Conserved Protein Domain Family
GDPD_SHV3_plant

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cd08571: GDPD_SHV3_plant 
Glycerophosphodiester phosphodiesterase domain of glycerophosphodiester phosphodiesterase-like protein SHV3 and SHV3-like proteins
This subfamily corresponds to the glycerophosphodiester phosphodiesterase (GDPD) domain present in glycerophosphodiester phosphodiesterase (GP-GDE)-like protein SHV3 and SHV3-like proteins (SVLs), which may play an important role in cell wall organization. The prototype of this family is a glycosylphosphatidylinositol (GPI) anchored protein SHV3 encoded by shaven3 (shv3) gene from Arabidopsis thaliana. Members in this family show sequence homology to bacterial GP-GDEs (EC 3.1.4.46) that catalyze the hydrolysis of various glycerophosphodiesters, and produce sn-glycerol-3-phosphate (G3P) and the corresponding alcohols. Both, SHV3 and SVLs, have two tandemly repeated GDPD domains whose biochemical functions remain unclear. The residues essential for interactions with the substrates and calcium ions in bacterial GP-GDEs are not conserved in SHV3 and SVLs, which suggests that the function of GDPD domains in these proteins might be distinct from those in typical bacterial GP-GDEs. In addition, the two tandem repeats show low sequence similarity to each other, suggesting they have different biochemical function. Most members of this family are Arabidopsis-specific gene products. To date, SHV3 orthologues are only found in Physcomitrella patens.
Statistics
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PSSM-Id: 176513
View PSSM: cd08571
Aligned: 25 rows
Threshold Bit Score: 343.114
Threshold Setting Gi: 168007624
Created: 7-Dec-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
NP_567755     360 FLVITKDGASGDYPGCTDLAYKKAIKDg--aDVIDCSVQLSSDGTPFCLSSIDLGNSTTVsltafrnrst-tvpelgslg 436  thale cress
NP_001062173   54 PIVIAEGGFSGVFPDSSKNAYVFALSStsgdTVLWCNVQLTKDGVGICLRDLLMDNCTSIsqayragkka-ylvngeekk 132  Japanese rice
NP_188688      33 PAVIARGGFSGMFPDSSIQAYQLVNITtspdVMLWCDLQLTKDGVGICFPNLKLDNGSNVirid------------phyk 100  thale cress
EEC72640       52 PLVIARGGFSGLFPDSSQFSYQFAMSSslhdVVLYCDLQLSSDGLGFCKTGLTLENSTLIaeafpkrakt-ykvngeeih 130  Indian rice
NP_200613      41 PAVVARGGFSGLFPESSISANDLAIGTsspgFTMLCNLQMTKDGVGLCLSDIRLDNATTIssvfpkaqkt-ykvngqdlk 119  thale cress
XP_001756508   38 PLVIANGGTSGLYPDQTLRAYRDAANStsspLALLCDLMISKDNFGICRPGFFLEMSTNTtsypatakrstysgygqnlt 117  Physcomitrell...
NP_176869      50 PLVIARGGFSGLYPDSSIAAYQLATLTsvadVVLWCDLQLTKDGLGICFPDLNLANASTIdrvypnreks-ysvngvttk 128  thale cress
NP_200359      50 PLVIARGGFSGLLPDSSLDAYSFVSQTsvpgAVLWCDVQLTKDAIGLCFPDVKMMNASNIqdvypkrkts-yllngvptq 128  thale cress
ACN35879       63 PLVVARGGFSGAFPDSSEGAYSFGASAsapgTAMWCDVQLTKDGVGLCLRDVNMKNCTTVdqtypgrkrt-yvidgvhkt 141  maize
NP_001047275   40 PAIIAKGGFSGLFPDSSDFAYGFVAAAsspdTALWCDVQLTKDGAGICLPDIRMDNCTNIanvypkgkkt-ysvngvstp 118  Oryza sativa ...
NP_567755     437 AIYTFSLTWAEIQtltpaisnpyrvtslfrnpkqknagkLFSLSDFLSLAKnstslsGVLISVENAAYLreeqgldVVKA 516  thale cress
NP_001062173  133 GWFPIDYTMSSLQsviltqaiwsr-----tdkfdfaflpILPVTNVIDLAKp----sSVWLNIEHDIFYrqh--glNMTK 201  Japanese rice
NP_188688     101 ERFSVDFTWKELSdvklaqgvvs------rpyifddvssILAIEEVAKLTAs-----GLWLNIQDSAFYakh--nlSMRN 167  thale cress
EEC72640      131 GWFALDFTADELYqnvtliqdifs-----rpstfdgamgMFTLEDLVGLKPp-----HLWVNVEYALFLqeh--klSAED 198  Indian rice
NP_200613     120 GWFVIDYDADTIFnkvtlvqnifs-----rpsifdgqmsVSAVEDVLGTKPp-----KFWLSVQYDAFYmeh--klSPAE 187  thale cress
XP_001756508  118 GYFANDFTLAELLtvtgmrtsna-------rppiftqetLAAPENVSQIAAef--gvATWINVEFPEFFqeypapnSLLS 188  Physcomitrell...
