Conserved Protein Domain Family
PBP2_LTTR_aromatics_like_2

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cd08448: PBP2_LTTR_aromatics_like_2 
The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold.
This CD represents the substrate binding domain of an uncharacterized LysR-type regulator similar to CbnR which is involved in the regulation of chlorocatechol breakdown. The transcription of the genes encoding enzymes involved in such degradation is regulated and expression of these enzymes is enhanced by inducers, which are either an intermediate in the metabolic pathway or compounds to be degraded. This substrate-binding domain shows significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.
Statistics
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PSSM-Id: 176139
View PSSM: cd08448
Aligned: 16 rows
Threshold Bit Score: 271.833
Threshold Setting Gi: 33597300
Created: 2-Oct-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putativeputative
Feature 1:putative substrate binding pocket [chemical binding site]
Evidence:
  • Comment:based on sequeuce similarity to CatM from Acinetobacter baylyi ADP1

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1              #                                                #                        
YP_299625     92 RLRVGFVGSmlyRGLPQHLRDFQAGYPgIHVALTElnsqeQIDALLHNeLDAGFVHtgrlpdeLSAVLIHSePFVCCVPQ 171 Ralstonia eutro...
NP_887585     96 VLCVGFFASmlyRGLDRAVDRFRATYPtVDLQLLElstsdQIPALLRRhIHYGFVHstrlpaeIAAGELLRePFLLCLPE 175 Bordetella bron...
NP_252284     92 QLRVGFVNSmlyRGLPRAMSRFEREHPnMEVVLGEmnsaeQAQALQRGqIDLGFVHwgrlpaeIVSEPLISdPFLCCLPA 171 Pseudomonas aer...
NP_885770     94 RLRIGFVGSmlyRGLPDLLAALRAELPdVEQVLAErnshdQLEALRRGeLDLGFIHanpppegVSARDLVAePFVVCLPD 173 Bordetella para...
YP_968561     92 RLDIGFTGSmvyRDMPAIVRAFGERAPgIEVHLREmssgeQTEALLHRqLHAGFINasvvpapLRCLPLAHdHFVACLPQ 171 Acidovorax aven...
EAR16048      90 EIRIGFLGSamqEVIPRLLLELDSRYPdIRTSLEElsnqaQVRALLQErLDLGFVRlsdlppdLEGCPVIReTFSLVVPE 169 Robiginitalea b...
NP_887532     92 SLRVGFVGAsllSPMARVLRQFEQDRPgLMLSVHElnsfeQIHALQREqIDFGIMHprsipdgILARLLHRePFVCALPD 171 Bordetella bron...
YP_003091611  96 ELRIGFLGSavqKIVPELVLGLNKEYPgIQTILDEmpnkmQIELLEKDkLDLGFVRlhrlpegISRHLVQQeTFSLVLPK 175 Pedobacter hepa...
YP_585932     92 AVHVGFVGSavlTPLGERIRAFGAIHPdVDVVLHElnsfeQIDALQARhIDIGIIHprvipngIASHSLHGeHFICLLPA 171 Ralstonia metal...
YP_003092687  99 QLRIGFVASamqSVLPGLLKNFHKECPnIKFQLDElnnreQLMALKNEeLDLGFMRsnhvdagYDIRSVYKeTFSLVLPQ 178 Pedobacter hepa...
Feature 1                              ##      #                                                 
YP_299625    172 DHALaaqaevalvdLRAEPFVLFSrkasPDYYSRIFDMCaaqGFYPQIRHEVRHWlSVVSLVSQGmGVAVVPAAlarsgm 251 Ralstonia eutro...
NP_887585    176 RHPArhrrrqkladFRAEPFVLFSrtfsPSYYDQVVARClaaGFHPDIKHQVRHWlTVVACVSKGmGITLVPRAlsradl 255 Bordetella bron...
NP_252284    172 GHRLagqarldlaeLRDEDFILFPrhvsPHYHDLIIARCvdaGFSPRIRHEARLWqTVAAMVGLGmGVALIPETlclawr 251 Pseudomonas aer...
NP_885770    174 THRLagqrslrladLAGEDFVFFAqaasPSYYETVLSLCvaaGFHPAVRHEVRHWlSVAALVASGlGVSIVPAClaragl 253 Bordetella para...
YP_968561    172 GHALagtapvdlhaLAGETFVMFArdvaPANHDNVIALFhraGIHPHTRHAARQWlTVVALVAMRmGVALVPASmaqaav 251 Acidovorax aven...
EAR16048     170 DHPFrgkslgsireFAGESFILFTpeysPDYYRTVLSICedaGFHPQVSHKSVHAhTIFKLVAAGlGVAIVPTSlqhgfq 249 Robiginitalea b...
NP_887532    172 SHPLaarqrirlqaLKDESFVLFPrhfsPEYHDQIIALCmdaGFTPHIRYEVRANaTVVALVAAGfGVAIVPRSvsrvai 251 Bordetella bron...
YP_003091611 176 QHPInefnfkgiaeFSNEPFIFFSsedsPFYHDLITSICedhGFRPKVFHRSVNAlTIFKLIEEGmGLAIVPTSlqygyn 255 Pedobacter hepa...
YP_585932    172 DHPLardrtidvreLRHDDFVLFPrhfsPEFHDQIVALCasvGFTPNIRHQVRHMlTIATLVAKRfGVSIVPRSvdvvtl 251 Ralstonia metal...
YP_003092687 179 NHPInaetfinigqFREEPFILFPndqsQLYYQQIINLCadqGFAPKIAHRSIHApTIFKLVEYGmGVSVIPTSlahten 258 Pedobacter hepa...
Feature 1                                              
YP_299625    252 aGAAFRPLAdatvPSEVYCAWKAapd-hpaRDHFVAMV 288 Ralstonia eutropha JMP134
NP_887585    256 pGVRFSAIEdstvESIVHGAWLKgdgdsaiVQAWHRVV 293 Bordetella bronchiseptica RB50
NP_252284    252 nEVRYLEIEpagaRSEIHAILPAsep-sraAQAFLATL 288 Pseudomonas aeruginosa PAO1
NP_885770    254 aGTCYVAFEhq-aRSVCQIAWPSlaptslqATALQAAL 290 Bordetella parapertussis 12822
YP_968561    252 qGVRFVPIAhlehPTVGVLAWHEegt-npaLQAFLDVA 288 Acidovorax avenae subsp. citrulli AAC00-1
EAR16048     250 lKVRFLELSgirqRAVLTAVWNRahh-snaLQHCIEHL 286 Robiginitalea biformata HTCC2501
NP_887532    252 dGIRFRPLAkagvESQLLGVWRDdgh-dslIQPLLAAM 288 Bordetella bronchiseptica RB50
YP_003091611 256 lNVRFIELKnipqRTELYVAWKAsnr-npaLKNVIKLL 292 Pedobacter heparinus DSM 2366
YP_585932    252 pNLACRPLGkqatPSELVGIWRDdeq-gsaVLSMLHAL 288 Ralstonia metallidurans CH34
YP_003092687 259 kEIKFIELKkitqRTELYAVWKKksq-npaLPHLLEML 295 Pedobacter heparinus DSM 2366

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