Conserved Protein Domain Family
C2B_Synaptotagmin-17

?
cd08410: C2B_Synaptotagmin-17 
C2 domain second repeat present in Synaptotagmin 17
Synaptotagmin is a membrane-trafficking protein characterized by a N-terminal transmembrane region, a linker, and 2 C-terminal C2 domains. Synaptotagmin 17 is located in the brain, kidney, and prostate and is thought to be a peripheral membrane protein. Previously all synaptotagmins were thought to be calcium sensors in the regulation of neurotransmitter release and hormone secretion, but it has been shown that not all of them bind calcium. Of the 17 identified synaptotagmins only 8 bind calcium (1-3, 5-7, 9, 10). The function of the two C2 domains that bind calcium are: regulating the fusion step of synaptic vesicle exocytosis (C2A) and binding to phosphatidyl-inositol-3,4,5-triphosphate (PIP3) in the absence of calcium ions and to phosphatidylinositol bisphosphate (PIP2) in their presence (C2B). C2B also regulates also the recycling step of synaptic vesicles. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. This cd contains the second C2 repeat, C2B, and has a type-I topology.
Statistics
?
PSSM-Id: 176055
View PSSM: cd08410
Aligned: 5 rows
Threshold Bit Score: 229.006
Threshold Setting Gi: 72136827
Created: 22-Sep-2009
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
NP_001096478 323 GELLLSLNYLPsaGRLNVDIIRAKQLLQTDmsqGSDPFVKIQLVHglkLAKTKKTSCMRGtIDPFYNESFSFKVPqeele 402 western clawed ...
XP_787981    336 GEILLSLNYLPsaGRLNVDVIKAKQLLQTDivgGSDPFVKLQMISgqkVIKTKKTSTKKNtLDPVFNETFSFHVTpssls 415 purple urchin
AAF37825     323 GELLLSLNYLPsaGRLNVDVIRAKQLLQTDvsqGSDPFVKIQLVHglkLVKTKKTSFLRGtIDPFYNESFSFKVPqeele 402 human
XP_414910    585 GELLLSLNYLPsaGRLNVDIIRAKQLLQTDmsqGSDPFVKIQLVHglkLTKTKKTSCMRGtIDPFYNESFSFKVPqeele 664 chicken
XP_001922508 472 GELLLSLNYLPsaGRLNVDIIRAKQLLQTDmcqGSDPFVKVQLVTglkLMKSKKTSCMRGtIDPCYNESFSFRVPqedlc 551 zebrafish
NP_001096478 403 nvSLVFTVYGHNMKTSNDFIGRIVIGQyasgspESNHWRRMLNSnrtaVEQWHSL 457 western clawed frog
XP_787981    416 dvSLLVSIWDYNTKSRDYFTGQIIMGKfasghsEVTHWQRMRNSqrtpVAQWHTL 470 purple urchin
AAF37825     403 naSLVFTVFGHNMKSSNDFIGRIVIGQyssgpsETNHWRRMLNThrtaVEQWHSL 457 human
XP_414910    665 naSLVFTVYGHNVKSSNDFIGRIVIGQystgapESNHWRRMLNAhrtaVEQWHSL 719 chicken
XP_001922508 552 evSLVLTVYGHNVKSSNDFVGRIVIGQfssgpqETTHWRRLLSSqrtpVEQWHSL 606 zebrafish
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap