Conserved Protein Domain Family
GDPD_EcGlpQ_like_1
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cd08560: GDPD_EcGlpQ_like_1 
Glycerophosphodiester phosphodiesterase domain similar to Escherichia coli periplasmic phosphodiesterase (GlpQ) include uncharacterized proteins
This subfamily corresponds to the glycerophosphodiester phosphodiesterase domain (GDPD) present in a group of uncharacterized glycerophosphodiester phosphodiesterases (GP-GDE, EC 3.1.4.46) and their hypothetical homologs. Members in this subfamily show high sequence similarity to Escherichia coli periplasmic phosphodiesterase GlpQ, which catalyzes the Ca2+-dependent degradation of periplasmic glycerophosphodiesters to produce sn-glycerol-3-phosphate (G3P) and the corresponding alcohols.
Links
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Statistics
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PSSM-Id: 176503
Aligned: 11 rows
Threshold Bit Score: 631.379
Created: 6-Jan-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:catalytic site [active site]
Evidence:
  • Comment:The catalytic mechanism of glycerophosphodiester phosphodiesterases is based on the metal ion-dependent general acid-base reaction.
  • Comment:Based on structure evidence and site-directed mutagenesis of Thermoanaerobacter tengcongensis glycerophosphodiester phosphodiesterase, the catalytic site consists of two conserved histidine residues which serve as general acid and general base in catalyzing the hydrolysis of the 3'-5' phosphodiester bond.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                               #                                          #             
YP_002605500  56 LKKTLGDCIDGPfyr--tdFSIGHRGAS-MQFPEHTRESYEAAAAMGAGICECDVTFTRDRQLVCRHSQCDLATTTNILA 132 Desulfobacteriu...
CBF89396      52 LKKKLESCTEKPird-sssFSISHRGGP-LQFPEHSREGLYAGARMGAGLLECDVAFTSDRQLVCRHSQCDLHTTTNILL 129 Aspergillus nid...
YP_002362905  63 LKSKLKACSEKHltr--trFSISHRGAP-MQFPEHTVEGYQAAARMGAGIIECDVTFTKDRELVCRHDQCDLHTTTNILT 139 Methylocella si...
XP_001805230   6 LKHKLQSCENKPvai--sdFSIAHRGGGtLQFPEETVQSEEAGARMGAGILECDVSFTSDRGLVCRHSLCDLHTTTDILL 83  Phaeosphaeria n...
ZP_05314566   58 LKNKLESCEKGPfkr--tnFSIGHRGAP-LQFPEHTLESYEAAARMGAGIVECDVTFTQDKELVCRHSQCDLHTTTNILE 134 Nitrosomonas sp...
YP_114356     50 LKSKLLKCSEGPfrk--aeLAIGHRGAA-LQFPEHTRESYEAAARMGAGIIECDVTFTKDKELVCRHAQNDLHTTTNILT 126 Methylococcus c...
ZP_01306692   44 LKTQLRGCQNKIleh--qaFSIAHRGAP-LMFPEHGFSSYQAAHTMGAGKQECDVTFTKDGELVCRHSQCDLHQTTDVLL 120 Oceanobacter sp...
YP_580895     86 LKDELLACKGQTpsk--tdFSIAHRGAP-LQFPEHTYDSYMASAQMGAGILECDVAFTNDGELVCRHAQNDLHTTTNIVA 162 Psychrobacter c...
ZP_05705557   42 LKQELLACAQQTpkk--teFAIGHRGAA-LMFPEHTRDSYLAGAREGAGILECDVAFTKDKELVCRHAQNDLHNTTNILA 118 Cardiobacterium...
XP_002177323  44 LKDQLAMCAEDTkhyavsdFSIGHRGAC-LQFPEHTLESYAAALEMGAGIVECDVTFTKDRQLICRHSQCDLHTTTNVVT 122 Phaeodactylum t...
YP_427727     50 LKDKLESCKTGPfyk--stFSIGHRGAP-LQFPEHTRESYVAAARMGAGIVECDVTFTKDRQLVCRHSQCDLHTTTDILA 126 Rhodospirillum ...

