Conserved Protein Domain Family
Cyt_b561

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cd08554: Cyt_b561 
Eukaryotic cytochrome b(561)
Cytochrome b(561) is a family of endosomal or secretory vesicle-specific electron transport proteins. They are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments. This is an exclusively eukaryotic family. Members of the prokaryotic cytochrome b561 family are not deemed homologous.
Statistics
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PSSM-Id: 176489
View PSSM: cd08554
Aligned: 42 rows
Threshold Bit Score: 61.5303
Threshold Setting Gi: 121992303
Created: 19-Nov-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative heme
Feature 1:putative heme binding sites [chemical binding site]
Evidence:
  • Comment:four conserved histidines may be involved in heme coordination

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         #                                                       #                   
Q8NBI2     43 MFNWHPVLMVAGMVVFYGGASLvyrlpq--------------------swvgpKLPWKLLHAALHL-MAFVLTVVGLVAV 101 human
Q8I6E3     32 SSGQHALYAILGLFLCVGESLLvchsww-------------------lgdfisENRLNLLHMVLGM-VGLWLGLVGIFAK 91  fruit fly
Q29CM0     57 RTAEHAFYCVLGLFLAVGEALLfrhsww-------------------lvrmigMPSLELMHSTLGL-LGFWSGCIGVLPK 116 Drosophila pseudoo...
Q9VIT5     91 GTGLHAWLVTIGFSFFMAEGVMihygg----------------------nvltNGYKRQTKTTIHWvLLTLGGGCGAAGA 148 fruit fly
Q9VIT6     45 GIRLHAWLVTFGFVFLMAEGMMcfydgsw------------------ltvrysRNYKTAFHVVLQI-LGGGMGVAGCLIQ 105 fruit fly
EDW05666   52 ISNVIVILVTVIIAYKCAKLRLtrtaahafycl---------vgmvlfvtqafLLASPALHASFGL-VGVLIGFVGVGAQ 121 Drosophila mojavensis
EDW81939   79 RTGEHAFYCTLAFVSFTSESLIishcww-------------------mldligKRNCDLVHIALGL-MALCIGLLGISVE 138 Drosophila willistoni
EDV34928   59 GTAEHAYYCTLGLFLCVGECLLmtntww-------------------mrrlftHRGLLRTHMGLGM-LCLWPGFIGILMK 118 Drosophila ananassae
EDV99707   44 MVISHILFIAITIAISRKCLLLqlartakhaf-----------ycavaqvlcvSEAMMIRNALMHTtFGLLGCLLGFFGV 112 Drosophila grimshawi
EDW57990   34 DFYFHISEVIANFMFIVITVLIsrkclilrlqrtaehvfyctlaqmlsvaetlMLRNLLLHTIFGM-MCFVVGFFGVGLQ 112 Drosophila virilis
Feature 1                              #                                       #              
Q8NBI2    102 Ftfhn----------hgrTANLYSLHSWLGITTVFLFACQWFLGFAVFLLPwasmw-lrsllKPIHVFFGAAILSLSIAS 170 human
Q8I6E3     92 Sifks----------kihEPHFNSKHGLCGLLGFLLIAGAVASGFALVCFThlal----hviHRLMGLCGFVLLSCSQWF 157 fruit fly
Q29CM0    117 LrqwselkrrhghtscisIKHCLTKHGLCGLMGLLLTLGCLLSGLALLGIRnvsl----hwsHRILGLSGFFCSICSQWF 192 Drosophila pseudoo...
Q9VIT5    149 Likm-----------iqkGFLLQSTHGRLGMTAFVLCILAMSSGLAALFSSrikklitpllnKTFHNFLGFACFVIALVT 217 fruit fly
Q9VIT6    106 Lir-------------ddWSISVTLHARLGFAAFVLCLISLLSGLVAFLARclsrtisplvnKTFHVVLSFTAFVIAMMA 172 fruit fly
EDW05666  122 Ilhmr----------anaQKHFTTNHSIFGLATCFLLLATLITGLYPSCQPlarms--einaLFAHRICGLLSFVLLMTS 189 Drosophila mojavensis
EDW81939  139 IyrrrfkslkhlqtkvnpPVVHLTTHGALGFGGCILSAVCLATGVALLFFSnlpl----hltHRFCGLLGFVVLMFCQWH 214 Drosophila willistoni
EDV34928  119 Cinkvkqn---ameeeqyESHCTSKHSLCGLLGYFLLVGALGTGLSLVWYSemal----hltHRLLGLSGFTTLACSLWF 191 Drosophila ananassae
EDV99707  113 Gtev-----------lrkQTHFRSKHGRFGLAGCLLLFGSFFTGMWLLLQQlrnef--sislLFGHRVCGLFCFMATMGT 179 Drosophila grimshawi
EDW57990  113 Illkhk-------rargtRRHFRSSHSIFGLAGCLLMSVSFFTGICLLLYPmrkqv--cisvLFVHRVCGLFCFIILMAS 183 Drosophila virilis
Feature 1          
Q8NBI2    171 VISGI 175 human
Q8I6E3    158 ALNLG 162 fruit fly
Q29CM0    193 AFNSG 197 Drosophila pseudoobscura
Q9VIT5    218 QYYGY 222 fruit fly
Q9VIT6    173 QFYGY 177 fruit fly
EDW05666  190 LIFSF 194 Drosophila mojavensis
EDW81939  215 AYNTE 219 Drosophila willistoni
EDV34928  192 SFNTG 196 Drosophila ananassae
EDV99707  180 LMFSY 184 Drosophila grimshawi
EDW57990  184 FMFSY 188 Drosophila virilis

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