Conserved Protein Domain Family
GDPD_memb_like

?
cd08579: GDPD_memb_like 
Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases
This subfamily corresponds to the glycerophosphodiester phosphodiesterase domain (GDPD) present in uncharacterized bacterial glycerophosphodiester phosphodiesterases. In addition to a C-terminal GDPD domain, most members in this family have an N-terminus that functions as a membrane anchor.
Statistics
?
PSSM-Id: 176521
View PSSM: cd08579
Aligned: 39 rows
Threshold Bit Score: 252.852
Threshold Setting Gi: 170018055
Created: 27-Oct-2009
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Conserved Features/SitesClick to see Conserved Features Help
 
Feature 1:catalytic site [active site]
Evidence:
  • Comment:The catalytic mechanism of glycerophosphodiester phosphodiesterases is based on the metal ion-dependent general acid-base reaction.
  • Comment:Based on structure evidence and site-directed mutagenesis of Thermoanaerobacter tengcongensis glycerophosphodiester phosphodiesterase, the catalytic site consists of two conserved histidine residues which serve as general acid and general base in catalyzing the hydrolysis of the 3'-5' phosphodiester bond.

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1           #                                           #                                
Q837Q4       343 IISHRGVTnsnGVQNTIPAMERTIKf-KPDYIEIDVQETKDHQFVVMHDANLQELAGVDgtpqEFTLAELTKMTvkengq 421 Enterococcus fa...
Q833P0       352 TISHRGVNgnnGVQNTLDSLIETNKa-KPDYVEMDIQETKDHQFIVMHDFNLRALTGVNkrpnQLTLKELTNMNvtengq 430 Enterococcus fa...
Q1WRI6       346 RISHRGVDdgnGVQNTIPAMAATIKe-HPDFIEMDIHETKDHQFVVMHDENLKNLTGVNkapyQLTLSQITKLVahengh 424 Lactobacillus s...
Q38Y42       346 SISHRGVSqknSVQNSLTALNQTHRl-KPDYVEMDVQLAKDHQFVVFHDFQLAPLTGHSgtpqSKTLAQLTNMTvrehkr 424 Lactobacillus s...
Q04KT6       338 LISHRGVSnanGIQNTVESLETTAQl-KPDLVETDVQETKDGQFVMMHDANLKNLAGINkspqDLNLEELKGIDifengy 416 Streptococcus p...
Q1WRS6       313 TIAHRGVNqknGVPNTLESLKKTIKy-HPDYIEMDVHMTKDNKFIVLHDNNLKKLAGIKahpeDLTLAELKKLNvtannh 391 Lactobacillus s...
YP_001728974 307 VIAHKGIAsekQAPNTLATLTQVAQt-KPDFVEIDIQPTRDGVYVLSHDGDIKATDGKSykidETSWQTLKTIRyrtkgq 385 Leuconostoc cit...
NP_785814    273 IIAHRGVNgrdGVQNTTVALKRTVKqvQPDMVEMDIQPTADRHWVVMHDPTLKALAGQPgpvhEYPVDKLSGLPlrehgq 352 Lactobacillus p...
ZP_03956721  260 IVAHRGSDgnnGVPNTVPTLKDSKKklSPDYSELDVRQTVDGRFVVIHDAMLANSSGKErevnNLSLGDLIEHKvkesgh 339 Lactobacillus r...
ZP_01544876  218 IISHKGSNgnnGVPNSLQSLKSTSRl-KPNYIEVDVRYTKDHQFVVMHDDNLKSLTGKNlkpeQATLEQLEKITmkavgh 296 Oenococcus oeni...
Feature 1                                                                                        
Q837Q4       422 eaPIASFDDYLAKANqakQKLLVEIKtskq--dsqGALSNFIEKYErpliknNHQVQSLDYnVIKAFKkakSKVKVSFIL 499 Enterococcus fa...
Q833P0       431 taKMVSFDDYLAKANqlkQRLLIEIKttpq--dspDLVQRFVKQYRenifenGHILHTLTYdTAMALKkeePRFYVGYVI 508 Enterococcus fa...
Q1WRI6       425 aaHVVSFDDYLAYANkhhQKLLIEVKttph--dskDVVDIFLKKYKknilkhHHEVHSLDYnVVKQIKaktPKIFVSYIL 502 Lactobacillus s...
Q38Y42       425 taPIASFDDYLALANqrhQKLLIEIKtpat--dnpGLVQKFLAKYEtnieahDHMVQSLNWqVVEDVKkaaPQIQTGYIL 502 Lactobacillus s...
Q04KT6       417 qtKISSFEDYLSRANelgQKLLIEIKtskk--dspDMMNRFLARYAaklkiyGHQIQSLDYhVVEKVRqydAELPVYFIM 494 Streptococcus p...
Q1WRS6       392 qtKLTDFDTYLKYANqhhQKLLIELKttpn--natDFANIFAKRYYaniienHHQLHTLDFqPLMILQndiPKGNLNYLM 469 Lactobacillus s...
YP_001728974 386 tlRVTSFNDYISRANqlhQKLLVELKisdt--ittQALLDFQNRYGqalkanHAQLQSLNQnIIKRLSe-hMDQPMGLLS 462 Leuconostoc cit...
NP_785814    353 kgYLSTFKQYFAVAHklqQPLLVEIKsvg---tadQLMGIFADNYAqrliqqKGAVHSLDYrVIERLHqraAQLPVGFIT 429 Lactobacillus p...
ZP_03956721  340 aaYLSGYSQYLEAAHqikQPLITEIKtdeh--dnyDLAAEFCHLYAdsmidhGDMVHSMDYrIIANVKkseKRLKCGYVL 417 Lactobacillus r...
ZP_01544876  297 qtKITSFQKYANYAWnhgQKLLVEIKtpsisqkyeSLSKVFLSEYGkslvkhHDLIHSLNQgLINSIHkkdPNLKVGFII 376 Oenococcus oeni...
Feature 1                                                                        
Q837Q4       500 PYnft-fpeTQADLYTMEattlNDTFILKADqqKKAVYAWTVNdseVLSKMLFmDVAGVITDDL 562 Enterococcus faecalis
Q833P0       509 PFnivgppkMPVDFFTMEystmNRNFVNAAHhdGKKVYAWTANdedVMTRMIFyGVDGIITDQL 572 Enterococcus faecalis
Q1WRI6       503 PYnft-ypqTSANAYSMEqstlNDSFIVDSLfnQQKVYAWTVNtdsEMDRILWlNTDGIITDNL 565 Lactobacillus salivarius subsp....
Q38Y42       503 PFnfigppiSHADFYAVEmttvNRHFIQAAHqeKKAVFVWTPNdqqAVQRMMYfGADGVITDNL 566 Lactobacillus sakei subsp. sake...
Q04KT6       495 PYnsv-fpkTRATGYTMEystlDEYFVSKLWttDQKLYVWTVNdseAISKSLHlGVDGVITDDL 557 Streptococcus pneumoniae D39
Q1WRS6       470 PYnlt-ipkENIHAYGMRystlSPDFVAINRqkHKLVYTWTPNsrlAINEALSlGVYGIVTDNV 532 Lactobacillus salivarius UCC118
YP_001728974 463 PVvnsidgaKFSRFYAIEysnaNANLAQRVTqyHKALYVWTLNqksDIATAYAlGVTGYITDYP 526 Leuconostoc citreum KM20
NP_785814    430 PFyltdfsnSVAEFYSLQaltaTREQISAAHrqHRIVYFWTVDrplAMQRLTAmGADGLITNRP 493 Lactobacillus plantarum WCFS1
ZP_03956721  418 PFeifsmpkGAIDFYSIEyltmNRSFIKAAHdkKKKVYVWTVNnklDCLRACAiGADGVITDNG 481 Lactobacillus ruminis ATCC 25644
ZP_01544876  377 SYnteslphKGNNFYTIEystlDNELVGTVHrqGKRIFAWTSDdalSMHWLSVmNVDGIITDYP 440 Oenococcus oeni ATCC BAA-1163

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap