2GRV


Conserved Protein Domain Family
PBP2_Lpqw

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cd08501: PBP2_Lpqw 
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The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold.
LpqW is one of key players in synthesis and transport of the unique components of the mycobacterial cell wall which is a complex structure rich in two related lipoglycans, the phosphatidylinositol mannosides (PIMs) and lipoarabinomannans (LAMs). Lpqw is a highly conserved lipoprotein that transport intermediates from a pathway for mature PIMs production into a pathway for LAMs biosynthesis, thus controlling the relative abundance of these two essential components of cell wall. LpqW is thought to have been adapted by the cell-wall biosynthesis machinery of mycobacteria and other closely related pathogens, evolving to play an important role in PIMs/LAMs biosynthesis. Most of periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the LpqW protein. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.
Statistics
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PSSM-Id: 173866
View PSSM: cd08501
Aligned: 51 rows
Threshold Bit Score: 302.342
Threshold Setting Gi: 183982136
Created: 27-May-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2GRV_A        49 QIIMAIdsigpgFNPHLlsdqspvNAAIAslvLPSSFRPVpdptsptgSRWELDt--tLLESAEVtqe------------ 114 Mycobacterium s...
ZP_03392845   62 EVTVGVdefvegFNPHLladvspvTSLVArltLPSVFTPApveg-evgDATASAqapgVVDNAANarsagapqwllnsdl 140 Corynebacterium...
ZP_03978489   60 EIRVGAqplrggLNPHLlsddtsvVQSIAdltLPSAYLNGe------pNRDVVLg--aAVRPTSPaa------------- 118 Corynebacterium...
ZP_03933813   36 TVAIGVdplssgLNPHLvannnelVSQIAelvLPSAFHGEh------mDTDVLAsa-eEVQPPEGva------------- 95  Corynebacterium...
NP_939332     49 EIAVGIdpinggLNPHMladdstfVRSLAtlvLPSSYIGGe------lNSDLLE----SVDDVPPpsgs----------- 107 Corynebacterium...
ZP_03712102   56 ELALGIdpvhsgFNPHLladdsrfIQTLArltLPSIFVDGr------lNTDLVV----MVEELNRngevvsvtnaqhpeg 125 Corynebacterium...
YP_251189     52 EITVGVdrftgnLNPHLvgnrnpvVAAVAdltLPSVYTESs------lGEALNDd---LISEVKPnnre----------- 111 Corynebacterium...
YP_001800053  46 EINIGVdefdgnLNPHIvgnlgqsTMAVAdltLPSAFNRVg-------NRWVMNk--dLLVKVDAdnpe----------- 105 Corynebacterium...
ZP_03931653   69 TISIGVdplragLNPHLvannselVDQIAelvLPSTFHWGr------mDTDVLEsa-aEVTAPEGva------------- 128 Corynebacterium...
ZP_03918192   56 QITVGIdaikagFNPHLradesafTQSLAalvLPSAFIDGe------mNADLLV----SAEPVEPvge------------ 113 Corynebacterium...
2GRV_A       115 ------------------------------------npfTVTYKIRPeAQWTDNAPIAADDYWYLWRQMVSqpgvvdpag 158 Mycobacterium s...
ZP_03392845  141 ldsvqvlesddskdgdagngagswkaadvditdptvaaeHVRYRIRKgAQWSDGTPISGEDFRYLHSQVTStpgsldtat 220 Corynebacterium...
ZP_03978489  119 --------------------------------------mTVRYVINPeAQWSDGTPLTGADFTYLWRGMSTtagaidpag 160 Corynebacterium...
ZP_03933813   96 --------------------------------------qRVVYKIASpAQWSDGTPISGSDFHYLWTQMTStagvsdaaa 137 Corynebacterium...
NP_939332    108 -----------------------------------kavqTIRYKIRPeAQWSDATPITVSDFEYLWHAIVEtpgtlgapy 152 Corynebacterium...
ZP_03712102  126 htsqsvsaar----ptststtakpadsndaetdkpapvkTVRYRLASgAQWSDGTPITVADFEYLWSSMLNtpgtlnpag 201 Corynebacterium...
YP_251189    112 ------------------------------------nptEVVFTLQQeAQWSDGTPITISDFQYLHKAILDeplaeakgl 155 Corynebacterium...
YP_001800053 106 ------------------------------------aptEVTYTLRPhAQWSDGTPISGSDFQYLWDELRTqriaenaaq 149 Corynebacterium...
