQQLRGIRv--------DAICTKRIDLW 201 Pirellula staleyi DSM 6068
YP_003061572 138 fPLNKAEYDTLIAnKFKLCLVSPELQgRDADSGISam-aQLLREFDmt------mDAVCTKRPDLW 196 Hirschia baltica ATCC 49814

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