Conserved Protein Domain Family
C2A_RasGAP

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cd08383: C2A_RasGAP 
C2 domain (first repeat) of Ras GTPase activating proteins (GAPs)
RasGAPs suppress Ras function by enhancing the GTPase activity of Ras proteins resulting in the inactive GDP-bound form of Ras. In this way it can control cellular proliferation and differentiation. The proteins here all contain either a single C2 domain or two tandem C2 domains, a Ras-GAP domain, and a pleckstrin homology (PH)-like domain. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. Members here have a type-I topology.
Statistics
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PSSM-Id: 176029
View PSSM: cd08383
Aligned: 23 rows
Threshold Bit Score: 153.574
Threshold Setting Gi: 215494687
Created: 27-Oct-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative Ca2+
Feature 1:putative Ca2+ binding site [ion binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                              #                                                 # #    #
Q28013        13 SVKIKIGEAKNLPtypgpnkmRDCYCTVNLdqeeVFRTKVVEkslCPFYGEDFYCEipr---sfrHLSFYIFDRDvfrrD 89   cattle
BAD92343     628 SLVLHIEEAHKLPvk----hfTNPYCNIYLnsvqVAKTHAREg-qNPVWSEEFVFDdlppdinrfEITLSNKTKKskdpD 702  human
NP_001107303 494 SLNLHVEEAHKLPmk----hfTSPYCNIQLnsvqVAKTHAREg-qNPVWSEEFFFDdlspdinrfEIILSNKTKKskdpD 568  western clawed...
CAM15254     500 SLVLYVEEAHKLPik----hfTNPYCIISLnsvqVARTHPREg-qNPVFTEEFIFDdlscdinrfEISLSNKSKKskesD 574  zebrafish
XP_424907    528 SLILHVEEAHTLPvk----hfTNPYCNIYLnsvqVAKTHIREg-qNPVWSEEFVFDdlssdinrfEISLSNKTKKskdpD 602  chicken
AAL39991     309 CLNLHVLEAHRLPfk----lvPHPYCSISLnqvkVGKTRVKIa-pEPVWEEEFVLDdvppdvvslTITLISRGKRgkdsE 383  fruit fly
XP_001628253 237 SLELNVIEAHKLPln----kvSHPYCMVSLnevkTCRTKTFEg-qTPLWNEEFKFNdlpsdvssfTLSLYNKSWRtkdvL 311  starlet sea an...
XP_002407986 482 SLSLTLLEAHRLPvr----laPHPFCIISLnqvkVCRTQVKCp-pDPIWEEDFLLEdlpsdvtsfTITLYTKGKRskdmE 556  black-legged tick
XP_002426247 429 CLQINVLSAHRLPhk----lvPNPFCVISLnevkVAKTKVMTg-pDPTWDEEFILDdippdilsfTVSVHNKGKRsknsE 503  human body louse
XP_002592307 413 SLSVNVLDARNLPvk----hlPHPYCMLSLhdvhAARTQMREg-pNPLWSEEFVFEdlprevesfTLLLCSRARRskdaV 487  Florida lancelet
Feature 1                                                     
Q28013        90 SIIGKVAIkkedlqkyhnrDTWFQLqhvda-dsevqGKVHLELRL 133  cattle
BAD92343     703 ILFMRCQLsrlqk--ghatDEWFLLsshiplkgiepGSLRVRARY 745  human
NP_001107303 569 ILFMRCQLsrlqk--gqttDEWFQLsshiplkgiepGSLRVRARY 611  western clawed frog
CAM15254     575 ILFMRCQLsklqr--gqmiDEWFPLssyvplkgiepGSLRVRVRY 617  zebrafish
XP_424907    603 ILFMRCQLsrlqk--ghatDEWFQLsshvplkgiepGSLRVRARY 645  chicken
AAL39991     384 VAELTIDLsslkn--gqetEGWYQLtgmtp--mgewGSLRLRMRY 424  fruit fly
XP_001628253 312 IGHVLVPLnklpk--gqtvDDWYPLaaash-gkaevGNVRIRVKF 353  starlet sea anemone
XP_002407986 557 MAEVTVELdslvn--ceemEEWFSLggltppiredwGSLRMRIRY 599  black-legged tick
XP_002426247 504 VSEITKELhslkn--geekEDWHTLsgitp--igewGMIKLKTKY 544  human body louse
XP_002592307 488 VASVYVPLsklpn--gqyvDEWYPVipesp-ykgdmGSIRIRAHY 529  Florida lancelet

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