NP_176869     129 GWFPNDFSLTELQnfllirgilsr-----tdrfdgngylISTIEDVVTTLNr----eGFWLNVQHDAFYeqq--nlSMSS 197  thale cress
NP_200359     129 DWFTIDFNFKDLTkvilkqgilsr-----saafdgnsygISTVKDISTQLKp----eGFWLNVQHDAFYaqh--nlSMSS 197  thale cress
ACN35879      142 GWFVPDFTSAELLqsvyltqaiws-----rtermdgiypIVTVPDVQSIVNt----sPIWLNVQHPIFYkqr--dlDMSS 210  maize
NP_001047275  119 GWFSVDYDSTGLSkvnlvqslfs------rvpyydgtlpILPVESVFANYKa----pAVWLNVQHDSFYsqf--nlSMRS 186  Oryza sativa ...
NP_567755     517 VLDTLTqtgysnstatKVMIQSTNSSVLVDFKkq------sqYETVYKVEENirdi------ldsaIEDIKKFADAVVIQ 584  thale cress
NP_001062173  202 YILSIPkg------gsVQYISSPELGFLQSISgrvnr-ktklVFRFLDATSSdpssnqtygsllsnLTFIKTVASGIMVP 274  Japanese rice
NP_188688     168 SVVSLSrr------lkVNFISSPGISFLKSMKnsvkptvtklIFRFLKQEHIepftnqsygslaknLSYIRTFSSGILVP 241  thale cress
EEC72640      199 YILGLPkd------fsVAYISSPEIGFLKNVGaklkksntklIFRFLREDVAehttkktygeilkdLKSVKAFASGILVP 272  Indian rice
NP_200613     188 YLRSLRfr-------gINVISSPEIGFLKSIGmdagraktklIFEFKDPEAVepttnkkyseiqqnLAAIKAFASGVLVP 260  thale cress
XP_001756508  189 YLTSFLkt------nkVQYLSVTNSSILKLIAptng---trlVLKLLDYDGLvdpl-------fqnLTDIATYAQGVLVP 252  Physcomitrell...
NP_176869     198 FLLSVSrt------vsIDFISSPEVNFFKKITgsfgrngptfVFQFLGKEDFepttnrtygsilsnLTFVKTFASGILVP 271  thale cress
NP_200359     198 FLLSISkt------viIDYLSSPEVNFFRNIGrrfgrngpkfVFRFLEKDDVevstnqtygslagnLTFLKTFASGVLVP 271  thale cress
ACN35879      211 YIHSIRkl------vrMDYISSPEIGFLRNISarvrr-rtklVFSFLDKKLLdhsvnqtygslarnLTFVRSVASGILVP 283  maize
NP_001047275  187 YILSVSkq------yiADYISSPEVNFLTSLSgrvnk-ktklVFRLLNELAVepstnqtygsmlknLTFIKTFASGILVP 259  Oryza sativa ...
NP_567755     585 KLSVFPva----qsFITTQTNVVEKLQKsQLPVYVELFQNEFlsqPYDFFADATVEINSYITGa--gINGTITEFPFTAA 658  thale cress
NP_001062173  275 KEYIWPvtt---nnYIQPAKSIVRDAHSaGLEIYASDFANDRi-iPYNYSYDPLEEYLHFVGSdnfsVDGVLSEFPLTAA 350  Japanese rice
NP_188688     242 KSYIWPvds---alYLQPHTSLVTDAHKeGLQVFASEFANDFv-iAYNYSYDPTAEYLSFIDNgnfsVDGFLSDFPVTPY 317  thale cress
EEC72640      273 KEYIWPlgk---dqYLRLPTSLVKDSHAlGLEVFASGFANDVs-mSYNYSFDPSAEYLQYIGNanfsVDGVITDFPPTAS 348  Indian rice
NP_200613     261 KDYIWPids---akYLKPATTFVADAHKaGLEVYASGFANDLr-tSFNYSYDPSAEYLQFVDNgqfsVDGVITDFPPTAS 336  thale cress
XP_001756508  253 NSYVIPknftgygvYEGQATTAVQDAHKaGLEIFVYGFANDRqpyIYNYSKDPVLEVLSYVGDsf-tADGIVTDFPNTAA 331  Physcomitrell...
NP_176869     272 KSYILPldd---eqYLVPHTSLVQDAHKaGLQVYVSGFANDVd-iAYNYSSDPVSEYLSFVDNgdfsVDGVLSDFPITAS 347  thale cress
NP_200359     272 KSYIWPie----sqYLLPRTSFVQDAHKaGLEVYASGFGNDFd-lAYNYSFDPLAEYLSFMDNgdfsVDGLLSDFPLTAS 346  thale cress
ACN35879      284 KDYIWPvta---dnYLLPSTSIVTEAHEaGLEIYASGFVNDKa-vPFNYSYDPLAEYLNFVGDggfsVDGVLSDYPITAS 359  maize
NP_001047275  260 KNYIWPvtq---dnYLQPSTSVVGDAHKaGLEVYAADFANDFl-lSYNYSYDPLTEYLNFIDNgafsVDGVLTDFPITPS 335  Oryza sativa ...
NP_567755     659 RY 660  thale cress
NP_001062173  351 AA 352  Japanese rice
NP_188688     318 RA 319  thale cress
EEC72640      349 GA 350  Indian rice
NP_200613     337 QS 338  thale cress
XP_001756508  332 TA 333  Physcomitrella patens subsp. patens
NP_176869     348 AA 349  thale cress
NP_200359     347 SA 348  thale cress
ACN35879      360 EA 361  maize
NP_001047275  336 EA 337  Oryza sativa Japonica Group
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