Conserved Protein Domain Family
C2A_C2C_Synaptotagmin_like

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cd08391: C2A_C2C_Synaptotagmin_like 
C2 domain first and third repeat in Synaptotagmin-like proteins
Synaptotagmin is a membrane-trafficking protein characterized by a N-terminal transmembrane region, a linker, and 2 C-terminal C2 domains. Previously all synaptotagmins were thought to be calcium sensors in the regulation of neurotransmitter release and hormone secretion, but it has been shown that not all of them bind calcium. Of the 17 identified synaptotagmins only 8 bind calcium (1-3, 5-7, 9, 10). The function of the two C2 domains that bind calcium are: regulating the fusion step of synaptic vesicle exocytosis (C2A) and binding to phosphatidyl-inositol-3,4,5-triphosphate (PIP3) in the absence of calcium ions and to phosphatidylinositol bisphosphate (PIP2) in their presence (C2B). C2B also regulates also the recycling step of synaptic vesicles. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. This cd contains either the first or third repeat in Synaptotagmin-like proteins with a type-I topology.
Statistics
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PSSM-Id: 176037
View PSSM: cd08391
Aligned: 17 rows
Threshold Bit Score: 154.757
Threshold Setting Gi: 47229535
Created: 15-Sep-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Ca2+ binding
Feature 1:Ca2+ binding site [ion binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                     #                                                # #
AAH78229      302 GVVRVHVLEARDLVAKDkhvmglvkGKSDPYTVLRVGn-kHFKTKTIKETLNPRWNEVYEFVIHEa-PGQELEVELYDED 379  zebrafish
XP_002125044  358 GVIRIHVIEARNLEEKDkkvl-gfgGGSDPYVTVQVGhrqKFKTAVVTHNLNPVWNEVFDVVVPDv-PTTQIQFSLFDDD 435  Ciona intesti...
XP_001638340  286 GVLRVEVIEAKDLIAADmal--lskPTSDPYCIVEVGa-qKYRTKTKKSNCDPVWKETFEAFIDNt-EGQELFCKVYDED 361  starlet sea a...
CAE51055      314 GVVRIHLLEADNLAAKDnyvkgvmaGMSDPYAIVRVGp-qTFKSHHLDNTLSPKWGEVYEVVVHEv-PGQELEVEVFDKD 391  zebrafish
XP_001625031  316 GVLRIEVTEAKDLVAKDiav--fkkGTSDPYAMVKVGa-qTFRTETKKETLNPKWNEVFEVFVDNs-QGQKIKIQLFDED 391  starlet sea a...
AAX26199      295 GVLHINVISGRNLKAGDknv--ighNTSDPYCVVRVGa-rSFTTSVVKETLEPVWNQHFESIVDIc-HGQSVTVEVYDKD 370  Schistosoma j...
CAG06731      890 GLVRIILLEAQSLIAKDnmmggmvkGKSDPYAKISVGe-fTFKSSVIKENLNPVWNEMYEVVLKPesEQVQVKIELFDKD 968  spotted green...
Q5RAG2        647 HVLRIHVLEAQDLIAKDrflgglvkGKSDPYVKLKLAg-rSFRSHVVREDLNPRWNEVFEVIVTSv-PGQELEVEVFDKD 724  Sumatran oran...
CAG07403      742 GVLRIHLVEAQNLIAKDnfmggmvkGKSDPYVKIRVAg-iTYRSHTIKENLNPIWNELYEVILTQl-PGQEIQFELFDKD 819  Tetraodon nig...
XP_001183287  365 GVLRITAVEARNLVRADmgl--lkkGKSDPYLIINVGm-qKFKTKTINNNLNPKWNQTFEALVYEe-HGQTLDVDCWDED 440  purple urchin
Feature 1               #                                                     
AAH78229      380 KD--ADDFLGRFSMDCGDVr----------KDREIDKWYTLedi-----esGQIHFKLQW 422  zebrafish
XP_002125044  436 GAlnKSDNLGMCSIPVKSVf----------KQGIIDEWVQLsdfiigdigqGRCKFFPTL 485  Ciona intestinalis
XP_001638340  362 IAg-KDTEIGEVDVQVASAf----------ENGKTDLWLHLegv-----eeGRIHLGLKW 405  starlet sea anemone
CAE51055      392 PD--HDDFLGRTKLDLGIVk----------KSKIVDEWFNLkdt-----qtGRVHLKLEW 434  zebrafish
XP_001625031  392 RAs-DDEALGSVEADISTVv----------QQGSADLWLPLenv-----asGQINLHCTW 435  starlet sea anemone
AAX26199      371 QGn-KDDYLGCTSIPIESVl----------NKGEVDTWVVS----------GRCKNWFIT 409  Schistosoma japonicum
CAG06731      969 VD--KDDFLGRYQTSLTVQqwytlndvksgRVRLILEWVQTis------hnATLEQVMQM 1020 spotted green pufferfish
Q5RAG2        725 LD--KDDFLGRCKVSLTTVl----------NSGFLDEWLTLedv-----psGRLHLRLER 767  Sumatran orangutan
CAG07403      820 ID--QDDFLGRFKLSLRDIi----------SAQFIDTWYTLndv-----ksGRVHLVLEW 862  Tetraodon nigroviridis
XP_001183287  441 PGs-KDDPLGNLSIDIHYIs----------KMGTFDSWLPLedi-----khGDLHLHLEW 484  purple urchin

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