Conserved Protein Domain Family
C2A_SLP-1_2

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cd08393: C2A_SLP-1_2 
C2 domain first repeat present in Synaptotagmin-like proteins 1 and 2
All Slp members basically share an N-terminal Slp homology domain (SHD) and C-terminal tandem C2 domains (named the C2A domain and the C2B domain) with the SHD and C2 domains being separated by a linker sequence of various length. Slp1/JFC1 and Slp2/exophilin 4 promote granule docking to the plasma membrane. Additionally, their C2A domains are both Ca2+ independent, unlike Slp3 and Slp4/granuphilin which are Ca2+ dependent. It is thought that SHD (except for the Slp4-SHD) functions as a specific Rab27A/B-binding domain. In addition to Slps, rabphilin, Noc2, and Munc13-4 also function as Rab27-binding proteins. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. This cd contains the first C2 repeat, C2A, and has a type-I topology.
Statistics
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PSSM-Id: 176039
View PSSM: cd08393
Aligned: 9 rows
Threshold Bit Score: 221.538
Threshold Setting Gi: 50414723
Created: 14-Dec-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CAG32005     253 RGCVQFSLRYEaaaqELRVHVVRCRQLAEAKRq--RSDPYIKTYLLPDKsnRSKRKTSVRKRsLDPVFNETLKYNVrkaE 330  chicken
CAG08897      50 QGNIIFSINYIqklrEFHIFVAKCQDLATADPkkgRSDPYVKSYLVPDNsnLGKRKTSVKKKtLNPTFNEILRYRVnmeY 129  Tetraodon nigr...
AAH77272     226 RGCVQFSLQYDpskkELNVLIIQCRDLTPAQSk--TSNPYIKCYLLPDKtaQGKRKSKLKKKtLEPFFNETLKYKVewsE 303  African clawed...
AAH82628     577 KGNIQFALDYAdnlqEFQVFVSQCKDLAAADVkkqRSDPYVKAYLLPEKakMGKRKTGVKKKnLNPVYNDVLRYKItknA 656  African clawed...
AAI24817      55 QGSVEFAVMYSpv-gELIIMIEQCQDLAIANPrkqRTDPYVKTYLYPDKsrRSKRKTTIKKRtVNPVFVESLRYKVnreE 133  zebrafish
NP_001122005 242 SGRIQFSLQYDvrteELYVHIIRCQDLASARKn--RSDPYVKVYLLPDNtsRSKKKTAVRRKtLNPVYDETMTYKVrrlD 319  zebrafish
Q8IYJ3       267 RGSVHFALHYEpgaaELRVHVIQCQGLAAARRr--RSDPYVKSYLLPDK--QSKRKTAVKKRnLNPVFNETLRYSVpqaE 342  human
XP_420325    629 QGTVEFALDYDeknrEFQVHVSQCKDLAVVDEkkdRTDPYVKTYLLPDKarMGKRKTSVKKRtVNPVYNEVLRYKIekmV 708  chicken
Q99N50       645 KGSVQFALDYVeslkELHVFVAQCKDLAAADVkkqRSDPYVKTYLLPDKgkMGKKKTLVVKKtLNPVYNEILRYKIerqF 724  house mouse
CAG32005     331 LRGRTLNLSVWHHDALGRNLFLGEVEVPLGEWDWa---nTRPEWFNLQ 375  chicken
CAG08897     130 LRTQTLILSVWHHDTFAKNSFLGEVDLDLSKWDFd---hTRMNYFPLK 174  Tetraodon nigroviridis
AAH77272     304 LQSRVLNLSVWHRGSLGRNLFLGEVEVDLVSWDWs---kTQPAWYNLQ 348  African clawed frog
AAH82628     657 LLSQTLNISVWHYDVLGRNSFLGEVEVNLGSWDWs---nKQMNWYPLQ 701  African clawed frog
AAI24817     134 LPEKSLNLSVWHNDSRGRNVFLGQVELSFRTWDWg---hEALTWYNLQ 178  zebrafish
NP_001122005 320 LPARVLSMSVWHMERMRRNLFLGELEVRLGQWDWs---qNQPTWQNLQ 364  zebrafish
Q8IYJ3       343 LQGRVLSLSVWHRESLGRNIFLGEVEVPLDTWDWg----SEPTWLPLQ 386  human
XP_420325    709 LLIQKLNLSVWHNDPLGRNSFLGEIELDLASWDWs---nRKLNWYPLK 753  chicken
Q99N50       725 LKTQKLNLSVWHRDTFKRNSFLGEVELDLETWDWdskqnKQLKWYPLK 772  house mouse
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