3DBS,3CST,1E8X,3ENE,1E8Y,1HE8,1E7U


Conserved Protein Domain Family
C2_PI3K_class_I_gamma

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cd08399: C2_PI3K_class_I_gamma 
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C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)
PI3Ks (AKA phosphatidylinositol (PtdIns) 3-kinases) regulate cell processes such as cell growth, differentiation, proliferation, and motility. PI3Ks work on phosphorylation of phosphatidylinositol, phosphatidylinositide (4)P (PtdIns (4)P),2 or PtdIns(4,5)P2. Specifically they phosphorylate the D3 hydroxyl group of phosphoinositol lipids on the inositol ring. There are 3 classes of PI3Ks based on structure, regulation, and specificity. All classes contain a C2 domain, a PIK domain, and a kinase catalytic domain. The members here are class I, gamma isoform PI3Ks and contain both a Ras-binding domain and a p85-binding domain. Class II PI3Ks contain both of these as well as a PX domain, and a C-terminal C2 domain containing a nuclear localization signal. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. Members have a type-I topology.
Statistics
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PSSM-Id: 176044
View PSSM: cd08399
Aligned: 11 rows
Threshold Bit Score: 274.096
Threshold Setting Gi: 198429419
Created: 27-Jan-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3DBS_A        208 FT----VSLWDCDRKFRVKIRGIDIpvlp---rntdLTVFVEANIQHGqqvlCQRRTSPKPFt--eEVLWNVWLEFSiki 278  human
XP_415951     350 FT----ISLWDCNRKFRVKIIGIDIpvlp---rntdLTVFVEANIQHGqqllSQRRTSSKPFt--eEVLWNIWLEFDiki 420  chicken
NP_001121428  350 FT----ISLWDCNRKFRVKIIGIDIpvlp---knteLIAFVEANIQHGqqvlSQRRTTCKPFt--eEVLWNSWLEFDiki 420  western clawe...
3CST_A        208 FT----VSLWDCDRKFRVKIRGIDIpvlp---rntdLTVFVEANIQHGqqvlCQRRTSPKPFt--eEVLWNVWLEFSiki 278  human
1E8X_A        209 FT----VSLWDCDRKFRVKIRGIDIpvlp---rtadLTVFVEANIQYGqqvlCQRRTSPKPFt--eEVLWNVWLEFSiki 279  pig
3ENE_A        207 FT----VSLWDCDRKFRVKIRGIDIpvlp---rntdLTVFVEANIQHGqqvlCQRRTSPKPFt--eEVLWNVWLEFSiki 277  human
1E8Y_A        208 FT----VSLWDCDRKFRVKIRGIDIpvlp---rntdLTVFVEANIQHGqqvlCQRRTSPKPFt--eEVLWNVWLEFSiki 278  human
1HE8_A        207 FT----VSLWDCDRKFRVKIRGIDIpvlp---rntdLTVFVEANIQHGqqvlCQRRTSPKPFt--eEVLWNVWLEFSiki 277  human
1E7U_A        209 FT----VSLWDCDRKFRVKIRGIDIpvlp---rtadLTVFVEANIQYGqqvlCQRRTSPKPFt--eEVLWNVWLEFSiki 279  pig
NP_998471     351 FT----ISLWDCNRKFRVKILGIDIpvlp---rnseLIVFVEASIFHGqqllAQERTSSKPFt--eEVIWNTWLEFNiki 421  zebrafish
XP_002122754  384 HTeivaFSLWDMTRKFRIKVLGVDYltpenetvgtpDELYVEFSLYSGrq-rLAEPVRTKPVasnaDLRWYTSLEFDill 462  Ciona intesti...
3DBS_A        279 kdlpkgaLLNLQIYCGKapalsskasae---spsseskgkvQLLYYVNLLLIdhrfLLRRGEYVLHMwqisgkgedqgSF 355  human
XP_415951     421 kdlpkgaLLNLQIYCGKaqglstktnlqshespnsdskcktQLLYYVNLLLIdhrfLLRSGEYVLHMwkipgkgeeqgSI 500  chicken
NP_001121428  421 kdlpkgaLLNLQIFCGKaptasnksivqspestasdskcknQLLYYVNLLLIdhrfLLRQGEYVLHMwkipgkgeeqgSI 500  western clawe...
3CST_A        279 kdlpkgaLLNLQIYCGKapalsskasae---spsseskgkvQLLYYVNLLLIdhrfLLRRGEYVLHMwqisgkgedqgSF 355  human
1E8X_A        280 kdlpkgaLLNLQIYCGKapalsgktsae---mpspeskgkaQLLYYVNLLLIdhrfLLRHGEYVLHMwqlsgkgedqgSF 356  pig
3ENE_A        278 kdlpkgaLLNLQIYCGKapalsskasae---spsseskgkvRLLYYVNLLLIdhrfLLRRGEYVLHMwqisgkgedqgSF 354  human
1E8Y_A        279 kdlpkgaLLNLQIYCGKapalsskasae---spsseskgkvRLLYYVNLLLIdhrfLLRRGEYVLHMwqisgkgedqgSF 355  human
1HE8_A        278 kdlpkgaLLNLQIYCGKapalsskasae---spsseskgkvRLLYYVNLLLIdhrfLLRRGEYVLHMwqisgkgedqgSF 354  human
1E7U_A        280 kdlpkgaLLNLQIYCGAkpalsgktsae---mpspeskgkaQLLYYVNLLLIdhrfLLRHGEYVLHMwqlsgkgedqgSF 356  pig
NP_998471     422 kdlpkgaRLSLQVSCGKaqtqtske---------tecknksRLLYYVNLLLVdhrsLLRQGEFILHMwkmpeksednsSV 492  zebrafish
XP_002122754  463 rnvpkeaRLNANIIGIFrtksvkvktgi---ksvssngdqhVILRWANMQLLnhrsVLCTGRHAFKTwpms----yseDV 535  Ciona intesti...
3DBS_A        356 NADKLTSATNPDKen-----smSISILLDNYCHPI 385  human
XP_415951     501 NADKLTSATNPDKen-----smAISIVLDKYCHPI 530  chicken
NP_001121428  501 NADKLTSATNPDKet-----smAISISLDKYCHPV 530  western clawed frog
3CST_A        356 NADKLTSATNPDKen-----smSISILLDNYCHPI 385  human
1E8X_A        357 NADKLTSATNPDKen-----smSISILLDNYCHPI 386  pig
3ENE_A        355 NADKLTSATNPDKen-----smSISILLDNYCHPI 384  human
1E8Y_A        356 NADKLTSATNPDKen-----smSISILLDNYCHPI 385  human
1HE8_A        355 NADKLTSATNPDKen-----smSISILLDNYCHPI 384  human
1E7U_A        357 NADKLTSATNPDKen-----smSISILLDNYCHPI 386  pig
NP_998471     493 NADKLTSATNPDKnn-----smAVAILLDKYCYPV 522  zebrafish
XP_002122754  536 SVETHTGTTAPNDgvestsstaEIHFELDSYMHPV 570  Ciona intestinalis
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