Conserved Protein Domain Family
PBP2_SgrR_like

?
cd08507: PBP2_SgrR_like 
The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold.
A novel family of SgrR transcriptional regulator contains a two-domain structure with an N terminal DNA-binding domain of the winged helix family and a C-terminal solute-binding domain. The C-terminal domain shows strong homology with the ABC-type oligopeptide-binding protein family, a member of the type 2 periplasmic-binding fold protein (PBP2) superfamily that also includes the C-terminal substrate-binding domain of LysR-type transcriptional regulators. SgrR (SugaR transport-related Regulator) is negatively autoregulated and activates transcription of divergent operon SgrS, which encodes a small RNA required for recovery from glucose-phosphate stress. Hence, the small RNA SgrS and SgrR, the transcription factor that controls sgrS expression, are both required for recovery from glucose-phosphate stress. Most of periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.
Statistics
?
PSSM-Id: 173872
View PSSM: cd08507
Aligned: 32 rows
Threshold Bit Score: 392.018
Threshold Setting Gi: 116618922
Created: 27-May-2009
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
A1JJG7       116 RQGKHILRVLYYRPLq-nLLPGTAlRRSETHMVRQIFNGLTRINeenGELEPDLSHHWQAISPl-HWRFYLRPAIHFHHG 193 Yersinia entero...
YP_002769592 132 KRSQEILRIPRERAFs-tIDPAFVaVAAESHFIQQICHTLVIFDlatQDFKPQLAYAWERNLDmtAWTFYLRKGVRFHHG 210 Brevibacillus b...
YP_002773968 141 VSHQDILRFPVYRRIv-tLDPGLVyYHFDAHLVGQIFNTLVQYDlnsRSILPSIAHSWESSPDarKWTFYLKKNVLFHHG 219 Brevibacillus b...
YP_002773518 131 KGRVDTLRLFYSRPFa-gLDPIHIlLRSESHMVKQLFDSLVQFDpvtRRIEPAIAFYWESSEEgkQWTFYLRKGVLFHHG 209 Brevibacillus b...
ZP_02850359  128 EDCRDALIFPVLKAPv-tLDPADLlYSFDSHLIRQISDRLLRYDeqlDKIVPMLAHNWTSNADatEWTFYLRKGIRFHNG 206 Paenibacillus s...
ZP_01860542  117 NQHRDVLRMKYGKQPftpLDPMLAsLRSECHILKHVCDTLVSYNeekNLFEPRLSFHWEHNEEgdQWTFYIRKGVKFHDG 196 Bacillus sp. SG-1
NP_830645    121 NDMYDILKIPISRKIf-pLDPAFVaVTTESHLTSQIFDTLVVYNdvtEKMEPHIAHTWELSEDglTWTFYLRKDVYFHNE 199 Bacillus cereus...
ZP_02845549  127 GKEADVLRLPIFKTIm-tLDPADFvYSLCSHMIQQIFDRLVLLDestGQIKPGIAHYWEHNEDatVWTFHLRKGILFHGG 205 Paenibacillus s...
ZP_03227665   44 HAQKDILRTIIARKLt-tLDPIFSsITFESFLIGQLGDPLVTYNkemDKIEPRIAHHWKSNDShtLWTFYIRKGIQFHDH 122 Bacillus coahui...
O07570       128 NGAKDVLRLFITPESvssLDPCQIfLRSEGHFVKQIFDTLFTFDsdmQEPKPHLVHGWEEVGKk-QWRFFLRKGVLFHNG 206 Bacillus subtil...
A1JJG7       194 RELEMNDVITSLTRLIPq-------PLFSHITAVRSPTPYVIDVHLSAPDnWLPWLLGSVHAMILPQEwenqp--dfrrh 264 Yersinia entero...
YP_002769592 211 RVLTGEDVTYTVQRLIQlds--pyrWQVDDIDWIEQRNDGAITFHLRKPNgFFLHLVSCIGMSILPHDvlfs-----esa 283 Brevibacillus b...
YP_002773968 220 RELTAHDVVFSLNRLRLypdtyeasWMFRDIDQLIAIDDRTVRILLKEPNyLLLRLLATIPASIVPEEivwqdekgfgek 299 Brevibacillus b...
YP_002773518 210 RPLVADDVRFSFLRLMEhsy--khrWLAASIESITVKDEYVITISLHMPDeLFLQALSKEYMAIVPADyvlemgeqfaqm 287 Brevibacillus b...
ZP_02850359  207 QELTSRDVRFTLERLQHdta---nsWLLREVTCVEAVSSRVLRIRLKKANrIFDRFMCSAAASIIPYEfagmdeeefwrq 283 Paenibacillus s...
ZP_01860542  197 KRLTAEDIQFTFIRFLSfekn-pyrWMLEDLEEAVIVNEQSIMLKLKRPNfLLLHILSDEHLSIVSKDeqkef---yaet 272 Bacillus sp. SG-1
NP_830645    200 TVLTSKDVQFSFERLKEvhs--pfeWLTEEIVQIETPSPLQIRFHLAKPNlFFLHYVSSMQLAILPRDtsiq-----nhh 272 Bacillus cereus...
ZP_02845549  206 HELAAADVVFTAERLRNggk--rnsWIMRSLEQVEAVSERIVRFHLSRPNwLFLKYAASNVMAILPANmlglseeqfwkl 283 Paenibacillus s...
ZP_03227665  123 STLTTQDIEYTFNRFKAvdn--aysWVVEHIDRMNLLSDYTIEFYLKEQNpLFLRFISIANFSILPHHisfd-----eke 195 Bacillus coahui...
O07570       207 QPLTSRDVAFTFQRFLEladn-pykWLLHGVKQVLEKGPYCVELILDKPNaLLPYALCDERLSILPAEqg--------gg 277 Bacillus subtil...
A1JJG7       265 PIGTGPYSVIRNHQSQLKIQAFDNYFGfRALIDEVNIWVl--PELSEELVYSg----------------------VQLQA 320 Yersinia entero...
YP_002769592 284 IVGTGPFRMVEFTEDRLVLAAFDDYYReRAILDRVEIWRv-pGSCSSKQRYQ-----------------------LSLAE 339 Brevibacillus b...
YP_002773968 300 PIGTGPFQLVRLTEGICILEAFPAHFLgRPQLDRVEILIf--PELETGRLKEpnwasvmvshgvqskaqalreavIQDGQ 377 Brevibacillus b...
YP_002773518 288 PVGTGPFRVVRNDDSMLVLEAFMPYFGgRPFLDRIEIWCv--PGMAAEAQAAdesll--------------svtaLDDHR 351 Brevibacillus b...
ZP_02850359  284 PIGTGPFQLAKWANGRIKLEVNDVYFQgRPYLDEVEVVIm-pEDCGNDLDKLtkvhh--------------sldtMRMDK 348 Paenibacillus s...
ZP_01860542  273 LIGTGPFKLVRNDGSMLIMEANDHYFReRPFLDAVEFWNv--PEEREDRTPGkt--------------------eVEFGY 330 Bacillus sp. SG-1
NP_830645    273 YIGTGPFKLAHYSEDNIVLEAFTHYFKeRALLDRIEFWGi-pDHVQIDADYE-----------------------LPNEE 328 Bacillus cereus...
ZP_02845549  284 PSGTGPFQIEEWKDGKLLLGANPHYYLsRAHLDQVEIVHvpqEEAIKAGMTSwqqlic-----------dptlrdVTVEN 352 Paenibacillus s...
ZP_03227665  196 WVGSGAFRLKENSNQKIVLSAFDSYFLeRPILDEVQFVRv-dHSALHNVTFH-----------------------LENEE 251 Bacillus coahui...
O07570       278 KNGTGPFQMNQQHSGMLVLEANERYFKgRPYLDRVEFVFs--EQAGEMNGFT-----------------------IQEKQ 332 Bacillus subtil...
A1JJG7       321 Ddts-----knELESRLEe-GCYFLLFDQRSpl-tRNPDIRRWLCELITPVALLSHADpfyq-------rywsPAYGMLp 386 Yersinia entero...
YP_002769592 340 Deat----eddSKSLEVQevGCHYLNFNFRKpgiqHDFAFRQAIKLLIDPVQMIRDLKket----------ftPAGSFLp 405 Brevibacillus b...
YP_002773968 378 Dw--------cDTEAFFS--CCNLLVFNQWKsgphNHFKFRQALDLLIDRDQMIADLGgdr----------iyPAKGFRt 437 Brevibacillus b...
YP_002773518 352 Etsf----lawSDVGRLEd-CFQYVSMNGAKngplSHREFRSLVVAIICGQNLRQELQgtreyaviwgktdsfQEQRKVp 426 Brevibacillus b...
ZP_02850359  349 Smtk----ddwQQIGKLCp-GCVLMSWNVAVdrpqQSAAFRHAVSKIIRPGEMIMELGger----------alPAYGFRp 413 Paenibacillus s...
ZP_01860542  331 SrdrsgegkkrKRDKRVEk-NVQFLSLNAKNev-mRDPFLRQALKAIADPSVLVGELGefr----------qeTADGFLn 398 Bacillus sp. SG-1
NP_830645    329 En--------eRHDIQIEeiGCIYASFNFTKpgphHDIYFRKAWRELYDVETILRSIEgrr----------tiAASSFFp 390 Bacillus cereus...
ZP_02845549  353 Gw--------iQIESRSL--CTSLLSWNMKKagpqRSETFRRIVNRLIDRHAMIRELSgyr----------dfPARGFFp 412 Paenibacillus s...
ZP_03227665  252 Eqi------qlQKTKEIEv-GYRFLVFNFHRsaivNDAKFREAIYHLLDMKRMWRDLDrdh----------lvEASGNFy 314 Bacillus coahui...
O07570       333 Tc--------pEQQTVFDerHVQYLSLNLKKkgplQHRSFRKALRLLISSERLVREAGghr----------riPVTSFLh 394 Bacillus subtil...
A1JJG7       387 r--------------wHHNRLRVLETKPEGLt-ELTLTFYSHHsefDAISQTLTKLLADQGVNLKIHvv------dYTQW 445 Yersinia entero...
YP_002769592 406 ersqr-----mhfsshTIEEAAHWLQKSAYQg-EAVLLSFNDTkkvREEAEWLHERCQRVGIRLELQgitkgqflsYDTA 479 Brevibacillus b...
YP_002773968 438 yhpvlrevrareneqpCHAQIMSLLQESDYQgeTLRLVTTAYH---EEDALWIQQRCGEYGIHLAVDv--------REPW 506 Brevibacillus b...
YP_002773518 427 ----------------GSQEFVRIFKESGYQgeALSLYTYPDSd-hIEDAQWIQKTCKAYGIAIEIR---------YASP 480 Brevibacillus b...
ZP_02850359  414 easct-----qtlepiQPEQIRKLLQESGYCgeILRIAFHSKY---NDDGRWVIDRLAEWGIQLEMLp--------YGDA 477 Paenibacillus s...
ZP_01860542  399 rp-----------sdsGTADIKNLLKKSKYNgeELRLYTFQDRd-hLEDADWLKQRALKFGVILKNIfl------pAEEL 460 Bacillus sp. SG-1
NP_830645    391 ersrq-----askraySLEKAKEYLKKSTYNgeTIHIYFFAFKd-sANDAYFLKERCESLGIQVELHpf------lVSDY 458 Bacillus cereus...
ZP_02845549  413 elmtvh---epdkdslEPEEASRLLVEAGYAgePMSLCAHPGH---AEDVDWIANRCRRAGILVEVRie-----apYRIH 481 Paenibacillus s...
ZP_03227665  315 wnse--------erdrSFEKVRELIEESSYEgeTLRVYQLNKEh-aIEEANWFMEAGKKVGIQLELHlfql--dsfYTED 383 Bacillus coahui...
O07570       395 psp----------fewEGVSPSELLKKSGYEgeTIVLYTFSETd-hREDAEWIQNICAQHGIRLTLQfc------dAADL 457 Bacillus subtil...
A1JJG7       446 YQGDAQs-------DMWLGSANFylp---------lefSLFATLYelpllqy---------cldeelHQDVELWRNNTl- 499 Yersinia entero...
YP_002769592 480 QHADMAmmgevlqrDIELGLMEIykn----------kcSLVHRFLdddrla-----------iveerMSKILQLQDSKer 538 Brevibacillus b...
YP_002773968 507 EFSNRDclp---ehDCQLYGNVFssd----------qiSELEMYLqrnyf-------------lpafDESLALAINKEig 560 Brevibacillus b...
YP_002773518 481 EELASPsll--qeaDFVVDSANVder---------aelSLREFLHagalsis--------hhldphgKEEIAYWMNRLsc 541 Brevibacillus b...
ZP_02850359  478 LQADVCi------sGLVFPEDEVceiea-----yehrdCVMQSYFdkenkawi------lsridaavGAESKQQRRQQ-- 538 Paenibacillus s...
ZP_01860542  461 LKEETMee-----aDIIHDSATIteq---------eelSFLQLIFakanpvwhhlp-gelkdsimteVNHLKGISNPQer 525 Bacillus sp. SG-1
NP_830645    459 MNRSIDqh-----aDIIFMGEVFaad---------helAFLNVFKnkscfinrfmdphyekqincllDTFLLEENKEKry 524 Bacillus cereus...
ZP_02845549  482 HVLDEI--------DLLFHALVFpeedvsliegceqdgSFLKELM----------------------SAELSRWTMESfd 531 Paenibacillus s...
ZP_03227665  384 FEQYAD--------FIFMGEVSSsdh----------hvSFYGSFKnkallfrrm----llpshlgkiDSYLNQFKMESst 441 Bacillus coahui...
O07570       458 RRPEIVqm-----aDIIHDSATFyqd---------sefGFLHLLLs--------------------eNSFLYQHLSEKlt 503 Bacillus subtil...
A1JJG7       500 ---------------------qMADWSQRLVSQNQFHPLFHHWLELYGQhsMRGVRMNTLGWFDFKSAWFT 549 Yersinia enterocolitica ...
YP_002769592 539 m-------------------raLEKMEDILKDEAWLLFLYHTKRFDHYHpaLQGIAVDSFGWIDFSKLWVK 590 Brevibacillus brevis NBR...
YP_002773968 561 ltfqep--------drlarehhLARIEAMIKENYAVLYLVQKRTLASFHksLRGVSINSSGWLDFHKIWFQ 623 Brevibacillus brevis NBR...
YP_002773518 542 arta------------qdrqacVDSIMHTLAACNTFVPLYSNRVEMLAHprLSGVSLDAYGWIDFRRIFVR 600 Brevibacillus brevis NBR...
ZP_02850359  539 ----------------------LREIEERLREEALVLFLHHRRLSTYLHpsVRGVSLNPLGWIDFKDIWLE 587 Paenibacillus sp. JDR-2
ZP_01860542  526 m-------------------krLYSIEEMLLNSCQVLPLYKNMSEMESDesIQQALINSQGWIDFYRIWFK 577 Bacillus sp. SG-1
NP_830645    525 --------------------elMYEVEEFLQTEHIILFNYHVLKRKTYPssLKNVTIDSFGWANFAKLWIQ 575 Bacillus cereus ATCC 14579
ZP_02845549  532 qalase--------dpasrkaiYTAIEERLKGEAQVHFVLHMKFHTDYHpsLKGVRINSLGWIDFKDIFRT 594 Paenibacillus sp. JDR-2
ZP_03227665  442 ak----------------reeiINEIESYIKRENLILYMHHPIKQQTFHpmIQDIQFDSFGYVDLRRLWVG 496 Bacillus coahuilensis m4-4
O07570       504 qicsgmtermfsmpdrcsriniLRDIDRQMIQELNAIPLYQNVLQVTSSknVKGLVLDEEGWIDLYSVWLS 574 Bacillus subtilis subsp....
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap