Conserved Protein Domain Family
PBP2_MleR

?
cd08437: PBP2_MleR 
The substrate binding domain of LysR-type transcriptional regulator MleR which required for malolactic fermentation, contains type 2 periplasmic binidning fold.
MleR, a transcription activator of malolactic fermentation system, is found in gram-positive bacteria and belongs to the lysR family of bacterial transcriptional regulators. The mleR gene is required for the expression and induction of malolactic fermentation. This substrate binding domain has significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.
Statistics
?
PSSM-Id: 176128
View PSSM: cd08437
Aligned: 7 rows
Threshold Bit Score: 253.024
Threshold Setting Gi: 24378653
Created: 22-Oct-2009
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
 
putative
Feature 1:putative dimerization interface [polypeptide binding site]
Evidence:
  • Comment:based on sequence similarity to the known structures of LysR-type transcriptional regulators.
  • Comment:Most members of the LysR family of transcriptional regulators are tetrameric, while CrgA assembles into octameric rings

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                       ## ##  #   #  #######                                            
CAR89557      91 KIRFGlppiiggYLFPKIAPDLINTGLm-PQLETIEagsaallDQIKAGklDFAVlgasgplvesdLHVVQINAaPFVII 169 Lactobacillus r...
ZP_05745348   91 RIRFGlppiignYYFPPLTPTLMRAKLm-SRLDTYEhgskellRMLKQGqlDIALlgsltalrqdrLHTQEFARyPFKVI 169 Lactobacillus a...
ZP_05668275   91 KLRFGlppiignEYFPKLSGYFIKHELm-NQIEITDggsrdlyGMIRQGriDLAVlgstqpivdqyLETELLLDkRFMIV 169 Enterococcus fa...
CAI54741      91 ELRFGlppiigtYYFSKLAQKLVKAGSi-QHFATVDggstellASLEAGrlDAALlgsatplendaLTAEIIEQhHFKIV 169 Lactobacillus s...
NP_348215     91 KIKLGvppiigaYFFPPFMKSLIKNNLa-EEIQLVEtgsaamkNLIISGkvDMALlgslspiensaVNSIILKKdAFMLC 169 Clostridium ace...
YP_001310936  92 KLSVGfslgvldALSTDLISDFKKTYPq-IQLDIYEgpdyyceEAVLKGdlDIAFtigpi--nkskFHSKVVKTqHPCVL 168 Clostridium bei...
NP_720608     90 HYSTLgcppiiiNYLLSLLKETNQDLAflKRIRSIRggsvellEQLLQGdlDLSLigtiepfyhdeLVIKKILHrKLYLI 169 Streptococcus m...
Feature 1                                                          ######     ## ##              
CAR89557     170 TRkddplaanks-vrfatlakrQFITLsegfvhtrafawfeqrhtfspniVYRTGDvplLKRLVRQnvgIGFLTriai-- 246 Lactobacillus r...
ZP_05745348  170 VGknhplakqrq-vrfadlkdeNFIVPgseffheqafkqmchnahfrprvLFRTPDihvIKAMVAEnlgISFLTqlai-- 246 Lactobacillus a...
ZP_05668275  170 VPpthplaqqka-vsfkdisdeQFVLLnehyvhpaaftklskqthtqpkvVYQSNDltiLKSMIREnvgIGFLTeiav-- 246 Enterococcus fa...
CAI54741     170 VSpksslanakq-vafrdlaneNFIMLaegfvhpvifdtlstmnqmnpdiIYRTNDvsiLKSMVHEnvgIGFLTetai-- 246 Lactobacillus s...
NP_348215    170 VSkdhplssasn-lnikslskeKFIVLgdsylhnkvfndicsknnispdsVYYTNEiqtAKSLIASglgIGIMInmav-- 246 Clostridium ace...
YP_001310936 169 INeknplskksk-infddlkdeRFIITnqnfkiyhnfiskcrqanfqpniVFSTTEihiVHKLSRLnkgLGISIdfvvid 247 Clostridium bei...
NP_720608    170 VSkdhllakrkkaiafadvlkeNFILLdehnihlkafdylnqthqnqaqiFFKSDDvtlIKQMVSHnmgVSLLTdislt- 248 Streptococcus m...
Feature 1                                                  
CAR89557     247 npddRLATLaiddahqpAFTISIVHRKdrvltpaMKRFESIL 288 Lactobacillus rhamnosus Lc 705
ZP_05745348  247 tptdDLAALsitddeqpTFRLSLATREtavlsadQQKLWQLL 288 Lactobacillus antri DSM 16041
ZP_05668275  247 hpedHLVCLplsdevqpRFLISLAKRTqqlvtplQEQVVQVI 288 Enterococcus faecium 1,141,733
CAI54741     247 tpadDLITLdlldqpqpTFYISLASRKtqlfsatQQALLGTL 288 Lactobacillus sakei subsp. sakei 23K
NP_348215    247 knmdTIKAIpll--epiIFYISIVIKKdhymtlhEKKIKSIL 286 Clostridium acetobutylicum ATCC 824
YP_001310936 248 inypNVRAIpfad-etfVWEINFIHRKdyflsgaSKMLLDYV 288 Clostridium beijerinckii NCIMB 8052
NP_720608    249 kqdhHLVKIpfkennklGFYVNYAYLKsstltpdIRHLVDLL 290 Streptococcus mutans UA159

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap