Conserved Protein Domain Family
C2B_Synaptotagmin-12

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cd08406: C2B_Synaptotagmin-12 
C2 domain second repeat present in Synaptotagmin 12
Synaptotagmin is a membrane-trafficking protein characterized by a N-terminal transmembrane region, a linker, and 2 C-terminal C2 domains. Synaptotagmin 12, a member of class 6 synaptotagmins, is located in the brain. It functions are unknown. It, like synaptotagmins 8 and 13, do not have any consensus Ca2+ binding sites. Previously all synaptotagmins were thought to be calcium sensors in the regulation of neurotransmitter release and hormone secretion, but it has been shown that not all of them bind calcium. Of the 17 identified synaptotagmins only 8 bind calcium (1-3, 5-7, 9, 10). The function of the two C2 domains that bind calcium are: regulating the fusion step of synaptic vesicle exocytosis (C2A) and binding to phosphatidyl-inositol-3,4,5-triphosphate (PIP3) in the absence of calcium ions and to phosphatidylinositol bisphosphate (PIP2) in their presence (C2B). C2B also regulates also the recycling step of synaptic vesicles. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. This cd contains the second C2 repeat, C2B, and has a type-I topology.
Statistics
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PSSM-Id: 176051
View PSSM: cd08406
Aligned: 7 rows
Threshold Bit Score: 233.144
Threshold Setting Gi: 212516204
Created: 21-Sep-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002208123 136 FGDILFSISYLPTaERLTVVIVKCRNLVwvd-------ekdDADPFVKVYLLQngkKISKKKTSVKRSERCPIYNEAMIF 208 Florida lancelet
Q8IV01       284 VGEILLSLSYLPTaERLTVVVVKAKNLIwtn-------dktTADPFVKVYLLQdgrKMSKKKTAVKRDDPNPVFNEAMIF 356 human
XP_784931    187 EETSCFSLSYLPTaERLTVVIVKARGLYmdk--------hcLSDPFVKVYLLQngkKISKKKTSMKRSETCPIFNEAMMF 258 purple urchin
NP_001122205 283 VGEILLSLSYLPTaERLTVVIAKAKNLVwtn-------gktTADPFVKVYLLQdgrKISKKKTSIKRDDTNPIFNEAMIF 355 zebrafish
EEB18242     443 WGELMLSLNYLPTaERLTVVVVKARNLVfpr-------qrdSGDPFVKVYLLKqgkKLYKKKTSVKKGEKSPIFNEAMIF 515 human body louse
XP_420930    280 VGEILLSLSYLPTaERLTVVVVKAKNLVwsn-------gkgTADPFVKVYLLQdgrKISKKKTAVKRDDTNPVFNEAMIF 352 chicken
NP_572878    612 WGELMFSLSYLPTaERLTIVVVKARNLKldgeqpapesaetVHSVFVKVYLMDkdrKVLKKRTSLKRKDRSPIFNESMIF 691 fruit fly
XP_002208123 209 NVPanalqtiSLRITVSEHTlEGKTPSIGHVIVGPassglALSHWNQMMTSlrKPVAMWHPLR 271 Florida lancelet
Q8IV01       357 SVPaivlqdlSLRVTVAESSsDGRGDNVGHVIIGPsasgmGTTHWNQMLATlrRPVSMWHAVR 419 human
XP_784931    259 SVPstilekvTLRITVAQFGmGGKTPSVGHVLIGAnakgsSLSHWNQMLISlrKPVAMWHSLR 321 purple urchin
NP_001122205 356 SVPaivlqdlSLRVTVAESTeDGRGENVGHVIIGPeasgmGITHWNQMLATlrKPVSMWHPLR 418 zebrafish
EEB18242     516 NVSptslqnlQLRLTVAENIgEPKAYPLGHVILGSqasgkALSHWIQMLSMlrKPTAMWHPLK 578 human body louse
XP_420930    353 SVPaivlqdlSLRVTVAESGeDGRADNTGHVLIGPaasgmGITHWNQMLATlrKPVSMWHPLR 415 chicken
NP_572878    692 SVPppsltttQLRVTVFGVT-TSGVTPLGHIVAGScavgkGLRHWHQMLSSlrKPVAMWHVLR 753 fruit fly
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