Feature 1                                                                                        
YP_002605500 133 VPeLAAKCSEPFTPavfdpetgklikpASAKCCTSDITLGEFKRLkGKMDASNPSATTve--aFMDATPSWRTDLYta-- 208 Desulfobacteriu...
CBF89396     130 IPeLAAKCTTPFQPata-------dseATAKCCTSDITHEEFLSLcAKMDTSNPNATTpe--eYQYGGPDWRTSTYdn-- 198 Aspergillus nid...
YP_002362905 140 IPaLAAKCTQPFTPang-------gtpASATCCTSDITLAEFRLLkGKMDGFNPNATTpe--eYQNGTPSWRTEAYsa-- 208 Methylocella si...
XP_001805230  84 RPeLAKKCSQPFTPana-------tspANALCCTSDITMAEFSTLcGKQDGFNASATTpl--aYQAGTPNWRTELYdt-- 152 Phaeosphaeria n...
ZP_05314566  135 TP-LAEKCSVPFQPavldaa-gnlitpAVAQCCTSDITLAEFKSLqGKMDAANPRATSvt--gYLKGTADWRTDLYat-- 208 Nitrosomonas sp...
YP_114356    127 IPeLAAKCTRPFTPatfdas-gnlltpASAECRTTDITLAEFKMLrGKMDAFNPRAKTpv--eFQGGTPDWRTNLYagpt 203 Methylococcus c...
ZP_01306692  121 RPeLAKQCYQPFVPane-------sqpAQANCCTSDFTLKQLKQLcIKMDGYNSSAVTae--eFVKGTPSWRTDLFqt-- 189 Oceanobacter sp...
YP_580895    163 TP-LANQCSVPPIIdangt----ltnaADIECRTSDISVRDFKSLtGKMDAANPKATSis--aYMNATAPWRTDLYsq-- 233 Psychrobacter c...
ZP_05705557  119 TP-LAAKCSVPFKPaefdad-gklvkeAEVECRTTDITLAEFKSLkGKMDGGNKEARTve--eYMNGTPDWRTNLYaq-- 192 Cardiobacterium...
XP_002177323 123 IPdLNAKCTTPWSAg------------VSPNCCASDFTLDEIKTLcAKMDSSGPSEAAtaeeyAYGGTADWRTDLYqles 190 Phaeodactylum t...
YP_427727    127 HPdLAQKCTEPFTPadaa-----sgkkASAKCCTSDITLAEFKTLsGKMDASDPTATTia--aYMNATPKWRTDLYat-- 197 Rhodospirillum ...

Feature 1                                                                                        
YP_002605500 209 rGTLMTHAESIELFKr--lGMKMTPELKAPDVTMPFDGn----YTQAKYAQQMIDEYKKAGIapDQVFPQSFNlgDVIYW 282 Desulfobacteriu...
CBF89396     199 cATTIDHKTYIQITDs--lGLQFTPELKTPEVEMPFQGn----YTQEMYAQQLIDEYKQAGIspKRVWPQSFLedDIFYW 272 Aspergillus nid...
YP_002362905 209 tGTLVTLKEHIALMNs--fGVNMTPELKEARVPMPYQGd----FTQEKYAQKMIDAYKAAGVspKRVWAQSFNinDIYYW 282 Methylocella si...
XP_001805230 153 cGKVLTLNQYIDFVDaqpgYRNFTPELKTPPFPMPYKG-----YTQQQYAQDFIDAFRAKGVscDRVWPQSFTydDIVYW 227 Phaeosphaeria n...
ZP_05314566  209 rGTLLTHKESIALFQk--lGVKMTPELKSPSVPMPFDG-----FSQADYAQKLIDEYKEAGVrsSKVWAQSFDlaDVLYW 281 Nitrosomonas sp...
YP_114356    204 sGTLMTHKESIALFKk--lGVKMTPELKSPVVSMPFDG-----FSQEDYAQKMIDEYKEALVpaSKVFAQSFNkaDVLYW 276 Methylococcus c...
ZP_01306692  190 cEQIVTHKESIKLFSe--wDVDMVPELKTPQVEMPFSLnketaFTQQRYAQKLVNEYKEAKInpEKVWLQSFDlkDIRYW 267 Oceanobacter sp...
YP_580895    234 nGEVLTLKEHIALASs--lGMKHTPELKEPVVTMPFNG-----YSLDTYRQQLIDTYKVAGVpaSDVYPQSFNlaDIDYW 306 Psychrobacter c...
ZP_05705557  193 nGELMTHKESIELFKq--lGVKMTPELKEPVVPMPFDG-----FTLEDYAQKMLDDYTAAGVpaSDVYPQSFQpeVIRYW 265 Cardiobacterium...
XP_002177323 191 cPEVPTHKESIAFIKa--gNGYFTPELKSPSVEMPYEGn----YTQEMYAQQMIDEYVEAGVppEQVWPQSFSpdDVFYW 264 Phaeodactylum t...
YP_427727    198 hGTLMTHAESIALFKs--lGVGFTPELKSPSVAMPFEGs----YSQSDYASQMINDYSAAGIdpAQVHAQSFDenDVYFW 271 Rhodospirillum ...

Feature 1                                                                                        
YP_002605500 283 LKNDPqFGRQAVYLDgrdgdknfdi----trpdtwsptMDELFAQNVRIIAPPMWMLLaid--knGKIVPSTYAKRAKAa 356 Desulfobacteriu...
CBF89396     273 IKAEPsFGKQAVYLDprvdtqag--------yeaavssMNKLYKQGVRILAPPIFALLngt--asGEIVPSSYAKAAKKa 342 Aspergillus nid...
YP_002362905 283 IKNEPaFGKQAVALAetdvpad---------lppaiaaLPGMRAKGVQIVAPPIWALIald--gsGKIVPSAYANAIKQn 351 Methylocella si...
XP_001805230 228 LKNDHdFGRQAIYLQefdtped---------iaagmknLSIARAAGVNIIGPSIPMLVspg--pnNTIVPSEYAKAIKAn 296 Phaeosphaeria n...
ZP_05314566  282 IQHEPdFGRQAVYLDgryddpafdh----rnpatwspaMTQLVADGVKIIAPPMWMLLei---enGGIVPSRYAKAAKDa 354 Nitrosomonas sp...
YP_114356    277 IQHEPaFGRQAVYLDdaeevad----------lpgaaeLAQYKADGINIVAPPIFALLdvd--aaGNIVASEYARNVRRa 344 Methylococcus c...
ZP_01306692  268 LKNEPeFAKQAVYLDgryvdpqfde----nkpstwqpsMKQLKELGLHYIAPPLWVLMke---egNEIVPSEYAIHAKQa 340 Oceanobacter sp...
YP_580895    307 INNEPnYATNAVYLIddsnesaagkifdkndpttwkhsLAELKARGVNIIAPATWLLVtsd--gnGKLLPSAYALQAKAn 384 Psychrobacter c...
ZP_05705557  266 LKNGGeFAKQAVFLDetldta------------prikeMPEWRKAGLNYLSPAMPMLVkd---egGKLVPSDYAKAAKDn 330 Cardiobacterium...
XP_002177323 265 IDNTE-FGAQAVALDdqydlnt----------tdveafLDLLVSRNVKIVAPPMQRLVdpapdseYLMTASHYANAAKNr 333 Phaeodactylum t...
YP_427727    272 AEKFPdFARNAVYLDdrdetkgfsp----mdpaswsptMEELVAKGVKVIGPPLWYLVtld--adNRIVPSVYAKRAREa 345 Rhodospirillum ...

Feature 1                                                                                       
YP_002605500 357 GLDIITWTLERSGLLk---tGGGWYYQTIkda----------innDGDMLVALDVLAQEVGILGIFSDWPATVTFYANC 422 Desulfobacterium...
CBF89396     343 GFDLITWSLERSGPLkqaaaEGEYYVSTIadv----------ikgDGDMYRIVDALARKVGVMSIFSDWPATVTYYANC 411 Aspergillus nidu...
YP_002362905 352 GFKIIPWSLERSGPLt---dGGGYYYQSVssv----------ikgPGDYYNVLDVLSSKVGILGIFSDWPGTATYYGNC 417 Methylocella sil...
XP_001805230 297 GMDIIAWTFERSGPLatvksRKEYYFESIanv----------tsyDGQYYVLLDVLANQIGIKGLFSDWSATVTYFANC 365 Phaeosphaeria no...
ZP_05314566  355 GLDIITWTFERDGPLt---nGGDWYFQTLngqnpnpvspdavinnDGDMYQALDVLAQDIGILGIFSDWPATVTYYANC 430 Nitrosomonas sp....
YP_114356    345 GLDIITWTLERSGILa---dGNNGFYYQTfdsa---------iyrEGDMMRVLDVLARDVGIRGIFSDWPATVTYYANC 411 Methylococcus ca...
ZP_01306692  341 GLKLIAWTLERSNNMe---qGGGWYYQTIqnk----------vnsQGDIFVVLDVLARQVGVHAVFSDWPATTTYYANC 406 Oceanobacter sp....
YP_580895    385 GLDILTWSLERSGPLk---sGGGWYYGGLsda----------innDGDIMNVIDVLAQEVGVKGIFSDWPATVSYYANC 450 Psychrobacter cr...
ZP_05705557  331 GFKLITWTLERSGPLa---rGGGWYFTGIenh----------akkDGDTYKYLDVLAKDVGISGIFSDWPATVTYYANC 396 Cardiobacterium ...
XP_002177323 334 SLGVIAWTLERSGPG-----LTGFYWETLedqv---------elnEGDRYNLLHVLLNEVEVLGVFSDWPATTTFFANC 398 Phaeodactylum tr...
YP_427727    346 GLAIVTWSLERSGPLa---tGGGWYYSSItka----------vnsDGAMMTLLDVLAKDVGVIGVFSDWPATTTYYASC 411 Rhodospirillum r...

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