Conserved Protein Domain Family
C2A_SLP-3

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cd08392: C2A_SLP-3 
C2 domain first repeat present in Synaptotagmin-like protein 3
All Slp members basically share an N-terminal Slp homology domain (SHD) and C-terminal tandem C2 domains (named the C2A domain and the C2B domain) with the SHD and C2 domains being separated by a linker sequence of various length. SHD of Slp (except for the Slp4-SHD) function as a specific Rab27A/B-binding domain. In addition to Slp, rabphilin, Noc2, and Munc13-4 also function as Rab27-binding proteins. Little is known about the expression or localization of Slp3. The C2A domain of Slp3 is Ca2+ dependent. It has been demonstrated that Slp3 promotes dense-core vesicle exocytosis. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. This cd contains the first C2 repeat, C2A, and has a type-I topology.
Statistics
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PSSM-Id: 176038
View PSSM: cd08392
Aligned: 4 rows
Threshold Bit Score: 212.766
Threshold Setting Gi: 125846168
Created: 14-Dec-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002196139 261 TGEIEFALKYNfracILEICIKGCKNLAYGEEkkkKCNPYVKVYLLPDKspWSKRKTAVKKGtVDPEFDETLKYKIehsQ 340 zebra finch
XP_690816     71 TGEIEVVLAYNnrtsCLEITIKACRNLMFRDTk-kKCHPYVNVCLLPKKchNFKMKTAVRKG-KNPVYNETFTCVLsadL 148 zebrafish
CAG09204     284 MGELELSLHYNrdtfCLEVTVGAGRNLSYGDPrkkQCHPYVKLCVLPEK--SSKLKTAVKKHtTNPIFNEVLKYPVerhL 361 Tetraodon nigro...
Q4VX76       307 TGEIEFAIHYCfkthSLEICIKACKNLAYGEEkkkKCNPYVKTYLLPDRssQGKRKTGVQRNtVDPTFQETLKYQVapaQ 386 human
XP_002196139 341 LRSRQLQVSVWHAGALKYRVFLGEVVIPLAAWNFee-dsMQFDWYPLK 387 zebra finch
XP_690816    149 LSSAVLQLSVWHSRGLKRRLFLGETLIRLADMDLedtdsQRSLCCKLN 196 zebrafish
CAG09204     362 LIGKRLQASVWHSRTLKRKTFLGEVLIPLDGWRFddkafQGFNWYPLC 409 Tetraodon nigroviridis
Q4VX76       387 LVTRQLQVSVWHLGTLARRVFLGEVIIPLATWDFedsttQSFRWHPLR 434 human
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