2O7I,1VR5,1ZTY


Conserved Protein Domain Family
PBP2_TmCBP_oligosaccharides_like

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cd08509: PBP2_TmCBP_oligosaccharides_like 
Click on image for an interactive view with Cn3D
The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold.
This family represents the substrate-binding domain of a cellulose-binding protein from the hyperthermophilic bacterium Thermotoga maritima (TmCBP) and its closest related proteins. TmCBP binds a variety of lengths of beta-1,4-linked glucose oligomers, ranging from two sugar rings (cellobiose) to five (cellopentose). TmCBP is structurally homologous to domains I and III of the ATP-binding cassette (ABC)-type oligopeptide-binding proteins and thus belongs to the type 2 periplasmic binding fold protein (PBP2) superfamily. The type 2 periplasmic binding proteins are soluble ligand-binding components of ABC or tripartite ATP-independent transporters and chemotaxis systems. Members of the PBP2 superfamily function in uptake of a variety of metabolites in bacteria such as amino acids, carbohydrate, ions, and polyamines. Ligands are then transported across the cytoplasmic membrane energized by ATP hydrolysis or electrochemical ion gradient. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.
Statistics
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PSSM-Id: 173874
View PSSM: cd08509
Aligned: 85 rows
Threshold Bit Score: 263.799
Threshold Setting Gi: 15922868
Created: 27-May-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
substrate
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:substrate binding site [chemical binding site]
Evidence:
  • Structure:2O7I_A; Thermophilic cellulose binding protein from Thermotoga maritima (TmCBP) binds cellobiose, contact at 4 A.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             #                                                                          
2O7I_A        10 TVYIGGalwg------patTWNLYApq-----sTWGTDqf---mYLPAFQYDlgrDAWIPVIAERYEFvd---------- 65  Thermotoga mari...
NP_343997     38 TLYLGWynsnve-ayssfaTYNPNIfagglggsFYGLLy----aYSAIINVSn--SQAIPVIITSWNFspanwqq--iwq 108 Sulfolobus solf...
YP_001540515  50 TIYVFTisspp---ltsmsLYNPNIfhg--giaWYGVV------QSHVAAINyttGEEIPILAKNWTLqvlp-------- 110 Caldivirga maqu...
NP_344363     55 TFGVTTgsgp-----ivpnNWNVFGvgersddiPYEFI------FETLGIADfmtGQVYPWLATNWTFtdn--------- 114 Sulfolobus solf...
YP_002844308  39 SLVVVAntig-----twqdNFNPWNs-------PYSSYdgewfiYEPLALIDygtSQIIPWLATNWTFtntttyvn-dkp 105 Sulfolobus isla...
NP_344354     38 SMVIMPspgi-----vwqdNFNPWNap----alPGGLIwl---iYEPLALVNslsGQIIPWLATNWTFttgyvnlpngtk 105 Sulfolobus solf...
NP_394785     52 TLYLSPgptp-----aftdNFNPFDgvw---ltPAGIMgl---iYEPLLQINtynGTVIPWLATGYSWnsn--------- 111 Thermoplasma ac...
NP_378537     44 VLTIGWvtssp---ytslsSYNPNIfsgglggaFYGLVy----aYSAILNVSn--NQMLPGIVENWTFspsnwvqe-fns 113 Sulfolobus toko...
YP_001541308  43 TIYMFVtrspp---atgwsTYNPNIfqg--giwWYGVY------QQFLAAVNittGEFVPLLADNWTMtvlp-------- 103 Caldivirga maqu...
YP_001541239  27 TFTVINaesstyiyapgipVFNPYTps-----nLVGVVs----tWVPLAFYNpvtNHFWPILAENWTIqvlp-------- 89  Caldivirga maqu...
Feature 1                                                                                        
2O7I_A        66 --dkTLRIYIRPe--ARWSD----GVP------ITADDFVYALELTKElgigpggg--wdtyieyVKAVD--TKVVEFKa 127 Thermotoga mari...
NP_343997    109 tkpvNVTLIIRNd--SGWSN----GQP------LTAYDLMATCLILDMfgap---------pfpnYTVIN--NYTLVETw 165 Sulfolobus solf...
YP_001540515 111 ngtlAIYVTLRQ---SGMSN----GQP------VTCWDLLANNIANGLihnm----------wgnVSIVN--NYTCIFKm 165 Caldivirga maqu...
NP_344363    115 --ntNFIVYLRHgvyFYYNGtlpnGTQgqilwpFSAKDVVATYQDYFKvygnp--------fnvtVTEVN--PYEVIFHf 182 Sulfolobus solf...
YP_002844308 106 aptfGIVLWLRHg--VYFTD----GTP------FNATAVWYTFALEQAypqlgyt----andianMTIINpyEIEIVFNq 169 Sulfolobus isla...
NP_344354    106 vqtlALILYLRHd--VYFTD----GTP------FNATAVWYTLALEQAypqlgys----anqianMTIINpyELEIVFKp 169 Sulfolobus solf...
NP_394785    112 --atILTMYLRHg--VEFSN----GLP------FNASDVVYTFNEQKAlfgew-------gviknITAVN--PYEVNFTf 168 Thermoplasma ac...
NP_378537    114 lssvNVTLYLNPn--AHWAN----GQP------VTAYDILATCLILDMysap---------pfpnYTVIN--NYTITISy 170 Sulfolobus toko...
YP_001541308 104 ngtlEVLVHLRH---SGWDN----GIP------VTCWDVWATNMLLGLvsam----------vgnVTVFN--NYTCAFMi 158 Caldivirga maqu...
YP_001541239  90 ngsgILTVYLRRg--LYWFN----GSAvm---pFTAWDVYTYFYIGVKafkwyypymlpqyadedIRVLD--NYTIQFLf 158 Caldivirga maqu...
Feature 1                                                                                        
2O7I_A       128 keen-----------lnyfQFLSYslg-----------------aqPMPKHVYeriraqmnik----------------- 162 Thermotoga mari...
NP_343997    166 ppdtls-------pilftdTLINTvglg--------------evaiIIPYQVWkpiisqimgnwttiqntsnmklaqqii 224 Sulfolobus solf...
YP_001540515 166 pqgyyapptspaaeaydvfWALNWggvalvwtf----nawyplmeaTLANYSWlwlfnfgnatqqaqark---------v 232 Caldivirga maqu...
NP_344363    183 gkp-------------nvqYALYDlle-----------------qfIVPWEQYanltnpa-------------------- 212 Sulfolobus solf...
YP_002844308 170 ratpai-------lytilgHFIVDpaqwgk-----------lfpiqQLPNGTYvalnktgn------------------- 212 Sulfolobus isla...
NP_344354    170 gvtp-----------mvlyTILEQwpvdpaqw-------gkifpveQLPNGTYvglnktgn------------------- 212 Sulfolobus solf...
NP_394785    169 tspn-----------teylFYIGSn--------------------iIVPEQLFanstdpl-------------------- 197 Thermoplasma ac...
NP_378537    171 pkdyvs-------pylmpfTLLDTvglg--------------evavITNYQVWkpiitqiegnwtllqegkvk---ttvf 226 Sulfolobus toko...
YP_001541308 159 pkgyyvpl--tlpgaheanSFIALewgqgialdwqdsyvwepiiktAAANYSWiwlymfgnstqkgeaakv--------l 228 Caldivirga maqu...
YP_001541239 159 qkws----------ptewiFLLASq--------------------iSTPYSVWepivdklktmnvtq------------- 195 Caldivirga maqu...
Feature 1                                                                                        
2O7I_A       163 -------dwindkpeeQVVSGPYKLYYYDPNIVVYQRVDDWWgkd------ifgLPRPKYLAHVIYkdnp----saslAF 225 Thermotoga mari...
NP_343997    225 knirseilhfrpnpatYPYSGPFYLSQLSSNEIVLNKNPYYYda--------kyIPFNQVIIYQYGqadl-----aaaAI 291 Sulfolobus solf...
YP_001540515 233 ltplinelftaklppnTPTTGPFYVCDITPEYILLCKNPYWYda---------kDIKVDYIVEWQYssmt----qvyaAL 299 Caldivirga maqu...
