Conserved Protein Domain Family
PBP2_LTTR_aromatics_like_1

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cd08447: PBP2_LTTR_aromatics_like_1 
The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold.
This CD represents the substrate binding domain of an uncharacterized LysR-type regulator similar to CbnR which is involved in the regulation of chlorocatechol breakdown. The transcription of the genes encoding enzymes involved in such degradation is regulated and expression of these enzymes is enhanced by inducers, which are either an intermediate in the metabolic pathway or compounds to be degraded. This substrate-binding domain shows significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.
Statistics
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PSSM-Id: 176138
View PSSM: cd08447
Aligned: 17 rows
Threshold Bit Score: 263.738
Threshold Setting Gi: 126347751
Created: 23-Sep-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putativeputative
Feature 1:putative substrate binding pocket [chemical binding site]
Evidence:
  • Comment:based on sequeuce similarity to CatM from Acinetobacter baylyi ADP1

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1              #                                                #                        
NP_772510     93 SLKIGFTAaAAYGFLPELVAACRAKLPeVDFSLKEmvsgdQFEALSSGqIDAGLLRPpia----rpeVASRRVVAePLLA 168 Bradyrhizobium ...
NP_792707     93 SVTISFVGsAVYEFLPRVIAEARLKQPqVKISLTEmntyqQHEALRARrIDLGIARAplf----qpgYESACLVRePFVL 168 Pseudomonas syr...
YP_298833     94 KVRVGFTAvAGYELVPNLIARAMQELPeIEVTLHEmvtvaQIEALQAGtIDLGFLRPlpdv---dpeLQWRPAVSePLLL 170 Ralstonia eutro...
YP_001102621  93 IVRIGFTAtSAYGVLGGLLGTARDRLPhVDVVLRElvtrdQVEQLSSGaLDLGLARPtaa----gpgIQSRRIRSePLLA 168 Saccharopolyspo...
YP_001757789  93 VLRLSFTAaSAYRTLPQVVAHVRRTLPeVDLVLEEmvsdeQILALGENrTDLAILRPapvlqdpksaIATAPLAReRLLL 172 Methylobacteriu...
YP_703751     93 TVVVGFTGaSAHAVLPRLLEAARDRLPdVKVVLREmvtsvQIESLISGeLDLGLIRPilt----rpgIDTRPIHHeRLVA 168 Rhodococcus sp....
YP_003060876  93 NLAISFTAaSGYSYLPHLIDVCCSKLPsTQLILREmitsdQIQALESGqVDIGLLRGrfn----lkgYEKRRILReKLIA 168 Hirschia baltic...
YP_119717     93 VVRLGFTGaSVHSGLPRVLATARAALPeVDLELRElvtmdQVEALSEGsLDLGMVRPpit----rpdLTTRPFLReGLVV 168 Nocardia farcin...
YP_002486440  93 VLRVGFTAaSGFSILGPLLGELAGIIPdVDIDLQElvtgeQLSGLLTGeLDLGLARPpfd----setFDSHLLYReSMVV 168 Arthrobacter ch...
YP_002486128  93 TITVGYTAiAGQSALPMMLRKAAEGMPgVSFVLRElvstdQMDGLVKGsVDIGLLRPiva----rpgVVFRPLMQdRLVV 168 Arthrobacter ch...
Feature 1                                        ##      #                                       
NP_772510    169 AIPKKHPLasads------itikdFDDQPFVMYSpyesRYFHDLLVALFtradvlPRYVQHLSQihSILAMVRAGlGLAI 242 Bradyrhizobium ...
NP_792707    169 AVPGNHPLavadt------vgvadLDGVPFLMYShsayPPFNELLTGMFrsarvaPEYVQWLGSslTILALVNAGmGLAL 242 Pseudomonas syr...
YP_298833    171 AMHATHALaarer------iaaedLAGQTFIQYSategKYFHDLIGSVLagagrpPRVVQQMSQthSVLALVRAGlGLAL 244 Ralstonia eutro...
YP_001102621 169 AVPQEHPLargegp-----lelarLDGADVVTYSptdaTYFYDLLISVFraagvrPHYVQHVSQvhTVLALVQVGlGIAL 243 Saccharopolyspo...
YP_001757789 173 AVPRGHRLaaara------ptlrdLDGEAFVTWSprggRYFIDLLDRLFeaggvqPRIVQRVNQvhAMLALVGAGiGVAL 246 Methylobacteriu...
YP_703751    169 ALPAGHPLadaeq------lavedFDDQPVVMYSpvdaRYFHELLISTFtivgasPRYVQYVTQvhTMLVLVRSGlGMAL 242 Rhodococcus sp....
YP_003060876 169 AIPASDPKasket------ltlqdFHASNFIMYTpqraGYFHDMLNKHFeranvePIFTQYMSQihTMLSLVHANlGAAI 242 Hirschia baltic...
YP_119717    169 ALPAEHRLagsdt------vdvraLHGEQLVMHApveaRYFHELVTAVLhragvvPVVTQYMTTvhSILALVDLGwGAAL 242 Nocardia farcin...
YP_002486440 169 AVPAGHPLtllard-----itaedFKDEPLIMHSptqaRYFYDLVVRMLpi--rhANVVHTVSQilTMVSLVAAGrGLAF 241 Arthrobacter ch...
YP_002486128 169 AVPEGSPVlgntripdgqplplgsLDRRPLLMYStkeaRYFHDLVLRLFasagahANITQYASQvpALLAFVQAGlGVTL 248 Arthrobacter ch...
Feature 1                                                            
NP_772510    243 VPAAaaslkisDVRLRPLKlrt----rvPVELFMVWRRddeNPLLSALVKIA 290 Bradyrhizobium japonicum USDA 110
NP_792707    243 VPRCatnvvfrDVVFRDIDlge----gvQSELHLVWRAdndNPACRMLLEAI 290 Pseudomonas syringae pv. tomato str. DC3000
YP_298833    245 VPASarhlhfpGVVLRPIWrd-----dvRAELRLVWRDanrNPACRVFADFA 291 Ralstonia eutropha JMP134
YP_001102621 244 VPSTaarlrveGVEFREVDlpd----pePVELHLMWRRandNPALHALLDLL 291 Saccharopolyspora erythraea NRRL 2338
YP_001757789 247 VPGSargnsmaDIRLRPIAlpa----atGPELWLAWRSdnaNPCLPSVRAAA 294 Methylobacterium radiotolerans JCM 2831
YP_703751    243 VPESaqtmhpeGVVFRPVSavr----drPVQMNAAWRSdnrNPALRRFMEDV 290 Rhodococcus sp. RHA1
YP_003060876 243 VPEAasvlkfsNVEYRPLElps----hyPVELHIVWKKnndNPCIPSLLKHI 290 Hirschia baltica ATCC 49814
YP_119717    243 VPESaaamrfeQVAFRPLTgi-----aaHAELALVWRQgneNPALAKLLDEL 289 Nocardia farcinica IFM 10152
YP_002486440 242 VPHSatllgikDVEFLPLEagr----geEVELHALWNRritNPALARLLRDL 289 Arthrobacter chlorophenolicus A6
YP_002486128 249 VPASamafappGVEFHEIDgrhgmqelnRVDLELAWNEetaNPAVLRLLDLI 300 Arthrobacter chlorophenolicus A6

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