1SV0


Conserved Protein Domain Family
SAM_PNT-Mae

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cd08536: SAM_PNT-Mae 
Click on image for an interactive view with Cn3D
Sterile alpha motif (SAM)/Pointed domain of Mae protein homolog
Mae (Modulator of the Activity of ETS) subfamily represents a group of SAM Pointed monodomain proteins. SAM Pointed domain is a protein-protein interaction domain. It can interact with other SAM pointed domains forming head-to-tail heterodimers and also provides a kinase docking site. For example, in Drosophila Mae is required for facilitating phosphorylation of the Yan factor and for blocking phosphorylation of the ETS-2 regulator. Mae interacts with the SAM Pointed domains of Yan and ETS-2. Binding enhances access of the kinase to the Yan phosphorylation site by providing a kinase docking site, or inhibits phosphorylation of ETS-2 by blocking its docking site. This type of factors participates in regulation of kinase signaling particularly during embryogenesis.
Statistics
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PSSM-Id: 176086
View PSSM: cd08536
Aligned: 10 rows
Threshold Bit Score: 106.644
Threshold Setting Gi: 198429711
Created: 29-Jan-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
heterodimer
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface ML
Evidence:
  • Structure:1SV0; Drosophila melanogaster, Mae (SAM_PNT domain)/Yan (SAM_PNT domain) dimer, contacts at 4A
    View structure with Cn3D
  • Comment:The mid-loop (ML) surface of Mae SAM_PNT interacts with the end-helix (EH) surface of Yan SAM_PNT.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             ##                        # ### ##  #    #   #                  
1SV0_C        10 DPRDWTRADVWKWLINMAVSEGLEVtaeLPQKFPMNGKALCLMSLDMYLCRVPV-GGKMLYRDFRVRLA 77  fruit fly
XP_001622734   1 DPRLWSKWDVLEWLKWATERYNVKDv--AADKFLMNGKGICMLPPEGFVYRVPR-GGDVLYNDFHKRLK 66  starlet sea anemone
XP_001637300   4 DPRLWTREDVTSWLRWISEAYSLENv--KLDRFEMNGKALCLMTLDMFLYRVPE-GGRVLYHDFQRRLR 69  starlet sea anemone
XP_002128427  57 DPMRWTEIHVMTWVRDISVLFQFNV---DLNLFVMNGKGICLMSLEGFRYRSPV-GGALLYNDLQHKLL 121 Ciona intestinalis
XP_002415932   4 DPRQWSREHVAVWLVHVMAQHQLPAv--SPDRFLMNGKALCLMNMEMFVQRVPL-GGKLLYKDFQLRLS 69  black-legged tick
XP_002605904  41 DPLSWDLRDVRTWLRHLAARHQITV---DLRLFHMNGRGMCLMNLQGFEYRVPV-NGHILYEDFWRRVA 105 Florida lancelet
NP_001034488  35 DPRQWTREHVAQWINLVTQQHGLPEv--PSSRFLMNGKALCLMSLGMFLSRVPL-GGKLLYKDFQLRLC 100 red flour beetle
XP_002608220 286 DPRSWSREDVRTWLEWAQTHYTVGEl--DAGKFIMNGKGLCLMDKKGFVYRVPG-KGEVLYLDFQERLF 351 Florida lancelet
XP_001175615 116 DPRKWAALHVGRWLEAVSAKYALQV---NKTDFVMNGRALCLMKREGFLDRVPE-NGAILFEDFRRRLR 180 purple urchin
XP_002595957 489 DPFTWSPWHVKWWVYAMSRVYSLSV---VLPMFEMNGRGLCLLSLPGFMYREQTgKGYLLYYDLRYRLW 554 Florida lancelet

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