Conserved Protein Domain Family
PI-PLCc_GDPD_SF_unchar1

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cd08583: PI-PLCc_GDPD_SF_unchar1 
Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases
This subfamily corresponds to a group of uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipase C (PI-PLC), and glycerophosphodiester phosphodiesterases (GP-GDE), and also sphingomyelinases D (SMases D) and similar proteins. They hydrolyze the 3'-5' phosphodiester bonds in different substrates, utilizing a similar mechanism of general base and acid catalysis involving two conserved histidine residues.
Statistics
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PSSM-Id: 176525
View PSSM: cd08583
Aligned: 14 rows
Threshold Bit Score: 216.012
Threshold Setting Gi: 84393856
Created: 22-Feb-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Conserved Features/SitesClick to see Conserved Features Help
 
catalytic siteputative active
Feature 1:catalytic site [active site]
Evidence:
  • Comment:Phosphoinositide-specific phospholipase C, glycerophosphodiester phosphodiesterases, sphingomyelinases D, and similar proteins hydrolyze the 3'-5' phosphodiester bonds in different substrates, utilizing a similar mechanism of general base and acid catalysis involving two conserved histidine residues.
  • Comment:Based on structure evidence from phosphoinositide-specific phospholipase C and glycerophosphodiester phosphodiesterases catalytic domains.
  • Citation:PMID 1851953

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1          #                                           #                                
ZP_04853289  39 MVAHAMGGIEGltYTNTYDAFLVNYDQGfRVFEVDLLLSSEGRLVARHEWgesftrqlgqed----------elaadrqg 108 Paenibacillus sp...
ZP_02438271  89 SIAHAMGGLDGkdYLNSIDGFYPAYQKGyRVFEMDILLTKDNVAIGKHQWgrklsdpt------------------skkg 150 Clostridium sp. ...
ZP_03292967 321 YVAHALGGVGGktYTNSPQALEHNYNKGfRVFEVDLDLSSDDELIAWHSFdkvslkemgl--------------pekyat 386 Clostridium hira...
ZP_03293010 183 YIAHAMGGIDKkvYTNSLDAFEYNYKLGyRVFEIDVALTSDGQPVLLHSWdeprlkelgl--------------ptswnk 248 Clostridium hira...
ZP_02419861  92 AVAHALGEIDGkeYTNSKDAFLNSYQNGfRVFEADLMQTTDHVMVARHYWgkdlsdpk------------------skgg 153 Anaerostipes cac...
ZP_02326446  43 LIAHALGGISGeaATNSYEAFLANYEKGyRRFEADLILSSDGVLVARHDWdsylsdyiqst------------lpddeke 110 Paenibacillus la...
ZP_06424218 183 YIAHAMGGIGGntYTNSKEAMENSYKRGiRVMEADFSLSSDDKLILCHSFdtsslsslgl--------------plswnk 248 Peptostreptococc...
ZP_06405316  35 YICHGGGGIDGktYSNSLEAMQLNYNKGnRVFDSDMTFTKDGVLILRHSWadnleqrkismtnshsfvdrnghtqhllda 114 Prevotella sp. o...
ZP_04857915  54 TIAHALGGIGDktYLNSKESFLAGYQMGcRLFEVDLVKTSDNVWVCRHSWyqslgqwe------------------gdek 115 Ruminococcus sp....
ZP_02861207  28 VMVHACGKIDGyeYTNSVDALDMAIKKGgRYIEVDLSLTKDERVVCVHKWdkntferlg----------------iayrt 91  Anaerofustis ste...
Feature 1                                                                                       
ZP_04853289 109 avlSYAEFKAAKIQGvYEPLDWDDVLELMeqYPDVYIVTDTKQssp---deiQQIFTQIVDEAKakd-peLLKRVVPQIY 184 Paenibacillus sp...
ZP_02438271 151 dpvSYRKFKNTKIYGkYTPTSFLDVLNLMekYPDFYLMTDSKStep---adaKKEFNVLVQTAKkvgkedLLDRVIVQVY 227 Clostridium sp. ...
ZP_03292967 387 kkpTLEEFKRMKPYGkYDTMTFKDIIYYMteYPDIYMIIDLKQaen---dkvRKLYKKIVEEASp----eILDRMIPQIY 459 Clostridium hira...
ZP_03293010 249 nrpNFNEFINTEVCGvYKPMSFREVCELSkkYKDVRFVIDVKGdqq----mcKEVYKKCVKIAKevd-gkVLDKFIPQIY 323 Clostridium hira...
ZP_02419861 154 kpvSYAKFKNIKLYGkYTSVSLKELFELMdkYPDTYIITDTKDsda---aaaKNDFSVIVKTAKemkkeyLLDRLIVQIY 230 Anaerostipes cac...
ZP_02326446 111 gpiPFRDFKSHKIMGkYKPMGIKELIRLLymYPDTYLVTDTKEtdp---niiRKQFEIIVKTANein-pdVLNRIVPEIY 186 Paenibacillus la...
ZP_06424218 249 ekpSEREFLSKKILGtYHTMNFEDVAKYMkaHKDMYLVVDLKTndi---ksvEKSYRELVRVAKkvd-pdIMKRVIPQIY 324 Peptostreptococc...
ZP_06405316 115 nrmNYKTFMSKPIYRqYTPMDIKKLIVFLdkNKEAYIAPDMKDd-------pIKSYQYLVNEAIrlnkknVLDRIIVNIY 187 Prevotella sp. o...
ZP_04857915 116 kvlSSEEFLSRPIYGkYTPITFEDLLVLLsdYPDAFVMLDSKQyslrnyqktVEDYADYIELAEaagvpdVMRQVIPEIY 195 Ruminococcus sp....
ZP_02861207  92 eglSYDEFMKSKYYDnYSTMDLDMIIDYLkkYEDLYIMLDVTKdlde--edtKKIYELIIKGFEen--kkLLDRVVIEGG 167 Anaerofustis ste...
Feature 1                                                                                       
ZP_04853289 185 NrEMLEPVQSIYPFDSVIFTLYqth---dtdDEVVAFAADKHLAAVTmsd-traNAQLIQELNRiGVPSYIHTINDlkTI 260 Paenibacillus sp...
ZP_02438271 228 NqRMYWAVKSVHPFKHFVYTTYkqpd--aafYKVVKFCKQNGIEAITspk-ndiNDYRMELLAKqGIYSYTHSVNNayFA 304 Clostridium sp. ...
ZP_03292967 460 ReELYNEIMNIYNFKSASFTCYtmss--ideNKITNFCAMNGIKVLTidy-rflTSSLVEKCKSrGITLYMNTINDskEL 536 Clostridium hira...
ZP_03293010 324 DeKMLNDVMATYDFKSMIYTLYkqek--lnaQEVIDFSYENGIKVVVidk-eklNSKFIKELKQrGIYVYVNTYNDttKI 400 Clostridium hira...
ZP_02419861 231 NqPMYHAIKQVHPFRHFLYTTYqqtd--vafSKMIRFCTSNGIEAVTvpv-ssvNDYRMKLLSDaGLYSFTHTVNSvyEA 307 Anaerostipes cac...
ZP_02326446 187 SeDMLQIVRSVYAFPEMMLSVYmed---ipdDEALRILQEYQLTLIAipe-nraDAKFLRKLNEqHVHVYVHTINSveDY 262 Paenibacillus la...
ZP_06424218 325 YeEMYRPLMNIYNFKSMIFTTYrlee--lkaQKIVDFSYEHGIKIVAvnk-fkfSNVLTNKLLDrGISLYMFTYNDekIV 401 Peptostreptococc...
ZP_06405316 188 TyDLYDKIMKIYPFKNVTIRQHyvsp--nnyTELIEFCIKKNIHVVNlsl-cyvNDKGVNQIKSkGIHVYVAVVDYisDM 264 Prevotella sp. o...
ZP_04857915 196 NqAMFAGTALLYDFPGYIYSLWqeys-ikelTEIAAFCREKNIQAATvyy-kywSEDVQEIFDKkGIRLYIYTVNDlkEA 273 Ruminococcus sp....
ZP_02861207 168 SiEMFEAINSIFDFPNKHFYLTgkdineervDEILEYIKNDGHFVSVsshkknvKVDIIRKVHKlGIVYITYPINEpaEA 247 Anaerofustis ste...
Feature 1                         
ZP_04853289 261 AKFKRmGAYGFYTDFLTE 278 Paenibacillus sp. D14
ZP_02438271 305 KEFMKlGVYGVYSDFLSP 322 Clostridium sp. SS2/1
ZP_03292967 537 NKYKSqGVYGFFTDFLTP 554 Clostridium hiranonis DSM 13275
ZP_03293010 401 KELFGmGAKGIYSDFINP 418 Clostridium hiranonis DSM 13275
ZP_02419861 308 KEYMKlGVYGVYTDFLTN 325 Anaerostipes caccae DSM 14662
ZP_02326446 263 QRLKKlGVHGIYSDFLYK 280 Paenibacillus larvae subsp. larvae BRL-230010
ZP_06424218 402 NTLRNnYVSGFYTDFLPK 419 Peptostreptococcus anaerobius 653-L
ZP_06405316 265 QEYYKkGYSGACTNWLYE 282 Prevotella sp. oral taxon 299 str. F0039
ZP_04857915 274 QYYMQeGAAGVCSDYLQD 291 Ruminococcus sp. 5_1_39B_FAA
ZP_02861207 248 LKYFNfGVDIICSSELTK 265 Anaerofustis stercorihominis DSM 17244

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