Conserved Protein Domain Family
PI-PLCc_GDPD_SF_unchar3

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cd08577: PI-PLCc_GDPD_SF_unchar3 
Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases
This subfamily corresponds to a group of uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipase C (PI-PLC), and glycerophosphodiester phosphodiesterases (GP-GDE), and also sphingomyelinases D (SMases D) and similar proteins. They hydrolyze the 3'-5' phosphodiester bonds in different substrates, utilizing a similar mechanism of general base and acid catalysis involving two conserved histidine residues.
Statistics
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PSSM-Id: 176519
View PSSM: cd08577
Aligned: 25 rows
Threshold Bit Score: 235.612
Threshold Setting Gi: 256722419
Created: 15-Dec-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
catalytic siteputative active
Feature 1:catalytic site [active site]
Evidence:
  • Comment:Phosphoinositide-specific phospholipase C, glycerophosphodiester phosphodiesterases, sphingomyelinases D, and similar proteins hydrolyze the 3'-5' phosphodiester bonds in different substrates, utilizing a similar mechanism of general base and acid catalysis involving two conserved histidine residues.
  • Comment:Based on structure evidence from phosphoinositide-specific phospholipase C and glycerophosphodiester phosphodiesterases catalytic domains.
  • Citation:PMID 1851953

