Conserved Protein Domain Family
C2_PI3K_class_III

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cd08397: C2_PI3K_class_III 
C2 domain present in class III phosphatidylinositol 3-kinases (PI3Ks)
PI3Ks (AKA phosphatidylinositol (PtdIns) 3-kinases) regulate cell processes such as cell growth, differentiation, proliferation, and motility. PI3Ks work on phosphorylation of phosphatidylinositol, phosphatidylinositide (4)P (PtdIns (4)P),2 or PtdIns(4,5)P2. Specifically they phosphorylate the D3 hydroxyl group of phosphoinositol lipids on the inositol ring. There are 3 classes of PI3Ks based on structure, regulation, and specificity. All classes contain a C2 domain, a PIK domain, and a kinase catalytic domain. These are the only domains identified in the class III PI3Ks present in this cd. In addition some PI3Ks contain a Ras-binding domain and/or a p85-binding domain. Class II PI3Ks contain both of these as well as a PX domain, and a C-terminal C2 domain containing a nuclear localization signal. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. This cd contains the first C2 repeat, C2A, and has a type-I topology.
Statistics
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PSSM-Id: 176042
View PSSM: cd08397
Aligned: 40 rows
Threshold Bit Score: 123.898
Threshold Setting Gi: 213401279
Created: 12-Oct-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002186929   26 LEGKREqksyKALLEDPMLKfsglyqetcSDLYVTCQVFAEgk--plALPIRTSYKAfs-tRWNWNEWLKLPVKypdlpr 102  zebra finch
EDK40259       31 GPKQVRlatsSEKYSEPSVFrklsnvnatSEFYVQVQIYQEnn--piSNPVQTSYQPftanRRLWNQWLQLPIYfnqlsl 108  Pichia guilli...
XP_001382736   40 RDMKDSlaslSEKFEDPAVFntlsriyrfSDLFIKISIFDGknnnlvTIPVQTTYKSfn-nKRVWNQYLKMAINfnqvsi 118  Pichia stipit...
XP_453887      25 LEGSSAllkqSEKYTEPDLSkrasnfipnSDMFVSLQVFDGetgrnlTIPVYTKYVPfk-nSRVWDQWLTLPIKinqldm 103  Kluyveromyces...
CAG90601       45 SKVFDElspsSEKYSNPLVFqklsniyinSDLFVTIQVFSGtsn-piTIPVQTPYQAftnnKREWNRTLKLPINynqlti 123  Debaryomyces ...
NP_986554      25 LHGTKKllqpSQRFTHPELTqrtsnmrlnSDMFVSVQVFDRernralTTPVHTQYVPfk-tGRVWNQWLTLPIYinqldr 103  Ashbya gossyp...
CAR24131       25 LEGVKPlltaSQKLTEPSLSqrasnvapnSDMFVSVQVFDRetlrnlTIPVYTPYVPfk-nARKWDLWLTLPITidqlts 103  Lachancea the...
EEQ38879       44 NTNSHSvassSQKYKDAFVFqklsnisinSDLFLRVQVFDEnhn-alSLPVQTPYKAfsnnKRIWDSSLKLPVNfnqvsy 122  Clavispora lu...
XP_002495847   25 LEGHKPllkhSQKLSQPALSqtasnvfpiSDMLVSAQVFDKerdrnlTIPIVTPYVPfk-sSRKWDQWLNLPINlnqlnt 103  Zygosaccharom...
P22543         25 LEGHKPllkpSQKILNPELMligsnvfpsSDLIVSLQVFDKernrnlTLPIYTPYIPfr-nSRTWDYWLTLPIRikqltf 103  baker's yeast
XP_002186929  103 naQVALTIWDVYgpgkaVPVGGTTVSLFgk-ygMFRQGMHDLKVWpnveadgseptktpgrtsstvsedqMSRLAKLTKS 181  zebra finch
EDK40259      109 saYIVLAIYEICdt-spSLVGVGTLPMFntsecTLNKGTQKVAIRarglpgs------------fegcceLSSSESNLIK 175  Pichia guilli...
XP_001382736  119 dsYLKIEVYEIVnt-kpKLFGVGYLSLFnrkssRLRKGSQKIPIFtdptteni----------eyenipgLTDLEKNLIK 187  Pichia stipit...
XP_453887     104 tsTLLIELWEYNgd-trSIFAKLETQIFnshdySLKRGREVFKFTkdnek---------------ralpmKDQNIALIND 167  Kluyveromyces...
CAG90601      124 dsYLRVVVYEVSnt-rpVIFGIGNISLFnkndsTLRRGSQKVPVRrdfdfskni-------eieygpisgITELEQKLID 195  Debaryomyces ...
NP_986554     104 nsTLQITIWEYDaa-ncIEFATLKTPVFsdadcTLKRGREALHFEygape---------------ssrveGDAIQGLLNK 167  Ashbya gossyp...
CAR24131      104 nsILRIILWEFEgd-neVEFFTIETSLYkedskTLKRGTESFRFQydepn---------------sgaleLDPAKELVNN 167  Lachancea the...
EEQ38879      123 gsYLEFTLLEIVqt-keCVFGMGRLSLFnhansTLRKGSYKIAIGpepgkvd------------yfdsesTTELERSIVR 189  Clavispora lu...
XP_002495847  104 ssWLRIVIWEFEgt-krVPFFILNTPIFnlednTLKRGQESLQFQyddpqs--------------grkleNDPLLDSLNR 168  Zygosaccharom...
P22543        104 ssHLRIILWEYNgs-kqIPFFNLETSIFnlkdcTLKRGFESLKFRydvidh--------------cevvtDNKDQENLNK 168  baker's yeast
XP_002186929  182 HRQGH 186  zebra finch
EDK40259      176 YENGD 180  Pichia guilliermondii ATCC 6260
XP_001382736  188 YEDGE 192  Pichia stipitis CBS 6054
XP_453887     168 YHTGE 172  Kluyveromyces lactis NRRL Y-1140
CAG90601      196 YENGE 200  Debaryomyces hansenii
NP_986554     168 YDQGG 172  Ashbya gossypii ATCC 10895
CAR24131      168 YRKGE 172  Lachancea thermotolerans
EEQ38879      190 HENGD 194  Clavispora lusitaniae ATCC 42720
XP_002495847  169 FYLGE 173  Zygosaccharomyces rouxii CBS 732
P22543        169 YFQGE 173  baker's yeast
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