Conserved Protein Domain Family
GDPD_NUC-2_fungi

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cd08578: GDPD_NUC-2_fungi 
Putative glycerophosphodiester phosphodiesterase domain of ankyrin repeat protein NUC-2 and similar proteins
This subfamily corresponds to a putative glycerophosphodiester phosphodiesterase domain (GDPD) present in Neurospora crassa ankyrin repeat protein NUC-2 and its Saccharomyces cerevisiae counterpart, Phosphate system positive regulatory protein PHO81. Some uncharacterized NUC-2 sequence homologs are also included in this family. NUC-2 plays an important role in the phosphate-regulated signal transduction pathway in Neurospora crassa. It shows high similarity to a cyclin-dependent kinase inhibitory protein PHO81, which is part of the phosphate regulatory cascade in S. cerevisiae. Both NUC-2 and PHO81 have multi-domain architecture, including an SPX N-terminal domain following by several ankyrin repeats and a putative C-terminal GDPD domain with unknown function. Although the putative GDPD domain displays sequence homology to that of bacterial glycerophosphodiester phosphodiesterases (GP-GDEs, EC 3.1.4.46), the residues essential for interactions with the substrates and calcium ions in bacterial GP-GDEs are not conserved in members of this family, which suggests the function of putative GDPD domains in these proteins might be distinct from those in typical bacterial GP-GDEs.
Statistics
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PSSM-Id: 176520
View PSSM: cd08578
Aligned: 15 rows
Threshold Bit Score: 341.224
Threshold Setting Gi: 50542922
Created: 11-Jan-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q01317        721 ETYWKATSQFDTn------------------------------------------------------------------- 733  Neurospora cr...
XP_002490809  723 ETYWKSTNNQSSqqlv---------------------------------------------------------------- 738  Pichia pastor...
XP_759007     744 ETYWKSMLPGVAaastvgptrmtpnsgvsgiggslssksaaagptq-------avadksatassngavgtpsvgssgaas 816  Ustilago mayd...
XP_001728990  679 ETYWKSTLPSHNqpltvsplpy-------------------------------------------------------png 703  Malassezia gl...
EEQ83519      684 ATYWKATSTLDSd------------------------------------------------------------------- 696  Ajellomyces d...
XP_499627     718 DTYWKSTGTSQQ-------------------------------------------------------------------- 729  Yarrowia lipo...
XP_570719     980 ETYWKSKVVKGDsaqdhahlapnkplsvfsssgavagaigaaaagavghgvgleegkvsdvgvssgadtgmstvpaagaa 1059 Cryptococcus ...
XP_002552299  789 ETYWKSTTGNETgk------------------------------------------------------------------ 802  Lachancea the...
XP_002495595  799 DTYWKSSGGADAdag----------------------------------------------------------------- 813  Zygosaccharom...
XP_001645800  844 ETYWKSTSNDMTik------------------------------------------------------------------ 857  Vanderwaltozy...
Q01317        734 ------TSTFVTGSSlSGDFVQIYVQHTKDGVPVLWPRWTIncg-gidVPVSTLTLAQFQTVtaaarnrinls------e 800  Neurospora cr...
XP_002490809  739 ---kstYFSFVTASSlSGQYYRVKVFLSHDGIPLVAPEWYLelapnlrVPISNFTYSQLKVMllhnhdipe--------- 806  Pichia pastor...
XP_759007     817 ataaaaQPTLVTGSSlAGEYLRVVVQVTKDAKAVVWPAQFIplp-glqVYVGSVTSEEFLSVatqtgrsldwt------- 888  Ustilago mayd...
XP_001728990  704 thdaqdTALYVTASSlSGEYLNVNVHFTKDLVPVVCASRRLpvp-vwaPFVSQVTATEFADIaektghtwht-------- 774  Malassezia gl...
EEQ83519      697 ------HNGLVTGSSlSGDYVQVFVQLTKDGVPVLYPEFTVnhh-gidIPICRLSFEQFRAIhaeylaqtrsedaallks 769  Ajellomyces d...
XP_499627     730 ------SLSFVTASSvSGQYARLTICVTSDGVPVVTPSWKVdvghgirVGVNTLTYEELKKCtngvvsdl---------- 793  Yarrowia lipo...
XP_570719    1060 sgggggESALVTASSlSGEYVHVVVQVTKDGVPVVYPHGRLpvk-efdLGVSDVTYDQFMALatrlglalqpp------- 1131 Cryptococcus ...
XP_002552299  803 -----sGNQFITSSL-SGTYTNFFLFPLNDGTLIVSPKKAFstg-pmdLKIFDLNANQLEKLmgyslqgn---------- 865  Lachancea the...
XP_002495595  814 ----kdGHRVVTSSSlSGSFINVTVCTLNDGTIIAAPNAFFevk-sakLFFNDLTRDQLEKMcdyrldem---------- 878  Zygosaccharom...
XP_001645800  858 ----kdLHQFVTSSSlIGRYASLKVCSLNDGTIVVTPMLYItig-tikIFMNDLSKNQLESFlsyniedv---------- 922  Vanderwaltozy...
Q01317        801 lstytldqiaDVHRIL-ANIGITLHEALFLLPkGMHVNIQVLYPTAdekaeak------------sstaadDVNEFADAI 867  Neurospora cr...
XP_002490809  807 -rtanvkdfkQLEILLdQLKCIPLQVLLENLPiNLSIDLEIFYPTLyeltfadlplarlnvkgnelilktnEINYYTDTI 885  Pichia pastor...
XP_759007     889 paqaaqaswvDWQRAL-ERSVVTLETLLSLLPvSVGIDIDVMYPSTaevrsn-------------pgmpkmEVNQFVDTI 954  Ustilago mayd...
XP_001728990  775 -neseslamnEWSAKL-STTLVSLETLLVTLPpSVNVALQIVFDADat---------------------vvPLNACIDAT 831  Malassezia gl...
EEQ83519      770 ledmtvddmaQAHRLL-ATSFLSLKEVLEHLPtNIHVDLCILYPSPaeeakl-------------glgplaDINTVADAI 835  Ajellomyces d...
XP_499627     794 ---stvsdpvEVHRVL-SNSTLPLAEVLKLLPiTVKLDLNVIFAAS-------------------------DLNHYVDTV 844  Yarrowia lipo...
XP_570719    1132 sslsyqstasDWYNLL-SSTLASLTDVLTLLPhEIGINLRLRYTREvdsssvgk----------kvgresgEVNKWVDTV 1200 Cryptococcus ...
XP_002552299  866 ---hegskevTYEQLL-NERFTTLETLLNNTPpNAKLEIEVCFPTAcefesip-----------lklsplvNINDFIDNV 930  Lachancea the...
XP_002495595  879 ---plisdpgDLKQVL-SSRIVLLSEVLNKVSpSIQLEIQVSFPTNleiedip-----------vkispfvDLDGIIDHV 943  Zygosaccharom...
XP_001645800  923 ---peinnfeDLIPLL-NSKVYSLDKLLTKIDnTIQLDIQLCYPTEqevneip-----------vkmgplhDLNSFIDKV 987  Vanderwaltozy...
Q01317        868 LSVVFDHARaqrae--------rpdsvRSVVFSSYNPtLCTALNWKQPNFPVFLCNDMgredrkqqqqgscskgdgdedm 939  Neurospora cr...
XP_002490809  886 LTTVFDHVRssrqti------qhdqktRSMIFSSSNPsICTILNWKQPNYPVLFNMSGvvfddeektfkyvsangfpile 959  Pichia pastor...
XP_759007     955 LHTVYAAGTsnr------------eqsRKILFSSRSPtVCTALNWKQPNYAVFFASFCgidgmaslergql--------- 1013 Ustilago mayd...
XP_001728990  832 LHVVYDVARrek-------------hrRRLFFSSTMPsACVALNWKQPNYAVFFINNAtldadaavls------------ 886  Malassezia gl...
EEQ83519      836 LTDVFTHARvsket--------npdfmRSVVFTSYNPnICIALNWKQPNYPVLLCNDLgqirdltqdvss---------- 897  Ajellomyces d...
XP_499627     845 LDVLFAHARdthdtnrmsngdpapratRSIILSSVNPdVCTALNWKQPNYPVFFVMRNgtfnept--------------- 909  Yarrowia lipo...
XP_570719    1201 LDSVYEVGKkvgge---------ggkaRKIIFSSFDPvVCTALNWKQPNYAVFFASYCgvsrqsslptstsirssdrdtt 1271 Cryptococcus ...
XP_002552299  931 LSSSFAHARqrfh----------ngmtSSIVFTSRNPeVCSILNWKQPNFPVLFYMNGlrkengvlvkdtphhls----- 995  Lachancea the...
XP_002495595  944 LLLVFEHVRylrhs---------gqniRSIVFSSCNWqACGILNWKQPNFPVLFHIKGlkrsnglfimdtphnlr----- 1009 Zygosaccharom...
XP_001645800  988 LLVVFDHVRdlrhs---------gkdlRSIVFSSSNQqACVSLNWKQPNFAVLYRMGVlyregdefvtdtahhlk----- 1053 Vanderwaltozy...
Q01317        940 gg----------------ttaasrreaadertlqsdgrrtsSIKDVVRTAtSNNLMGLICCSRLLdmvPALVDAIKShGL 1003 Neurospora cr...
XP_002490809  960 dfertltkdrsnikldnidsinkkesnsytdelvnqhciskSIKQAVFFAtSNNLLGIIVSNQLLkvcPRLIEDIRSrGL 1039 Pichia pastor...
XP_759007    1014 ----------------------------lpstrhetdprreSISEAVRFAkSNNLLGIMVDVALLnhvPHLVESVKAsGL 1065 Ustilago mayd...
XP_001728990  887 -------------------------------lpeeadprqsSMAEAVRFAkGNNLLGVMLDTSILecvPELITAVKAaGL 935  Malassezia gl...
EEQ83519      898 -----------------------------lpvirssgrssmSIKESARIAqSNNFMGLMCRSSLLnvmPSLVESIKElGL 948  Ajellomyces d...
XP_499627     910 ----------------------------------dldrvsvSVKEAVLFAnGNNMLGLVCDARLLnlvPALVESICSsGL 955  Yarrowia lipo...
XP_570719    1272 hgpspyi------tgehgqggrptrrlipapreeesdvrclSVREAVNFAkSRNLLGVILEASTLsavPSLVASVKDaGL 1345 Cryptococcus ...
XP_002552299  996 ------------------------hlsmdpekvnykepcsrCIREAVQFAsYNNLLGVIVPLELLrssQQLVSEIRGrGL 1051 Lachancea the...
XP_002495595 1010 ------------------------dlavdpakvnfaqersrGIHQIVSFAaNNNLLGIIVPYDLLkicRLLIGAIQGqGL 1065 Zygosaccharom...
XP_001645800 1054 ------------------------seavnkkilnltnhenyYLREIVRDAtNNNLFGIILPYELLqvcSQIGSTIRSnGL 1109 Vanderwaltozy...
Q01317       1004 ALVVDKsgepeaanskdsgdk------------------qlgisgalgglagsDPFPKLPkgVDGLLKSNGVLR 1059 Neurospora crassa
XP_002490809 1040 ILVASEn---------------------------------------------nKTPYDIIddVNGLRLNDILTF 1068 Pichia pastoris GS115
XP_759007    1066 LLITIGkfkrqq------------------------------------slpqlEEVAELVddVDGEVDQGIVVC 1103 Ustilago maydis 521
XP_001728990  936 VLITLRrpssnasatda--------------------------tsfsepgflgPPALACHdaIDGFLEGNVIKC 983  Malassezia globosa ...
EEQ83519      949 VLVADTsdeildktrfglgsgklashdrnheqqqgragagvgigvgvgvgvsaEWAYKMPegVNGVVRGNGVLR 1022 Ajellomyces dermati...
XP_499627     956 VLVSDGe----------------------------------------------HECKGVKamRNESVVEFHNSI 983  Yarrowia lipolytica...
XP_570719    1346 LLAAFGepad---------------------------------------isvlRQGADDGrtIDAFVLEGIMTL 1380 Cryptococcus neofor...
XP_002552299 1052 LVIGSLfeg------------------------------------------enIAVDLAGedINGVRTHDTLQF 1083 Lachancea thermotol...
XP_002495595 1066 LLVGSIed--------------------------------------------dQQGVIDDdeINGLHTEYELLF 1095 Zygosaccharomyces r...
XP_001645800 1110 LLIASLes--------------------------------------------eSENVLHNddINGTLIGSKLEF 1139 Vanderwaltozyma pol...
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