ZP_03931653  129 --------------------------------------qRVRYVIATpAQWSDGTPISGADFNYLWKKMITtagvkdpag 170 Corynebacterium...
ZP_03918192  114 ------------------------------------vkqTIRYVIAPaAQWSDGTPITGADFRYLWENMVStpgvigaag 157 Corynebacterium...
2GRV_A       159 ydlitgVQSVEg-GKQAVVTfsqpypAWRELFndILPAHivkdipggfgaglaramPVTGGQFRVETIDPqrDEILLARN 237 Mycobacterium s...
ZP_03392845  221 yeliksIDVSDg-GRQIDVTftqpitHWQRLFahLLPAHlmrsntdgfseglasrfPASGGQYTVESMDVgrNIIRLVRN 299 Corynebacterium...
ZP_03978489  161 ylavsnVRVSGpaGKTVDVDfstrveDWQSLFnyLLPSHllaadasdfataahdglPASGGRFMLQSVDRgrGTITLNRN 240 Corynebacterium...
ZP_03933813  138 yyaikeVNTSSa-GRVVTVDfservaDWHSLFahLLPSHllqdaeft--raladgiPASAGRYSVAGVDRgrGVITLNRN 214 Corynebacterium...
NP_939332    153 yraigqIRSADg-GRTVDVDlaqplhDWRVLFnnLLPSHvlrggdsdfstvladgiPASAGRYSFAGVDRqrGIVTLNRN 231 Corynebacterium...
ZP_03712102  202 ywaitdIRSSGg-GKTIEVDfnkdiaEWRTLFdhILPSHvlrgvsfa--talsstiPVSAGKFTMKSYDRnrGLITLNRN 278 Corynebacterium...
YP_251189    156 yrhitsIEPEKk-EKSFKVTfdrplsTWKRLFthLLPSHiyraegrsfgtmmdggsVASAGQYSVKSVDEgrGLLELQRN 234 Corynebacterium...
YP_001800053 150 yskisaIKVSGg-GSKVRVRfsepqeGWRQLFrhLLPSHiyraegqqfatmmdeqsVASGGAYRVHSVDAgrGVIELQRN 228 Corynebacterium...
ZP_03931653  171 yraisaVTTSDg-GRVVTVDfaervkDWKQLFnqLLPSHllqnsdfd--salandiPASAGRFSVDSVDRsrGVITLNRN 247 Corynebacterium...
ZP_03918192  158 yqaisgIRVLDg-GKTVEVDfshpyvQWKQLFdnMLPSHlfvndtvpfnqvlissiPASAGKYMLKTVDRgrGVVTLNRN 236 Corynebacterium...
2GRV_A       238 DRFWSv-PAKPDLVLFRRggapaALADSIRNGdtQVAQvhggAATFAQLsaipdvRTARIVTprVMQLTLRaqqpkLADP 316 Mycobacterium s...
ZP_03392845  300 DRYWGeqPAASEVITLRAvrsaiDGAEQLRSKqiQAVQvrptETSELTYglvpgvAEFFHEPnrELVFSTNlassrLADE 379 Corynebacterium...
ZP_03978489  241 DRFWGdnPARVDVLTINAvrdttQIADQLRSGqlGFVDtipqETTREVFglipgtETRLVDGprTLGLTLSttsplLSSE 320 Corynebacterium...
ZP_03933813  215 DRFWGadPALVDVVQLRTvrntgQAVNMLRSGqvGFVDftpeQTSLENLsllsnvNAGTVTRgrQLRLHLSarqsaLPDE 294 Corynebacterium...
NP_939332    232 DRFWGekPATVENIKFREvtdiaQGRELLRTGqiKFLDitptEVAREAFelmpntQVRTTTTslNLQLIANt----HLTL 307 Corynebacterium...
ZP_03712102  279 DRFWGkePALVENLNFREirstdQGIELIQNGqiSFMDvtptETSKEAYslvpgtQVRTETDkyGLEIVANs----HLPK 354 Corynebacterium...
YP_251189    235 DRYWGpkAAKTDIIRFTAvpnesTGAQMMRTEqiQMYMthrsATTDLALnqlpytQMRNTARgvQLNLQLNqaspiFADR 314 Corynebacterium...
YP_001800053 229 DRYWGsaPAATDKLILRAvpdvhTGAQMLRSRqlQMYAaypaGLAALTLgevpdvRGTQRDRkvQLNFALNldserMNEL 308 Corynebacterium...
