3RPB,2CM6,2CM5


Conserved Protein Domain Family
C2B_Rabphilin_Doc2

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cd08384: C2B_Rabphilin_Doc2 
Click on image for an interactive view with Cn3D
C2 domain second repeat present in Rabphilin and Double C2 domain
Rabphilin is found neurons and in neuroendrocrine cells, while Doc2 is found not only in the brain but in tissues, including mast cells, chromaffin cells, and osteoblasts. Rabphilin and Doc2s share highly homologous tandem C2 domains, although their N-terminal structures are completely different: rabphilin contains an N-terminal Rab-binding domain (RBD),7 whereas Doc2 contains an N-terminal Munc13-1-interacting domain (MID). C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. This cd contains the second C2 repeat, C2B, and has a type-I topology.
Statistics
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PSSM-Id: 176030
View PSSM: cd08384
Aligned: 14 rows
Threshold Bit Score: 212.208
Threshold Setting Gi: 238660825
Created: 2-Jun-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Ca2+ binding
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:Ca2+ binding site [ion binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                    #     #                                             
3RPB_A         3 KILVSLMYStqqgGLIVGIIRCVHLAAMDangySDPFVKLWLkpdmgkkaKHKTQIKKktlNPEFNEEFFYDikhsdlak 82  Norway rat
2CM6_A        25 KILVSLMYStqqgGLIVGIIRCVHLAAMDangySDPFVKLWLkpdmgkkaKHKTQIKKktlNPEFNEEFFYDikhsdlak 104 Norway rat
XP_790269     97 KLMVGLKYVstrqCLVVSIIRGAGLAAMDsngySDPYVKVYLkpdagkrtKHKTAVKKrtlNPEFNEEFYYEvkhpelak 176 purple urchin
AAH77398     551 KILVSLMYNsqqgGLIVGIVRCVHLAAMDangySDPFVKLWLkpdmgkkaKSKTQIKKktlNPEFNEEFFYDikhsdlak 630 African clawed ...
NP_001122026 288 RILVSLLYNteknTLVVGIIRCAHLAAMDsngySDPFVKIILqpdmgkksKYKTTVKKktlNPEFNEEFSYDvphdqlak 367 zebrafish
XP_415177    538 KILVSLMYStqqgGLIVGIVRCVHLAAMDangySDPFVKLWLkpdmgkkaKHKTQIKKktlNPEFNEEFFYDikhsdlak 617 chicken
NP_572651    499 KMLLSLCYNtkrrALVVNVKQCINLMAMDnngsSDPFVKIQLkpdahknkKHKTSVKWrtlNPIYNEEFYFEasphdlnk 578 fruit fly
XP_001633996 156 RIQLALKYNtqrgMLFVTVMRCSGLASMDangySDPYVKCYLkpdpqkksKRRTNIRKktlNPEFNEEFVYDiahhelak 235 starlet sea ane...
XP_002115717 501 RIEISLKYVtatrTLEVGIIQCIGLKAMDasgySDPYVKCYLrpdkykitKQKTSVKRrtlNPKFNAVFKYKyahselag 580 Trichoplax adha...
XP_397223    595 QIQVSLSYCtrrrALIVTIHRAINLLPMDsngfSDPFVKLCLienvtnnhRQRTTIKWktlNPEWNEEFTFTarltdlmk 674 honey bee
Feature 1                # #     #                                    
3RPB_A        83 kSLDISVWDYDigKSNDYIGGCQLgisakgeRLKHWYECLknkdkkIERWHQL 135 Norway rat
2CM6_A       105 kSLDISVWDYDigKSNDYIGGCQLgisakgeRLKHWYECLknkdkkIERWHQL 157 Norway rat
XP_790269    177 kTLEITVWDKDiaKANDYIGGVQLgitskgeRLRHWFETLkgidkkYERWHTL 229 purple urchin
AAH77398     631 kQLDISVWDYDigKSNDYIGGCQLginakgeRLKHWYECLknkdkkIERWHVL 683 African clawed frog
NP_001122026 368 kTLEISVWDYDlgMSNDFIGGVELginakgdRLKHWFECLkykgkkVEYWHTL 420 zebrafish
XP_415177    618 kSLDISVWDYDigKSNDYIGGCQLgitakgeRLKHWYECLknkdkkIERWHTL 670 chicken
NP_572651    579 eMLILTVWDKDlgKSNDFLGSLQLgaqskgeRLQQWLDCIrlpdhfHEKWHCL 631 fruit fly
XP_001633996 236 kSLEVTVWDYDvgKSNDFIGGVILninaegsALKHWYDMLkgpnqlHTQWHTL 288 starlet sea anemone
XP_002115717 581 kTLDIQVWDRDigRKNDFIGGVYLgkdssgdQLRHWFQTLktpnakFTHFHTL 633 Trichoplax adhaerens
XP_397223    675 lTLYLTIWDKDfgKNNDYLGGLELsrnskgaRLRHWIDVIkfpdhrHQAWHNL 727 honey bee

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