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             #                                                                 #        
ZP_01961322   34 ENVHSHNDYLq-NVPFYTAYSARcASIEADVFLv------------------------------DGELYVAHKENEINk- 81  Bacteroides cac...
AAT92587     115 MPVHSHNDYWr-KLPLFEGLAYGaSSTEADVWNi-----------------------------dEKILAVGHNEAYLDpv 164 baker's yeast
XP_002492299  93 IPIHSHNDEWr-RLPLYDALKVGaQSVEADIWYfd---------------------------sdPETIFVGHNKVFLSs- 143 Pichia pastoris...
EAZ63055      38 KPLHSHNDYWr-SQPLFDALSIGaVSVESDVWYfpqgfnvsrtvtqtsddgltqtksnvthrfrNDEVFVGHSQVFLQp- 115 Pichia stipitis...
EDK40271      32 KPIHSHNDYWr-HRPLFDALSFGcASVEADVWIfdknytvvpe-----------tettstkefgDNEVYVGHNQLYLQp- 98  Pichia guillier...
XP_773457    161 IWANSHNDEMqgKGALTLALKQGfGYIEIDTHLdass-----------------------lrnsSLTLLTGHDISDLNs- 216 Cryptococcus ne...
EDP50794     142 VQCHSHNDYWr-SVPLYEALAAGcTGVEADVWLe------------------------------GSDLLVGHGKRSLTp- 189 Aspergillus fum...
EEU35803     165 VMCHSHNDYWr-LHPLFSALAVGcASTEADVWLsp----------------------------dGKDLLVGHDRQSLSs- 214 Nectria haemato...
XP_001588077  42 INCWSHNDEHq-PISLYTALAAGcIAIEADCFTpsyysssyfpasl------fsyfsspevpipENDLLVGHETSELHl- 113 Sclerotinia scl...
NP_982758    121 TRVHSHNDYWr-RVPLLQALAYGvASVEADVWLen----------------------------nGTTLLVGHNRVFLEp- 170 Ashbya gossypii...
Feature 1                                                                                        
ZP_01961322   82 ARKLRNLYLNPIREQFEmnggsg-----------------------ypngksFQLLIDLKTDyk--eTMKVLEQQLLEYR 136 Bacteroides cac...
AAT92587     165 ELTLDKLYTGPLLEILDevncqdsdadrk------------ngvffnspetsLFFYIDFKSDdneltYKLLMEQYFKSLI 232 baker's yeast
XP_002492299 144 KWNLDDMYLNPLFSLIGqnniakrfedenvs-------trrngifynnlhqtLYFYLDIKSNge--kTMAALEDKLSHFI 214 Pichia pastoris...
EAZ63055     116 INTLFNLYLNPLFDFLTyvnpvftvsgnvist-----skdlysvfynspeqpLLLWLDFKTSpn--eTYDAIRPLLQPFI 188 Pichia stipitis...
EDK40271      99 NNTLWSLYLGPIYSFLNsvnpafryndgsnqsallgdtttkhglfynspevpLHILFDVKTEan--sTYAALKSQIQPFI 176 Pichia guillier...
XP_773457    217 NRTVKDLYLDPLLAILDahnqgwtpggekn----------wtgvyeddpreeVTLFFDIKSDgd--aTWPYLEAALEPFL 284 Cryptococcus ne...
EDP50794     190 DRTLRSLYIEPLTTILSnlnadssants-------------agvfetdpttsLTLLIDIKSDgn--aTWPVLLDQLAPLR 254 Aspergillus fum...
EEU35803     215 SRTLRSLYLDPLLQILNsmnplvlqeglnst-------aqargvfaiqpnttLILFVDVKDDpv--sTWPLVLEQLGPLR 285 Nectria haemato...
XP_001588077 114 TRTLSALYLNPLLEILIqqnkaagnptqr------------vgvwnenpylpLHLTIDYKTVssghdGIPILHSLLEPLR 181 Sclerotinia scl...
NP_982758    171 AHDLGRLYIEPITRMLQevncksenkgdp------------ygifynapeeqLLLYIDFKSLdr-klTYKLLLDYLKPLI 237 Ashbya gossypii...
Feature 1                                                                                        
ZP_01961322  137 DCFdvkk-------------nplAVRVVVSGFlpspe----------efsnYADFIFFDGrprf-----------iytPE 182 Bacteroides cac...
AAT92587     233 DSGyltyydmk-----kdeiiwrPVTVILTGNyptsldildngndngyfesSQRFAFLDAplls----------lepkYS 297 baker's yeast
XP_002492299 215 NNEylsyydse-----tdefvegPITVIITGNypydf----------ivskTKRFFFIDAplfkf--------kddeeLA 271 Pichia pastoris...
EAZ63055     189 DNNflayydve-----adklvpgPLVVTITGNlplek----------veaeSKRYTFLDGplkyf--------ntsanEA 245 Pichia stipitis...
EDK40271     177 DAQylthydtt-----qkkwipgPLTITISGNqatel----------vkeeTVRYMFLDSplvnm--------ksnasTE 233 Pichia guillier...
XP_773457    285 SKGylttyntt-----sntltpgPLTVVGTGNtplhr----------vyysSLRYIFYDApllelyqpytlpasqygpET 349 Cryptococcus ne...
EDP50794     255 SGGwlshwngt-----sktlvngPVTVVGTGNtlfdl----------vlaeEDRYVFFDApld------------elaQN 307 Aspergillus fum...
EEU35803     286 DRKylarhekmhtmttnqsfwpgPVTIVGTGNilkrrdinm--gadpekwqQYHDVFLDApldllt------etgfspSS 357 Nectria haemato...
XP_001588077 182 TAGfltyydtl-----neklvpgPLTIVGTGDadfe-----------licaYERVYIFKDarff----------nflpSQ 235 Sclerotinia scl...
NP_982758    238 DNNfisyydmd-----akrfvsrPVTVVLTGNypsdee--------igvpsPRRYTFLDApl--------------grLS 290 Ashbya gossypii...
Feature 1                                                                                        
ZP_01961322  183 QSLRIp--------mMSTSFRtl----tQWNGLGRMvet---dynKVKAFIDKAHaeGKAARFWGcpd-----tktAWNT 242 Bacteroides cac...
AAT92587     298 KLSVAat------vsFSQLMKhcg--sdHWKVSLRGrmds-neisCAKSIIDGAHalKLKTRIWGaptwpanlvetISRQ 368 baker's yeast
XP_002492299 272 KYNHSsis----lasSASLYElte--srRALGGVSGlses--qveTISSYIDIAHnnDIKVRVWEtpswpirtrneVWKQ 343 Pichia pastoris...
EAZ63055     246 ELERWskl----syvASSSLAdll--gdDYESSVHSeftp-sqknTLGQFFDSAHkyGLKTRIWGditwpfnllnsHLLD 318 Pichia stipitis...
EDK40271     234 SLQEYsql----aviASASLEqll--gkNLYASVATqelgdqaktTLKNYFDTAHklGLKTRIWGgntwpihirnaQMST 307 Pichia guillier...
XP_773457    350 TIYWHpti----spiASAKFPlqsylalGPGSRGGGinp---fscNLKLTSAIAKqmGIQSRWWGvlhkpgwarriLWEM 422 Cryptococcus ne...
EDP50794     308 STYTAens-----yyASVSLQks---vgVVWPWGPTdnq----kqAMQKMISAASerGLLARFWSipswpvslrmrLWRF 375 Aspergillus fum...
EEU35803     358 DFSCHdesen-efytASASFKkt----iRGVRAGFNkhq----liTLRDQIQIARqrNLKSRYWGlpcwpisyrdyVWRI 428 Nectria haemato...
XP_001588077 236 NPYNSl--------yVSANIStsi--grFSKSKGPTkeq----vkSIRKECREVRerGLIPRYWGtpd-----deeWWRV 296 Sclerotinia scl...
NP_982758    291 SVGDEftannvsvvaSSSLLElml-rcgKASNPSLTeqtawesygCLVEYVREAHrrDLRARIWGlpdwp-vstreNLWD 368 Ashbya gossypii...
Feature 1                      
ZP_01961322  243 FMKLGl-DYLNTDH 255 Bacteroides caccae ATCC 43185
AAT92587     369 IIHDLgsDLLNLDN 382 baker's yeast
XP_002492299 344 LITLGv-DTLNVDD 356 Pichia pastoris GS115
EAZ63055     319 YYRLGs-DLLNVDD 331 Pichia stipitis CBS 6054
EDK40271     308 LWELGc-DLVNADD 320 Pichia guilliermondii ATCC 6260
XP_773457    423 VWESGa-GVMNADE 435 Cryptococcus neoformans var. neoformans B-3501A
EDP50794     376 LVDSGv-GMLNVDD 388 Aspergillus fumigatus A1163
EEU35803     429 LTREGi-DLLNADN 441 Nectria haematococca mpVI 77-13-4
XP_001588077 297 LVESGi-EVLNCDD 309 Sclerotinia sclerotiorum 1980 UF-70
NP_982758    369 MLTDMgvDYLNVDD 382 Ashbya gossypii ATCC 10895

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