Conserved Protein Domain Family
GDPD_GDE5_like

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cd08572: GDPD_GDE5_like 
Glycerophosphodiester phosphodiesterase domain of mammalian glycerophosphodiester phosphodiesterase GDE5-like proteins
This subfamily corresponds to the glycerophosphodiester phosphodiesterase domain (GDPD) present in mammalian glycerophosphodiester phosphodiesterase GDE5-like proteins. GDE5 is widely expressed in mammalian tissues, with highest expression in spinal chord. Although its biological function remains unclear, mammalian GDE5 shows higher sequence homology to fungal and plant glycerophosphodiester phosphodiesterases (GP-GDEs, EC 3.1.4.46) than to other bacterial and mammalian GP-GDEs. It may also hydrolyze glycerophosphodiesters to sn-glycerol-3-phosphate (G3P) and the corresponding alcohols.
Statistics
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PSSM-Id: 176514
View PSSM: cd08572
Aligned: 36 rows
Threshold Bit Score: 254.897
Threshold Setting Gi: 85691153
Created: 27-Oct-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:catalytic site [active site]
Evidence:
  • Comment:The catalytic mechanism of glycerophosphodiester phosphodiesterases is based on the metal ion-dependent general acid-base reaction.
  • Comment:Based on structure evidence and site-directed mutagenesis of Thermoanaerobacter tengcongensis glycerophosphodiester phosphodiesterase, the catalytic site consists of two conserved histidine residues which serve as general acid and general base in catalyzing the hydrolysis of the 3'-5' phosphodiester bond.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             #                                                         #                 
Q9NPB8        319 LDVGHRGAGNStttaq--------lakvqENTIASLRNAASHgAAFVEFDVHLSKDFVPVVYHDLTCcltmkkkfd---a 387  human
EFA81619      957 SLIGHRGNGKNnfgin--------tsavtENTILSFLTAARFgAKMIEFDLQLTYDNVPVIFHNYEIdietse------- 1021 Polysphondyli...
XP_001313062  115 LCIGHRGFGMNkvsp-----------silENTVTSFNHAMKHgSDMIELDVQFTKDQIPVIFHDFTIkcnksipnekpvs 183  Trichomonas v...
XP_965976     165 KAIGHRGCGENrltt----------tnlmENTISSFLEAYRRgAKWVEMDVQLTKDEVPVVFHDFGIqtg---------- 224  Encephalitozo...
XP_001580767  116 IAIGHRGSGANvvak-----------eflENTMPGFMKAYERkADVVEFDVQLVDDETPVIFHDFTLevkepiegikpns 184  Trichomonas v...
CAL50333      338 AVIGHRGLQANrqsg----------agirENTLASFIAASQGgAEWCEFDVQVTADGVPVAWHDDIViirrgn------- 400  Ostreococcus ...
XP_001693345   75 LLGGHRGMGENlashdvdgqplsvypayrENTIESFQQAAKCgVGFVEFDVQVTRDNVPIIWHDDDVvfgaa-------- 146  Chlamydomonas...
XP_001768871   11 IVIGHRGNGKNrtllqgei--pderpsfrENTINSFNTASKFgASFVEFDVQVTRDGHPIIFHDDYIiledk-------- 80   Physcomitrell...
XP_002501246   76 AVVAHRGLGMNlkpg----------kgirENTVASIIAAHDFgADWSEFDVQVTKDGVPVLWHDDFIsvrrgd------- 138  Micromonas sp...
EEH54903       79 AVIGHRGDGMNrcsg----------sgirENTVASFIAARDAgASWVEFDVQVTRDGVPVLWHDDVMlvkrgv------- 141  Micromonas pu...
Feature 1                                                                                         
Q9NPB8        388 dpvelfeIPVKELTFDQLQLLklthvtalkskdrke-------------------------------------------- 423  human
EFA81619     1022 --gvimqETINRLTLEQFLRLkpqkkvdqisnaishmkkhrlsrstgd-------------------------------- 1067 Polysphondyli...
XP_001313062  184 eengiyeYAVYQLTLEQLHNWgiesn------------------------------------------------------ 209  Trichomonas v...
XP_965976     225 ----gsyAGINEVTLEEFLSLvgnpde----------------------------------------------------- 247  Encephalitozo...
XP_001580767  185 veegkilYAWQQLNTKIHRESglttd------------------------------------------------------ 210  Trichomonas v...
CAL50333      401 --gplesFSIREIDWAELRELsasarsnasrpvdalavenaiastededyddd--------------------------- 451  Ostreococcus ...
XP_001693345  147 --dapqrPMVKDLTLAELQALcgrggntststaatasataaghgtgaadlpssdshfqqphvlrgtsedgsvvstprggs 224  Chlamydomonas...
XP_001768871   81 ---vlptTKIGELSLEEFLACgpqkdkstdgrtlyrk------------------------------------------- 114  Physcomitrell...
XP_002501246  139 --gevenSAIRDLTIEQLKKLvrpiteteepvviyrkf------------------------------------------ 174  Micromonas sp...
EEH54903      142 --gevesHRIRDLTLAEIKALsrdamataartreeeanrnimpdrcsgsenrsqplersss------------------- 200  Micromonas pu...
Feature 1                                                                                         
Q9NPB8        424 ----------------------------------svvqeensfsenqpFPSLKMVLESLPeDVGFNIEIKWIcqqrdgmw 469  human
EFA81619     1068 ---------------------lfsvsdkdsfnpllsttqpysnvihdrYSTFQEAFTFVPhDVGFMVEIKYPnllmqnl- 1125 Polysphondyli...
XP_001313062  210 --------------------------------------------yktpIPSLQEILTQVPeSSPMDIEVKAIheeirlf- 244  Trichomonas v...
XP_965976     248 -------------------------------------------kehhlPCTLSKLLDQIGnEHGINIEIKYPlpseere- 283  Encephalitozo...
XP_001580767  211 --------------------------------------------ykceRPTFKELMTDLPkDLVLDIEIKYPfsklfr-- 244  Trichomonas v...
CAL50333      452 -----------------yeddessrvtfyrvfgedpepqpwimeieddIPTLGQILSNTPdSLGFNIELKYDeens---- 510  Ostreococcus ...
XP_001693345  225 ddgsgsmvddcgatggrphskllrlfrdrstrqagtryepwacaaddsIPTLEAVFRAMPpEIGFDIEMTTGddvvh--- 301  Chlamydomonas...
XP_001768871  115 --------------------------------akdnyvsiwtatvedsLCTLQEVFEEVDqNVGFNVEVKFDdvlk---- 158  Physcomitrell...
XP_002501246  175 --------------------------------agtpepapwimdvedeIPTLDELMSVAPdDLGFSLELKFGtpedfpg- 221  Micromonas sp...
EEH54903      201 ---------teyseisqthvvfyrrfpvgygsvrapepepwvmdiegpITTLEELFNDAPkSLGFSAELKFNasnp---- 267  Micromonas pu...
Feature 1                                                                                         
Q9NPB8        470 dgnlstyfDMNLFLDIILKTVlensgkRRIVFSSFDADICTMVRQKQNkYPILFLTQGkseiy-------pelmDLRSRT 542  human
EFA81619     1126 --rkfsapERNEFVDIILNIVfneageRRIAFLTFDPDIAILLRTKQFrYPVLFLVCSdtpsfysvfdpdvnvnDSRGNS 1203 Polysphondyli...
XP_001313062  245 --nkvaypERNMFVDSVLSVIdkyigsRNIIFSTFDLMTAIMLKLKQNkFPVLQLSCVedfep-------eivgMSRLMA 315  Trichomonas v...
XP_965976     284 -hglrgliPAEKVVERIVETVqrs-grQKVIFSSFHPYVLLLLKLRLPsSNIYMLTEAnnn-----------keNPYTGT 350  Encephalitozo...
XP_001580767  245 --dkipyaERNHFLQRVIDEMnayvgdRELFFSAFCPLVVVMLATKQSrWPVYQLMTVekdet-------fekfLLKVRS 315  Trichomonas v...
CAL50333      511 ----cetrRLVAELRAILAVCfeh-pnRRIVFSSFDPDAALLMRAIQGaYPVMILTDGepd-----------hvDPRRRS 574  Ostreococcus ...
XP_001693345  302 ----tpaeEVDRMLSAILPVQqqppmgRRIMFSSFDPDVCVELRRRQSrYPVYYLSGCgly----------thaDARRTS 367  Chlamydomonas...
XP_001768871  159 ----tsddELRRVLYPILEVVkqhakgRKVYYSSFNPDAVYLLRKEQSsYPVFFLTDGgvn----------lfnDPRRNS 224  Physcomitrell...
XP_002501246  222 -gkkvdpaRMIMELRATLAVCksh-prRRVAFSTFDPDAATHMRALQGlYPVMFITNCqpg-----------qdDVRRCS 288  Micromonas sp...
EEH54903      268 ----adeeTMRGDLGAILAVCrah-ptRRMMFSSFDPDAACIMREMQDhYPVMMLSDCdag-----------atDPRRRS 331  Micromonas pu...
Feature 1                                                                                        
Q9NPB8        543 TPIAMSFAqfeNLLGINVHTEDLLr-------nPSYIQEAKa---KGLVIFCWGddtNDPENRRKLKElGVNGLIYDRI 611  human
EFA81619     1204 ILNAVSFVktvNLDGIVCDSESILq-------nHSFVKTVHq---ENLLLFTYGsknVDANNVKIQNDlGVDGIIADNL 1272 Polysphondyliu...
XP_001313062  316 CINAHKDL---GINGFVLDSELVLky------kDMATNIVN----QNYALFTYGkgnYEEKTVLEQLKmGVRGICTDFC 381  Trichomonas va...
XP_965976     351 LYDALYFSaklGLDGVVLDWNCIS---------ASPIHIVKafesFDLKTIVYGsgvNNRDVIHILNEaGVHGIILDNL 420  Encephalitozoo...
XP_001580767  316 FAPLHKEL---GINGFVLDSEHLLke------pKLATELIN----MGFQVSTYGkpnNTVEAINQQLDlGLTGICTDTM 381  Trichomonas va...
CAL50333      575 VAAAMEVAlqgGLCGVVSDVKAIMa-------nPSDALDVRd---NGLLLATYGegnDDATSSSTQVElGVYGIITDRV 643  Ostreococcus t...
XP_001693345  368 IPAALSFAveaGMRGVVMPASVLLk-------nMDTVASAGa---SRLELMTYGlenNDLGALQAQADaGVVAAIVDEV 436  Chlamydomonas ...
XP_001768871  225 IQAAVQVCeegNLQGIVTEVGAILr-------ePTLVSLVKq---VGLWLFSYGvlnNIAEVVEKQKIlGVDGVIVDHV 293  Physcomitrella...
XP_002501246  289 VEAGIKTAldaDLVGLVIRADVLRn-------dPTVPTRVRa---AGLMLGSYGgpnTDLALVERQVDlGVGYLCTDDV 357  Micromonas sp....
EEH54903      332 VAAAVDVAldnRLSGLVLNVNVLSsnggnkamdPTARSIADdvrgKGLYLGTYGkanDDAEFVVRQAEwGASYVCTDAV 410  Micromonas pus...

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