Conserved Protein Domain Family
C2_Ras_p21A1

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cd08400: C2_Ras_p21A1 
C2 domain present in RAS p21 protein activator 1 (RasA1)
RasA1 is a GAP1 (GTPase activating protein 1), a Ras-specific GAP member, which suppresses Ras function by enhancing the GTPase activity of Ras proteins resulting in the inactive GDP-bound form of Ras. In this way it can control cellular proliferation and differentiation. RasA1 contains a C2 domain, a Ras-GAP domain, a pleckstrin homology (PH)-like domain, a SH3 domain, and 2 SH2 domains. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. Members here have a type-I topology.
Statistics
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PSSM-Id: 176045
View PSSM: cd08400
Aligned: 11 rows
Threshold Bit Score: 216.465
Threshold Setting Gi: 115928312
Created: 3-Jun-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
BAD92343     624 RQVSSLVLHIEEAHKLPvkHFTNPYCNIYLNSVQVAKTHAREGQNPVWSEEFVFDDlppdINRFEITLSNKTKKskDPDI 703  human
NP_001107303 490 RQVSSLNLHVEEAHKLPmkHFTSPYCNIQLNSVQVAKTHAREGQNPVWSEEFFFDDlspdINRFEIILSNKTKKskDPDI 569  western clawed...
CAM15254     496 RQVSSLVLYVEEAHKLPikHFTNPYCIISLNSVQVARTHPREGQNPVFTEEFIFDDlscdINRFEISLSNKSKKskESDI 575  zebrafish
XP_424907    524 RQVSSLILHVEEAHTLPvkHFTNPYCNIYLNSVQVAKTHIREGQNPVWSEEFVFDDlssdINRFEISLSNKTKKskDPDI 603  chicken
AAL39991     305 RELRCLNLHVLEAHRLPfkLVPHPYCSISLNQVKVGKTRVKIAPEPVWEEEFVLDDvppdVVSLTITLISRGKRgkDSEV 384  fruit fly
XP_001628253 233 KQLRSLELNVIEAHKLPlnKVSHPYCMVSLNEVKTCRTKTFEGQTPLWNEEFKFNDlpsdVSSFTLSLYNKSWRtkDVLI 312  starlet sea an...
XP_002127238 475 RQVRSVQVTIEAAHKLAsrTTCRPYCTLSLNNVHVGRTKVKEDLKPVWSEEFLFDDippdVDSFTVGVHNAARRskHSSI 554  Ciona intestin...
XP_002407986 478 TQVRSLSLTLLEAHRLPvrLAPHPFCIISLNQVKVCRTQVKCPPDPIWEEDFLLEDlpsdVTSFTITLYTKGKRskDMEM 557  black-legged tick
XP_002426247 425 REIRCLQINVLSAHRLPhkLVPNPFCVISLNEVKVAKTKVMTGPDPTWDEEFILDDippdILSFTVSVHNKGKRskNSEV 504  human body louse
XP_781859    488 KQLKSLRLRILEAHNISskQIPHAYCVVSLNEVKVGRTPVQQAPNPVWDEEFMFDDfrdeSDSFTIEICNGAKRakPTPV 567  purple urchin
XP_002592307 409 KQLRSLSVNVLDARNLPvkHLPHPYCMLSLHDVHAARTQMREGPNPLWSEEFVFEDlpreVESFTLLLCSRARRskDAVV 488  Florida lancelet
BAD92343     704 LFMRCQLSRLQKGHATDEWFLLSship-----lkgiEPGSLRVRARYSMEK 749  human
NP_001107303 570 LFMRCQLSRLQKGQTTDEWFQLSship-----lkgiEPGSLRVRARYSMEK 615  western clawed frog
CAM15254     576 LFMRCQLSKLQRGQMIDEWFPLSsyvp-----lkgiEPGSLRVRVRYSMEK 621  zebrafish
XP_424907    604 LFMRCQLSRLQKGHATDEWFQLSshvp-----lkgiEPGSLRVRARYSMEK 649  chicken
AAL39991     385 AELTIDLSSLKNGQETEGWYQLTgmt-------pmgEWGSLRLRMRYLDDL 428  fruit fly
XP_001628253 313 GHVLVPLNKLPKGQTVDDWYPLAaash------gkaEVGNVRIRVKFTHEI 357  starlet sea anemone
XP_002127238 555 GEVVVHFSKLSAGKVIDEWHNLTpistgsvsatpapSCGSVRIRARYSNEL 605  Ciona intestinalis
XP_002407986 558 AEVTVELDSLVNCEEMEEWFSLGgltp-----pireDWGSLRMRIRYVHEV 603  black-legged tick
XP_002426247 505 SEITKELHSLKNGEEKEDWHTLSgit-------pigEWGMIKLKTKYVHDL 548  human body louse
XP_781859    568 CRTSVLLDRLTNGSVSDEWYPLIsaanq----sksvEMGSVRARAQFISET 614  purple urchin
XP_002592307 489 ASVYVPLSKLPNGQYVDEWYPVIpesp------ykgDMGSIRIRAHYRSQL 533  Florida lancelet
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