ZP_03931653  248 DRFWGadPAHIDVVQLREvrdstQALNMLRSGqiGFADftpdQTSQEALgllghvSDKTVTRprQLRLHMSteqgaLEDA 327 Corynebacterium...
ZP_03918192  237 DRYWGahPAEVDILAFQEvr--dRTYQLMRSGavSYSDvapeETTVDVAtlmnetQVRVRDReaRLSLVFNmdspaITTP 314 Corynebacterium...
2GRV_A       317 QVRKAILGLIDVDLLASVGAgddNTVTLaqaqvrspsdpgyvptappaMTRDDALELLRDAGYvsepvpppdntaddppp 396 Mycobacterium s...
ZP_03392845  380 SVRRAILSTINVAEVSEVATg--RRIAGgp-----------------gDGGDQEKPEAPQAGFte--------------- 425 Corynebacterium...
ZP_03978489  321 DARKELRSLVDVPLLARLAAgrsSELAVad----------------hrPPSDQAPSVLPARVTed--------------- 369 Corynebacterium...
ZP_03933813  295 RQRRALASLIETDQVARLAAgraSELRPgqn---------------pvSGDVELAPLRERAGRk---------------- 343 Corynebacterium...
NP_939332    308 EQRADLQSLIDVHTVARIAMgrsTDLGVg------------------dQPYEPHADHLMSLGR----------------- 352 Corynebacterium...
ZP_03712102  355 PLRKELRSIIDPGLITRIAYnrrTDLTLvdkpggtit---gsgmsletTTEAAEPTVTGETGAtgtgetpentt------ 425 Corynebacterium...
YP_251189    315 ETRRRVLGAIDAEKIARIVS---GDPAVeep--------------rwnVAPKTAAEMPRDLQSeer-------------- 363 Corynebacterium...
YP_001800053 309 AVRRAALSAIKPGTVAQIVSg-kRAVTPp------------------eWGEQPVERMPDDARGlfd-------------- 355 Corynebacterium...
ZP_03931653  328 AARRGLASLIDTGQVARLATgraSNLKAghn---------------pvSGEANLTALRERASKk---------------- 376 Corynebacterium...
ZP_03918192  315 EQRTVVANAMDPHLLAKIALgrsSHLHVfd----------------pmKRNPHVEEKPDSVGTdfv-------------- 364 Corynebacterium...
2GRV_A       397 dngrerivkdgvplTIVLGVAsnDPTSVAVANTAADQLRNVGIDASVLaldPVALYGDALVnnrVDAVVGWRqaggdlat 476 Mycobacterium s...
ZP_03392845  426 ------------dnPLRIGIIsdGIAARAAAFAVADQLTAAGIPATVVsysPADMLRSSLPygtIDAVVAWAeqpn-svq 492 Corynebacterium...
ZP_03978489  370 -------------rPLRIAADaaDPEASAAARSLADLLVQRGVAARVVstdTLSVVTTGLPsgsVDVFVHWElapa-nln 435 Corynebacterium...
ZP_03933813  344 --------------PLRIAADptNSEAMAAARTIVDVLEAQAIGAEVVserTQTITGTLLPrgeVDALVSWEslav-kpa 408 Corynebacterium...
NP_939332    353 --------------PVRIGVDpsDPEAQMAARVLSDVLARKSVKTQLVetdTTDLIGSKLAasaVDAIITWSa------a 412 Corynebacterium...
ZP_03712102  426 ----dpiglqtlnrPLIIGVDpsDPVVASAAKTLVNSLIRHGVRVTMKsadTNELMQTLIPrgqVDAVVAKSg------a 495 Corynebacterium...
YP_251189    364 ------------pdGIVIAAVtdDQVAVDAARSIVDQLLHAGIPATVRtddAGEILGSSVEkgeIDGVVTWQr------- 424 Corynebacterium...
YP_001800053 356 ------------erPFTIAAPnnDKQAAIAARTIADELSRNGINAQALtvdSENLLEKMIPegeVDASVLWGrtpd-tpt 422 Corynebacterium...
ZP_03931653  377 --------------PIRFAVDptSPTALAAANTLYDILEAHGIPAEVTtdrLTTITSKLLPegkVDAVVTWEditl-tsl 441 Corynebacterium...
ZP_03918192  365 ------------stRIDVAADsrDSQAATLAQAVVDTLNNKGFVAKLVqgdPQTTQADIFV---AWERTGDSi------- 422 Corynebacterium...
2GRV_A       477 VLASRYgcraleatpvatavpgpatttsqapttttttt-----------------------------------ppatttp 521 Mycobacterium s...
ZP_03392845  493 AARERYactegsvsslppkdldeagaesaseseseaesesedvdsstkpapsgdrkesaeeqssldrttsseqsksstsa 572 Corynebacterium...
ZP_03978489  436 DAASRIacppqdyr------------------------------------------------------------------ 449 Corynebacterium...
ZP_03933813  409 TMASHFlceeagmv------------------------------------------------------------------ 422 Corynebacterium...
NP_939332    413 NAMEKLqcaptpt------------------------------------------------------------------- 425 Corynebacterium...
ZP_03712102  496 NLADSYacpnigll------------------------------------------------------------------ 509 Corynebacterium...
YP_251189    425 SPQATFdyveqygcttasekegsaapsddadlk--------------------------------------------apa 460 Corynebacterium...
YP_001800053 423 DVANQFscvqpevlrqaeeraaednashedgksdestssiapsers-------------------tesasqsasqesrrs 483 Corynebacterium...
ZP_03931653  442 SAANIFncaedepl------------------------------------------------------------------ 455 Corynebacterium...
ZP_03918192  423 AQISRYqcdsps-------------------------------------------------------------------- 434 Corynebacterium...
2GRV_A       522 tptapipapesgelvqapsnitgiCDRSIQPRIDAAl-dGTDDIADVIQAVEPRLWNm-ATVLPILQDttIVAAGP-SVQ 598 Mycobacterium s...
ZP_03392845  573 epadlngvpvapksaarsenlsglCDPQVDELLAPDssaMPAELADIVAGHSIELTLvkDGLLTVVSPeiTITGRKdSSQ 652 Corynebacterium...
ZP_03978489  450 -----------------sgnlaglCSPETDDLAGDIl-tGAYPLGDARNLVDDVLNSq-AVWVPLLHErrVLAIRS-GIV 509 Corynebacterium...
ZP_03933813  423 -----------------fsdfsgfCPENSEATVSEIl-sGRISPEEGLERVRKLNAEq-VLYVPLMDEvrIHALGR-GIV 482 Corynebacterium...
NP_939332    426 -----------------nvnialwCDPDTDQHINDVl-sGAMTREDFNSYAADVDHQqhLTTVIAPDTrlLVLGTQpEGK 487 Corynebacterium...
ZP_03712102  510 -----------------gsnrsgfCQADTQILINEYl-tGKKTEDELTEHLAHLETDeaLRTVIAIDTrlEVLGTG-VTG 570 Corynebacterium...
YP_251189    461 egsdsgdkgaslsnipkggnlsgtCDRDLEERLNKLs-eGRAELNDEREKLDERIAEi-SMVLPILSDrfTVVTSD-RLN 537 Corynebacterium...
YP_001800053 484 eptsstepveasqqrtfganitglCEPAIDEAIAEVr--DGQDSAAAIEQVNALVQSq-SVLLPLLRDeqYYAANP-EFV 559 Corynebacterium...
ZP_03931653  456 -----------------agdlsgfCPDNAAETRMDIl--SGKISPSTALGRIREINAqdVLYVPLLDEtrVHALGE-GIV 515 Corynebacterium...
ZP_03918192  435 -------------------nlsgfCDERVDFAFRQF---MTGERASVEEKVDQIERNq-VVSVPIVADtrVDILTP-QIT 490 Corynebacterium...
2GRV_A       599 NV 600 Mycobacterium smegmatis
ZP_03392845  653 WT 654 Corynebacterium amycolatum SK46
ZP_03978489  510 GP 511 Corynebacterium lipophiloflavum DSM 44291
ZP_03933813  483 GP 484 Corynebacterium striatum ATCC 6940
NP_939332    488 GT 489 Corynebacterium diphtheriae NCTC 13129
ZP_03712102  571 PD 572 Corynebacterium matruchotii ATCC 33806
YP_251189    538 GP 539 Corynebacterium jeikeium K411
YP_001800053 560 GS 561 Corynebacterium urealyticum DSM 7109
ZP_03931653  516 GP 517 Corynebacterium accolens ATCC 49725
ZP_03918192  491 TP 492 Corynebacterium glucuronalyticum ATCC 51867
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