NP_344363    213 ----------aavipiPVGTGPYYLAKATETQATFYRNPYYWip---------gRPFISTFTYYVGisna----qaygLL 269 Sulfolobus solf...
YP_002844308 213 --------pftypnpnPIGTGPYMLYSFSAQQIVLVANPHYWmp---------gEPRIKYLLFPAYasss----qaatDL 271 Sulfolobus isla...
NP_344354    213 --------pftypntnPIGTGPYMLYSFSPQEIVLVANPHYWmp---------gEPRIKYLLYPSYpsnv----qadtAL 271 Sulfolobus solf...
NP_394785    198 ----------keivtnPIGTGPYVLQSFSPQKIVLTANPNYWqk---------gEPKIKTVVYVEYtsns----altlAM 254 Thermoplasma ac...
NP_378537    227 rsmirsfnpalvasisADYNGPFYVSQITPSEIVLSKNPGFYaa--------nmVPWNEVIIYQYTssqd-----llaGV 293 Sulfolobus toko...
YP_001541308 229 stlihdyltykppyttGYSNGPYYLCDITPEYFLLCKNPYYYtv---------nEFKPDYIVEWQYssms----qvyaAL 295 Caldivirga maqu...
YP_001541239 196 --takystnvtefvppYWGLSPYYLTFISTNTVVEKLEPMYFngkpllaiwdelFPFNTFNYYPEVesvypggntqdlAL 273 Caldivirga maqu...
Feature 1                    #                                                                   
2O7I_A       226 ERGd----iDWNGlfipsvwel-wekkglpvGTWykkepyFIPDg------VGFVYVNnt----kpGLSDPAVRKAIAYA 290 Thermotoga mari...
NP_343997    292 TGGqv--smDWSGltglspt-----qleslpTTLev--inIPQPf------GWGIAFNlk----npWLREYQVRAAIAYI 352 Sulfolobus solf...
YP_001540515 300 ASGki---sIWRTggssisst---llsqilrNPYiem-niYPGFg------GDALYFNfl----npWLAMPQVRQAIYYA 362 Caldivirga maqu...
NP_344363    270 AKGi----aQWGGtgstgstpfsklftyanpQYYh----gMASIgngsggqPSFLWINfarl-nywPWNETWFRYALSLA 340 Sulfolobus solf...
YP_002844308 272 SLGk----iQWAGlsiqdiqsv-fvaknpqyNHYf-----FQHVt-----sPGVLYLNdm----rwPLSDPILRQAISLA 332 Sulfolobus isla...
NP_344354    272 NNGq----iTWAGlfepniqqqfvakdplhyHYYf-----APGF-------PTMLTLNnl----kwPLSDPVLRQAISLA 331 Sulfolobus solf...
NP_394785    255 QSGq----vQWASvfapnittlfvsknpqynHYW------FPQGq------PVTLLLNdm----vyPLNMSFFRQAISVA 314 Thermoplasma ac...
NP_378537    294 KTGe----iDLLYtgatslps---lalsslpSSYkv--isIPQPg------GYGLYFNlq----npWLKYVQVRQAIAYI 354 Sulfolobus toko...
YP_001541308 296 ATGkislwsTWIGsvsptv------iptitsNPYika-lsFPAFg------GDALYFNfl----npWLAMPQVRQAIYYA 358 Caldivirga maqu...
YP_001541239 274 EIAgk---aNWAYvglssqq-----ietamqHGFkni-nlYAWS-------TYAIAINaynfptnnMWLNLKFRQALLWV 337 Caldivirga maqu...
Feature 1                                                                                        
2O7I_A       291 IPYNEMLKKAYf-GYGSQahpsmvidl---------fepykqyidYELAKktfgte----------dgripFDLDMANKI 350 Thermotoga mari...
NP_343997    353 LNRTAIASVGG--PLTAPvt------------------------iPNAIPnlsyysfmtssqyysslnpynVNLTKAAQL 406 Sulfolobus solf...
YP_001540515 363 VNWTQLAQAAYgpQFILPsptpqvg--------------imndmyPSLVQqvigywasq----gsplinytYNPSMATQL 424 Caldivirga maqu...
NP_344363    341 LNRTQISLGSQy-GIPTGapptp------------------adflPSPMEeiwlnstii----qeahqvdqYNLTEAIQI 397 Sulfolobus solf...
YP_002844308 333 INRTAITYLVYy-NYTTPai-----------------------dlPVSVGqlgffnstvi-qlaqelappqGNVTAALQL 387 Sulfolobus isla...
NP_344354    332 INRTAIYYLGEy-GYEPPattp-------------------lplpPQQLQyinssvlql----aeqfappqGNVTAALQL 387 Sulfolobus solf...
NP_394785    315 INRTAIMNIGEy-GYEQPanaaglly------------qqlgelnSTNLAlank--------------latFNLTYAKQI 367 Thermoplasma ac...
NP_378537    355 INRTAVALVGG--AKYSPvh------------------------vPNGIPnfsyfnefrt-pavsnlnpynVNLTKAAEL 407 Sulfolobus toko...
YP_001541308 359 VNWTQLAQAAYgvGYTYPspmpqdglmpyytnwqsmitsyfaslgPQWTMvn-----------------ytYNASLATSL 421 Caldivirga maqu...
YP_001541239 338 LNRTEMAAAWGlpGVPNSswilplwrni-------pspdyilstyPQPIQnmvyd-----------ymtytVNWTKAAEI 399 Caldivirga maqu...
Feature 1                                                                                        
2O7I_A       351 LDEAGYKk-gPDGVRVGPDGtklgPYTISVPy---gWTDWMMMCEMIAKNLRSIGIDVKTEfp-dFSVWADRMTKgt--- 422 Thermotoga mari...
NP_343997    407 LKSVGFYq--KSGVWYTPNGt---PFTLTIGag-spPTQALAMMEEVQKELQQFGINVQLHiytvVSQWHQAWQNgtgyd 480 Sulfolobus solf...
YP_001540515 425 LESAGFTe--KNGVWYTPNGse-fTLTLYISsg--aSPPQLALANSIANALTSFGIPTTVTvy-pSSEFSTIVQQgky-- 496 Caldivirga maqu...
NP_344363    398 LESHGLKi--INGKLSFPNGtplpTYTMINYq---gFSDTYATTQLIAEDLAQIGLQINVVse-tPSQMFAALDGgq--- 468 Sulfolobus solf...
YP_002844308 388 LESHGYKl--INGQLIAPNGtpvpTMTIEAPa---gSTVWDAEVNLYAQQLKQIGLNVQVV----IPPFSTALNDl---- 454 Sulfolobus isla...
NP_344354    388 LESHGYKl--VNGQLITPNGtavpAMTIITVa---gWTDWDADLTLIAQDLKQIGITVEVQtp-pFTTWYNYMETgn--- 458 Sulfolobus solf...
NP_394785    368 LADHGFIinsTTGRLTAPNGtpvpTLNLMSVa---gYSDWDTDIALIANELNQLGLTVNLEtp-tQNTVSQDVTDgqyqm 443 Thermoplasma ac...
NP_378537    408 LESVGFTe--KNGQWYTPAGt---PFTLNITdtissSPGVTSMLTLIADELTSFGIPTTYSvs-tIASINHQLYKsgd-- 479 Sulfolobus toko...
YP_001541308 422 LESVGFTk--KNGVWYTPNGse-fTLTLYIGsn--aPPAQLTLATEIANALTSFGIPTIVIty-pSAEGLTIIKQg---- 491 Caldivirga maqu...
YP_001541239 400 LESAGFYe--KNGQWYTPGGqp-iKMTLMMPa---qFTNQVAAVSNAAEQFSIFGIPTTTLae-dVATYSSHILItgdyq 472 Caldivirga maqu...
Feature 1                        #                                                               
2O7I_A       423 ----------fdLIISWSvgpsf--------dhpfnIYRFVLdkrlskpvge------------vtwagdwerYDNDEVV 472 Thermotoga mari...
NP_343997    481 lwfenwgssyspGTAPWSlvlsyfg----gypwnvtQWNENLtl---------------------------pnGTIIDFH 529 Sulfolobus solf...
YP_001540515 497 ----------dlIFLYYDgapepgfpsffpegpipaAYFQGYpfnathwn---------------mvvtlpngTQVTPLQ 551 Caldivirga maqu...
NP_344363    469 -----------yDLIYWItnay----------spyyVWESAFipplipgtdqpnvtaletigvyvysdfgrwiPPKEFID 527 Sulfolobus solf...
YP_002844308 455 -----------lSGNFWMermylls----tgptpimFFQAFLynpvntpgnitpig---nstiynvgrlnlslRLSPNSP 516 Sulfolobus isla...
NP_344354    459 ----------ywMGLMWDlisgptpiq-plsgylygYWNSPGnitpignsty------------ynierfnlsIIHPTFE 515 Sulfolobus solf...
NP_394785    444 al----yvdtgiGPNAWY------------------DYSGLVgpvvkass----------------payvnpeRWNATGT 485 Thermoplasma ac...
NP_378537    480 ---------yglVFQAWGg-----------------YYPGTVdwylqlqylsgi-------pynvthwdllvpLPNGSVY 526 Sulfolobus toko...
YP_001541308 492 -----------kYDLLFS------------------YYSDIYrpgvpyyfp-------------eafyflgypFNYSHWN 529 Caldivirga maqu...
YP_001541239 473 aad-yfgpglvsYYTGWS------------------MWVNPFdsnlfint----------------slpypfqWPNGTCT 517 Caldivirga maqu...
Feature 1                                                                 #                      
2O7I_A       473 ELLDKAvs----tlDPEVRKQAYFRIQQIIYRd--------MPSIPAFYTa-----hWYEYSTk------YWINWPSEDN 529 Thermotoga mari...
NP_343997    530 KLLEETes----pnTTQQLIQANQELSYYMNQy-------lLPILPLVEIe-----nYVIVNPslliaapPANSWIWEEA 593 Sulfolobus solf...
YP_001540515 552 ACTDYLl-------SPARIFSCYAISMWAWNHy--------TPFIQIDRNt------WIFFLNt------QYINWPLNDT 604 Caldivirga maqu...
NP_344363    528 LWIQAGdt-----tNVTLLKQIYNNMAAILIKd--------LPAIPVVFDay----pRYEYEDq------YYIGFSTPQY 584 Sulfolobus solf...
YP_002844308 517 PIIKLYqyamgnisNVAEYEKLLNEIGMFWLKy--------MPAIVLING-------WVNYEYin----sSISGWVTPQH 577 Sulfolobus isla...
NP_344354    516 QLVNWAngn--fsiNDNAYYSIVNKLAALWIKy--------MPSIALVYGa-----eWYEYVNn------TVTGWPTQQN 574 Sulfolobus solf...
NP_394785    486 GFMQYFhnft-altNTTQQDVYINKMASIMLQq--------MPIVYVVYSa-----dWYEYVNs------TIGGWPNAQN 545 Thermoplasma ac...
NP_378537    527 NMSKLYve----stAPNSTSQLIAANDEIAYAln-----yyLPVLPLVYTd-----yVIVYNSnvi-sapPSSSWFWEEA 591 Sulfolobus toko...
YP_001541308 530 GIVTLPngts-fsaPECGTMLSLNCILRVAWA---------INHDPWYIQidw-nsgIVFLNT-------QYINWPINDT 591 Caldivirga maqu...
YP_001541239 518 PVTLSLpm-----pNSTIVTCINSTLGWINITnaeyafysaVPGSPQYEEavevlfaWWNYFV-------PQLEWGEKLE 585 Caldivirga maqu...
Feature 1          
2O7I_A       530 PA 531 Thermotoga maritima
NP_343997    594 QY 595 Sulfolobus solfataricus P2
YP_001540515 605 SI 606 Caldivirga maquilingensis IC-167
NP_344363    585 FY 586 Sulfolobus solfataricus P2
YP_002844308 578 NY 579 Sulfolobus islandicus M.16.27
NP_344354    575 YY 576 Sulfolobus solfataricus P2
NP_394785    546 PF 547 Thermoplasma acidophilum DSM 1728
NP_378537    592 LY 593 Sulfolobus tokodaii str. 7
YP_001541308 592 SI 593 Caldivirga maquilingensis IC-167
YP_001541239 586 PQ 587 Caldivirga maquilingensis IC-167

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